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MedKoo Cat#: 562869 | Name: PI3K inhibitor C 96

Description:

WARNING: This product is for research use only, not for human or veterinary use.

PI3K inhibitor C 96 is an inhibitor of phosphatidylinositol 3-kinase (PI3K). It displays potent activity against multiple myeloma in vitro and in vivo.

Chemical Structure

PI3K inhibitor C 96
PI3K inhibitor C 96
CAS#1502813-63-9

Theoretical Analysis

MedKoo Cat#: 562869

Name: PI3K inhibitor C 96

CAS#: 1502813-63-9

Chemical Formula: C11H8N2O3S

Exact Mass: 248.0256

Molecular Weight: 248.25

Elemental Analysis: C, 53.22; H, 3.25; N, 11.28; O, 19.33; S, 12.91

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
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Related CAS #
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Synonym
PI3K inhibitor C 96; PI3K-IN-C96; PI3K IN C96;
IUPAC/Chemical Name
5-[(E)-3-Thiophen-2-ylprop-2-enylidene]-1,3-diazinane-2,4,6-trione
InChi Key
XVDGTYMDHFXORY-HNQUOIGGSA-N
InChi Code
InChI=1S/C11H8N2O3S/c14-9-8(10(15)13-11(16)12-9)5-1-3-7-4-2-6-17-7/h1-6H,(H2,12,13,14,15,16)/b3-1+
SMILES Code
O=C(NC(/C1=C/C=C/C2=CC=CS2)=O)NC1=O
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>2 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 248.25 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
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Sphingosine-1-phosphate receptor 2 mediates endothelial cells dysfunction by PI3K-Akt pathway under high glucose condition. Eur J Pharmacol. 2016 Apr 5;776:19-25. doi: 10.1016/j.ejphar.2016.02.056. Epub 2016 Feb 26. PubMed PMID: 26921757. 8: Jang JY, Kim YG, Nam SJ, Keam B, Kim TM, Jeon YK, Kim CW. Targeting Adenine Nucleotide Translocase-2 (ANT2) to Overcome Resistance to Epidermal Growth Factor Receptor Tyrosine Kinase Inhibitor in Non-Small Cell Lung Cancer. Mol Cancer Ther. 2016 Jun;15(6):1387-96. doi: 10.1158/1535-7163.MCT-15-0089. Epub 2016 Feb 16. PubMed PMID: 26883272. 9: Xie W, Wang H, Liu Q, Li Y, Wang J, Yao S, Wu Q. ResolvinD1 reduces apoptosis and inflammation in primary human alveolar epithelial type 2 cells. Lab Invest. 2016 May;96(5):526-36. doi: 10.1038/labinvest.2016.31. Epub 2016 Feb 15. PubMed PMID: 26878131. 10: Wang L, Yin J, Wang X, Shao M, Duan F, Wu W, Peng P, Jin J, Tang Y, Ruan Y, Sun Y, Gu J. C-Type Lectin-Like Receptor 2 Suppresses AKT Signaling and Invasive Activities of Gastric Cancer Cells by Blocking Expression of Phosphoinositide 3-Kinase Subunits. Gastroenterology. 2016 May;150(5):1183-1195.e16. doi: 10.1053/j.gastro.2016.01.034. Epub 2016 Feb 6. PubMed PMID: 26855187. 11: Costa C, Pereira S, Lima L, Peixoto A, Fernandes E, Neves D, Neves M, Gaiteiro C, Tavares A, Gil da Costa RM, Cruz R, Amaro T, Oliveira PA, Ferreira JA, Santos LL. Abnormal Protein Glycosylation and Activated PI3K/Akt/mTOR Pathway: Role in Bladder Cancer Prognosis and Targeted Therapeutics. PLoS One. 2015 Nov 16;10(11):e0141253. doi: 10.1371/journal.pone.0141253. eCollection 2015. PubMed PMID: 26569621; PubMed Central PMCID: PMC4646664. 12: De Giusti VC, Orlowski A, Ciancio MC, Espejo MS, Gonano LA, Caldiz CI, Vila Petroff MG, Villa-Abrille MC, Aiello EA. Aldosterone stimulates the cardiac sodium/bicarbonate cotransporter via activation of the g protein-coupled receptor gpr30. 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