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MedKoo Cat#: 562870 | Name: PQ1

Description:

WARNING: This product is for research use only, not for human or veterinary use.

PQ1 is an enhancer of gap junction in SW480 human colorectal cancer cells. It acts by restoring GJIC and increasing connexin expression in breast cancer cell lines while not affecting normal mammary cells.

Chemical Structure

PQ1
PQ1
CAS#1609196-55-5

Theoretical Analysis

MedKoo Cat#: 562870

Name: PQ1

CAS#: 1609196-55-5

Chemical Formula: C21H22F3N3O3

Exact Mass: 421.1613

Molecular Weight: 421.42

Elemental Analysis: C, 59.85; H, 5.26; F, 13.52; N, 9.97; O, 11.39

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
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Related CAS #
No Data
Synonym
PQ1; PQ-1; PQ 1;
IUPAC/Chemical Name
8-(3-Amino-propylamino)-6-methoxy-4-methyl-5-(3-trifluoromethyl-phenoxy)-1H-quinolin-2-one
InChi Key
VWIMRCUBDMDRNW-UHFFFAOYSA-N
InChi Code
InChI=1S/C21H22F3N3O3/c1-12-9-17(28)27-19-15(26-8-4-7-25)11-16(29-2)20(18(12)19)30-14-6-3-5-13(10-14)21(22,23)24/h3,5-6,9-11,26H,4,7-8,25H2,1-2H3,(H,27,28)
SMILES Code
O=C1NC2=C(C(OC3=CC=CC(C(F)(F)F)=C3)=C(OC)C=C2NCCCN)C(C)=C1
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>2 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 421.42 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Hamid MMA, Thriemer K, Elobied ME, Mahgoub NS, Boshara SA, Elsafi HMH, Gumaa SA, Hamid T, Abdelbagi H, Basheir HM, Marfurt J, Chen I, Gosling R, Price RN, Ley B. Low risk of recurrence following artesunate-Sulphadoxine-pyrimethamine plus primaquine for uncomplicated Plasmodium falciparum and Plasmodium vivax infections in the Republic of the Sudan. Malar J. 2018 Mar 16;17(1):117. doi: 10.1186/s12936-018-2266-9. PubMed PMID: 29548285; PubMed Central PMCID: PMC5857106. 2: Chang CJ, Cheng CC, Chen YC, Kao YH, Chen SA, Chen YJ. Gap junction modifiers regulate electrical activities of the sinoatrial node and pulmonary vein: Therapeutic implications in atrial arrhythmogenesis. Int J Cardiol. 2016 Oct 15;221:529-36. doi: 10.1016/j.ijcard.2016.07.027. Epub 2016 Jul 5. PubMed PMID: 27414735. 3: de Oliveira LF, Santos C, Dos Reis Martinez CB. Biomarkers in the freshwater bivalve Corbicula fluminea confined downstream a domestic landfill leachate discharge. Environ Sci Pollut Res Int. 2016 Jul;23(14):13931-42. doi: 10.1007/s11356-016-6567-7. Epub 2016 Apr 4. PubMed PMID: 27040540. 4: Onofri E, Mercuri M, Archer T, Rapp-Ricciardi M, Ricci S. Legal medical consideration of Alzheimer's disease patients' dysgraphia and cognitive dysfunction: a 6 month follow up. Clin Interv Aging. 2016 Mar 7;11:279-84. doi: 10.2147/CIA.S94750. eCollection 2016. PubMed PMID: 27022252; PubMed Central PMCID: PMC4788358. 5: Lin YZ, Xu N, Li XD, Xue XY, Cai H, Wei Y, Zheng QS. [Quinoline derivative PQ1 combined with cisplatin promotes the proliferation and gap junction communication of prostate cancer PC3 cells]. Zhonghua Nan Ke Xue. 2016 Feb;22(2):116-21. Chinese. PubMed PMID: 26939394. 6: Shishido SN, Nguyen TA. Induction of Apoptosis by PQ1, a Gap Junction Enhancer that Upregulates Connexin 43 and Activates the MAPK Signaling Pathway in Mammary Carcinoma Cells. Int J Mol Sci. 2016 Jan 29;17(2). pii: E178. doi: 10.3390/ijms17020178. PubMed PMID: 26840298; PubMed Central PMCID: PMC4783912. 7: Boruziniat A, Khazaei Y, Motaghi S, Moghaddas M. Evaluation of bond strength of orthodontic brackets without enamel etching. J Clin Exp Dent. 2015 Oct 1;7(4):e519-23. doi: 10.4317/jced.52253. eCollection 2015 Oct. PubMed PMID: 26535100; PubMed Central PMCID: PMC4628808. 