MedKoo Cat#: 562868 | Name: Cathepsin Inhibitor 1
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Description:

WARNING: This product is for research use only, not for human or veterinary use.

Cathepsin Inhibitor 1 is a pan-inhibitor of Cathepsin (L, L2, S, K, B).

Chemical Structure

Cathepsin Inhibitor 1
Cathepsin Inhibitor 1
CAS#225120-65-0

Theoretical Analysis

MedKoo Cat#: 562868

Name: Cathepsin Inhibitor 1

CAS#: 225120-65-0

Chemical Formula: C20H24ClN5O2

Exact Mass: 401.1619

Molecular Weight: 401.89

Elemental Analysis: C, 59.77; H, 6.02; Cl, 8.82; N, 17.43; O, 7.96

Price and Availability

Size Price Availability Quantity
25mg USD 750.00 2 Weeks
50mg USD 1,350.00 2 Weeks
100mg USD 2,350.00 2 Weeks
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Synonym
Cathepsin Inhibitor 1; Cathepsin-Inhibitor-1; CTS-IN-1; CTS IN 1;
IUPAC/Chemical Name
(S)-3-(tert-butyl)-N-(3-(3-chlorophenyl)-1-((cyanomethyl)amino)-1-oxopropan-2-yl)-1-methyl-1H-pyrazole-5-carboxamide
InChi Key
MZRVIHRERYCHBL-HNNXBMFYSA-N
InChi Code
InChI=1S/C20H24ClN5O2/c1-20(2,3)17-12-16(26(4)25-17)19(28)24-15(18(27)23-9-8-22)11-13-6-5-7-14(21)10-13/h5-7,10,12,15H,9,11H2,1-4H3,(H,23,27)(H,24,28)/t15-/m0/s1
SMILES Code
ClC1=CC=CC(C[C@@H](C(NCC#N)=O)NC(C2=CC(C(C)(C)C)=NN2C)=O)=C1
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>2 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 401.89 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Coers J, Ranft C, Skoda RC. A truncated isoform of c-Mpl with an essential C-terminal peptide targets the full-length receptor for degradation. J Biol Chem. 2004 Aug 27;279(35):36397-404. Epub 2004 Jun 21. PubMed PMID: 15210714. 2: Zhu DM, Uckun FM. Cathepsin inhibition induces apoptotic death in human leukemia and lymphoma cells. Leuk Lymphoma. 2000 Oct;39(3-4):343-54. PubMed PMID: 11342315.