Pamaqueside | CAS#150332-35-7 | Anti-Atherosclerotic

MedKoo Cat#: 596399 | Name: Pamaqueside

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Pamaqueside is an Anti-Atherosclerotic; Hypocholesterolemic.

Chemical Structure

Pamaqueside

CAS#150332-35-7

Theoretical Analysis

MedKoo Cat#: 596399

Name: Pamaqueside

CAS#: 150332-35-7

Chemical Formula: C39H62O14

Exact Mass: 754.4140

Molecular Weight: 754.91

Elemental Analysis: C, 62.05; H, 8.28; O, 29.67

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.

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Related CAS #

No Data

Synonym

Pamaqueside; L 165313; L165313; L-165313; CP-148,623; CP 148623; CP-148623; CP148623;

IUPAC/Chemical Name

(4R,5'R,6aS,6bS,8aS,8bR,9S,10R,11aS,12aS,12bS)-4-(((2R,3R,4R,5S,6S)-3,4-dihydroxy-6-(hydroxymethyl)-5-(((2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-2-yl)oxy)tetrahydro-2H-pyran-2-yl)oxy)-5',6a,8a,9-tetramethylicosahydrospiro[naphtho[2',1':4,5]indeno[2,1-b]furan-10,2'-pyran]-7(1H)-one

InChi Key

VWMZIGBYZQUQOA-FROLXMRGSA-N

InChi Code

InChI=1S/C39H62O14/c1-17-7-10-39(48-16-17)18(2)27-24(53-39)12-22-21-6-5-19-11-20(8-9-37(19,3)28(21)23(42)13-38(22,27)4)49-35-33(47)31(45)34(26(15-41)51-35)52-36-32(46)30(44)29(43)25(14-40)50-36/h17-22,24-36,40-41,43-47H,5-16H2,1-4H3/t17-,18+,19?,20-,21+,22+,24+,25-,26+,27+,28-,29-,30+,31-,32-,33-,34-,35-,36+,37+,38+,39-/m1/s1

SMILES Code

O[C@H]([C@H]([C@@H]([C@H](CO)O1)O[C@H]2[C@@H]([C@H]([C@@H]([C@@H](CO)O2)O)O)O)O)[C@@H]1O[C@@H](CC3CC[C@@]4([H])[C@]5([H])C[C@@]6(O[C@@]7(OC[C@H](C)CC7)[C@@H](C)[C@@]6([C@]5(C8)C)[H])[H])CC[C@]3(C)[C@@]4([H])C8=O

Appearance

Solid powder

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

Soluble in DMSO

Shelf Life

>2 years if stored properly

Drug Formulation

This drug may be formulated in DMSO

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.9001

More Info

Instruction

View handling instruction

Preparing Stock Solutions

The following data is based on the product molecular weight 754.91 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

1: Pamaqueside. CP 148623. Drugs R D. 2002;3(3):175-6. Review. PubMed PMID: 12099162. 2: Dalvie D, O'Donnell J. Metabolism of pamaqueside, a cholesterol absorption inhibitor, in Long-Evans rat: effect of bile duct cannulation on absorption. Xenobiotica. 1999 Oct;29(10):1043-56. PubMed PMID: 10574685. 3: Pamaqueside. CP 148623. Drugs R D. 1999 Jun;1(6):490. PubMed PMID: 10566093. 4: Morehouse LA, Bangerter FW, DeNinno MP, Inskeep PB, McCarthy PA, Pettini JL, Savoy YE, Sugarman ED, Wilkins RW, Wilson TC, Woody HA, Zaccaro LM, Chandler CE. Comparison of synthetic saponin cholesterol absorption inhibitors in rabbits: evidence for a non-stoichiometric, intestinal mechanism of action. J Lipid Res. 1999 Mar;40(3):464-74. PubMed PMID: 10064735. 5: DeNinno MP, McCarthy PA, Duplantier KC, Eller C, Etienne JB, Zawistoski MP, Bangerter FW, Chandler CE, Morehouse LA, Sugarman ED, Wilkins RW, Woody HA, Zaccaro LM. Steroidal glycoside cholesterol absorption inhibitors. J Med Chem. 1997 Aug 1;40(16):2547-54. PubMed PMID: 9258361. 6: Harris WS, Windsor SL, Newton FA, Gelfand RA. Inhibition of cholesterol absorption with CP-148,623 lowers serum cholesterol in humans. Clin Pharmacol Ther. 1997 Mar;61(3):385-9. PubMed PMID: 9084463. 7: McCarthy PA, DeNinno MP, Morehouse LA, Chandler CE, Bangerter FW, Wilson TC, Urban FJ, Walinsky SW, Cosgrove PG, Duplantier K, Etienne JB, Fowler MA, Lambert JF, O'Donnell JP, Pezzullo SL, Watson HA Jr, Wilkins RW, Zaccaro LM, Zawistoski MP. 11-Ketotigogenin cellobioside (pamaqueside): a potent cholesterol absorption inhibitor in the hamster. J Med Chem. 1996 May 10;39(10):1935-7. PubMed PMID: 8642548.