Synonym
AEAD, CL 232468; CL-232468; CL232468
IUPAC/Chemical Name
9,10-Anthracenedione, 1,4-bis((2-aminoethyl)amino)-5,8-dihydroxy
InChi Key
CLVFWRBVFBUDQU-UHFFFAOYSA-N
InChi Code
InChI=1S/C18H20N4O4/c19-5-7-21-9-1-2-10(22-8-6-20)14-13(9)17(25)15-11(23)3-4-12(24)16(15)18(14)26/h1-4,21-24H,5-8,19-20H2
SMILES Code
O=C1C2=C(C(O)=CC=C2O)C(C3=C(NCCN)C=CC(NCCN)=C13)=O
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>2 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
Preparing Stock Solutions
The following data is based on the
product
molecular weight
356.38
Batch specific molecular weights may vary
from batch to batch
due to the degree of hydration, which will
affect the solvent
volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass |
1 mg |
5 mg |
10 mg |
| 1 mM |
1.15 mL |
5.76 mL |
11.51 mL |
| 5 mM |
0.23 mL |
1.15 mL |
2.3 mL |
| 10 mM |
0.12 mL |
0.58 mL |
1.15 mL |
| 50 mM |
0.02 mL |
0.12 mL |
0.23 mL |
1: House RV, Lauer LD, Thurmond LM, Cornacoff JB, Dean JH. Selective immunosuppression following exposure to a novel anthraquinone, 1,4-bis[(2-aminoethyl)amino]-5,8-dihydroxy-9,10-anthracenedione dihydrochloride (AEAD). Int J Immunopharmacol. 1989;11(1):95-101. PubMed PMID: 2785091.
2: House RV, Dean JH. Target cell specificity of immunosuppression in murine lymphocytes exposed to 1,4-bis[(2-aminoethyl)amino]-5,8-dihydroxy-9,10-anthracenedione dihydrochloride (AEAD). Int J Immunopharmacol. 1989;11(1):85-93. PubMed PMID: 2523363.
3: House RV, Pallardy MJ, Cornacoff JB, Thurmond LM, Dean JH. Suppression of cytolytic function in murine lymphocytes exposed to 1,4-bis[(2-aminoethyl)amino]-5,8-dihydroxy-9,10-anthracenedione dihydrochloride (AEAD): inhibition of proliferation by cytotoxic T-lymphocyte precursors. Int J Immunopharmacol. 1989;11(3):301-8. PubMed PMID: 2472363.
4: House RV, Dean JH. Trypanosoma musculi: characterization of the T-lymphocyte dependency of immunity by selective immunomodulation of the mouse, Mus musculus. Exp Parasitol. 1988 Oct;67(1):104-15. PubMed PMID: 2971560.
5: Levine S, Gherson J. Morphologic effects of mitoxantrone and a related anthracenedione on lymphoid tissues. Int J Immunopharmacol. 1986;8(8):999-1007. PubMed PMID: 3492454.
6: Wang BS, Lumanglas AL, Ruszala-Mallon VM, Wallace RE, Durr FE. Induction of alloreactive immunosuppression by 1,4-bis [( 2-aminoethyl)amino]-5,8-dihydroxy-9,10-anthracenedione dihydrochloride (CL 232,468). Int J Immunopharmacol. 1984;6(5):475-82. PubMed PMID: 6334042.