8: Onofri E, Mercuri M, Donato G, Ricci S. Cognitive fluctuations in connection to dysgraphia: a comparison of Alzheimer's disease with dementia Lewy bodies. Clin Interv Aging. 2015 Mar 26;10:625-33. doi: 10.2147/CIA.S79679. eCollection 2015. PubMed PMID: 25848239; PubMed Central PMCID: PMC4381903. 9: Lin WC, Licht S. Poly(ethylene glycol) as a scaffold for high-affinity open-channel blockers of the mouse nicotinic acetylcholine receptor. PLoS One. 2014 Nov 11;9(11):e112088. doi: 10.1371/journal.pone.0112088. eCollection 2014. PubMed PMID: 25386750; PubMed Central PMCID: PMC4227698. 10: Bigelow K, Nguyen TA. Increase of gap junction activities in SW480 human colorectal cancer cells. BMC Cancer. 2014 Jul 9;14:502. doi: 10.1186/1471-2407-14-502. PubMed PMID: 25008544; PubMed Central PMCID: PMC4226976. 11: Shishido SN, Delahaye A, Beck A, Nguyen TA. The anticancer effect of PQ1 in the MMTV-PyVT mouse model. Int J Cancer. 2014 Mar 15;134(6):1474-83. doi: 10.1002/ijc.28461. Epub 2013 Sep 19. PubMed PMID: 24038078; PubMed Central PMCID: PMC3948329. 12: Garcia-Febrero R, Valera E, Muriano A, Pividori MI, Sanchez-Baeza F, Marco MP. An electrochemical magneto immunosensor (EMIS) for the determination of paraquat residues in potato samples. Anal Bioanal Chem. 2013 Sep;405(24):7841-9. doi: 10.1007/s00216-013-7209-2. Epub 2013 Jul 26. PubMed PMID: 23887278. 13: Ding Y, Nguyen TA. PQ1, a quinoline derivative, induces apoptosis in T47D breast cancer cells through activation of caspase-8 and caspase-9. Apoptosis. 2013 Sep;18(9):1071-82. doi: 10.1007/s10495-013-0855-1. PubMed PMID: 23677255; PubMed Central PMCID: PMC3735622. 14: Mazzoni A, Scaffa P, Carrilho M, Tjäderhane L, Di Lenarda R, Polimeni A, Tezvergil-Mutluay A, Tay FR, Pashley DH, Breschi L. Effects of etch-and-rinse and self-etch adhesives on dentin MMP-2 and MMP-9. J Dent Res. 2013 Jan;92(1):82-6. doi: 10.1177/0022034512467034. Epub 2012 Nov 5. PubMed PMID: 23128110; PubMed Central PMCID: PMC3521453. 15: Ding Y, Nguyen TA. Gap Junction Enhancer Potentiates Cytotoxicity of Cisplatin in Breast Cancer Cells. J Cancer Sci Ther. 2012 Nov 1;4(11):371-378. PubMed PMID: 25045421; PubMed Central PMCID: PMC4101900. 16: Shishido SN, Nguyen TA. Gap junction enhancer increases efficacy of cisplatin to attenuate mammary tumor growth. PLoS One. 2012;7(9):e44963. doi: 10.1371/journal.pone.0044963. Epub 2012 Sep 13. PubMed PMID: 23028705; PubMed Central PMCID: PMC3441663. 17: Ding Y, Prasain K, Nguyen TD, Hua DH, Nguyen TA. The effect of the PQ1 anti-breast cancer agent on normal tissues. Anticancer Drugs. 2012 Oct;23(9):897-905. doi: 10.1097/CAD.0b013e328354ac71. PubMed PMID: 22569107; PubMed Central PMCID: PMC3428498. 18: Jakovljević A, Pešić D, Popović M, Melih I. [Influence of different bonding agents on marginal sealing quality of amalgam restorations]. Srp Arh Celok Lek. 2011 Nov-Dec;139(11-12):722-7. Serbian. PubMed PMID: 22338466. 19: Deliperi S, Bardwell DN, Alleman D. Clinical evaluation of stress-reducing direct composite restorations in structurally compromised molars: a 2-year report. Oper Dent. 2012 Mar-Apr;37(2):109-16. doi: 10.2341/10-299-C. Epub 2012 Feb 7. PubMed PMID: 22313276. 20: Sabatini C, Campillo M, Hoelz S, Davis EL, Munoz CA. Cross-compatibility of methacrylate-based resin composites and etch-and-rinse one-bottle adhesives. Oper Dent. 2012 Jan-Feb;37(1):37-44. doi: 10.2341/11-095-L. Epub 2011 Sep 13. PubMed PMID: 21913863.