NSC 5761 | CAS#74-31-7 | bioactive chemical

MedKoo Cat#: 596380 | Name: NSC 5761

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Description:

WARNING: This product is for research use only, not for human or veterinary use.

NSC 5761, also known as p-Phenylenediamine, N,N'-diphenyl- is a bioactive chemical that has been used to prevent vitamin E deficiency in lambs.

Chemical Structure

NSC 5761

CAS#74-31-7

Theoretical Analysis

MedKoo Cat#: 596380

Name: NSC 5761

CAS#: 74-31-7

Chemical Formula: C18H16N2

Exact Mass: 260.1313

Molecular Weight: 260.34

Elemental Analysis: C, 83.04; H, 6.19; N, 10.76

Price and Availability

Size	Price	Availability	Quantity
5g	USD 210.00
25g	USD 380.00

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Related CAS #

No Data

Synonym

p-Phenylenediamine, N,N'-diphenyl-; Flexamine G; DPPD; NSC 5761; NSC-5761; NSC 761;

IUPAC/Chemical Name

N1,N4-diphenylbenzene-1,4-diamine

InChi Key

UTGQNNCQYDRXCH-UHFFFAOYSA-N

InChi Code

InChI=1S/C18H16N2/c1-3-7-15(8-4-1)19-17-11-13-18(14-12-17)20-16-9-5-2-6-10-16/h1-14,19-20H

SMILES Code

C1(NC2=CC=CC=C2)=CC=C(NC3=CC=CC=C3)C=C1

Appearance

Solid powder

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

Soluble in DMSO

Shelf Life

>2 years if stored properly

Drug Formulation

This drug may be formulated in DMSO

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.9001

More Info

Product Data

Product Data

Instruction

View handling instruction

Biological target:

NSC 5761, also known as p-Phenylenediamine, N,N'-diphenyl- is a bioactive chemical that has been used to prevent vitamin E deficiency in lambs.

In vitro activity:

TBD

In vivo activity:

TBD

Preparing Stock Solutions

The following data is based on the product molecular weight 260.34 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

Formulation protocol:

TBD

In vitro protocol:

TBD

In vivo protocol:

TBD

1: Ahmad F, Leake DS. Antioxidants inhibit low density lipoprotein oxidation less at lysosomal pH: A possible explanation as to why the clinical trials of antioxidants might have failed. Chem Phys Lipids. 2018 Mar 5;213:13-24. doi: 10.1016/j.chemphyslip.2018.03.001. [Epub ahead of print] PubMed PMID: 29518380. 2: Bogomolova OE, Sergeyev VG. Acid Doping of Phenyl-Capped Aniline Dimer: Intermolecular Polaron Formation Mechanism and Its Applicability to Polyaniline. J Phys Chem A. 2018 Jan 18;122(2):461-469. doi: 10.1021/acs.jpca.7b09851. Epub 2018 Jan 9. PubMed PMID: 29257873. 3: Greene AS, Hajduk SL. Trypanosome Lytic Factor-1 Initiates Oxidation-stimulated Osmotic Lysis of Trypanosoma brucei brucei. J Biol Chem. 2016 Feb 5;291(6):3063-75. doi: 10.1074/jbc.M115.680371. Epub 2015 Dec 8. PubMed PMID: 26645690; PubMed Central PMCID: PMC4742767. 4: Al Maruf A, O'Brien P. Flutamide-induced cytotoxicity and oxidative stress in an in vitro rat hepatocyte system. Oxid Med Cell Longev. 2014;2014:398285. doi: 10.1155/2014/398285. Epub 2014 Oct 13. PubMed PMID: 25371773; PubMed Central PMCID: PMC4211152. 5: Al Maruf A, Wan L, O'Brien PJ. Evaluation of azathioprine-induced cytotoxicity in an in vitro rat hepatocyte system. Biomed Res Int. 2014;2014:379748. doi: 10.1155/2014/379748. Epub 2014 Jul 1. PubMed PMID: 25101277; PubMed Central PMCID: PMC4101230. 6: Matsumoto M, Yamaguchi M, Yoshida Y, Senuma M, Takashima H, Kawamura T, Kato H, Takahashi M, Hirata-Koizumi M, Ono A, Yokoyama K, Hirose A. An antioxidant, N,N'-diphenyl-p-phenylenediamine (DPPD), affects labor and delivery in rats: a 28-day repeated dose test and reproduction/developmental toxicity test. Food Chem Toxicol. 2013 Jun;56:290-6. doi: 10.1016/j.fct.2013.02.029. Epub 2013 Feb 26. PubMed PMID: 23454298. 7: Sawada H, Tsuzuki-ishi T, Kijima T, Kawakami J, Iizuka M, Yoshida M. Controlling photochromism between fluoroalkyl end-capped oligomer/polyaniline and N,N'-diphenyl-1,4-phenylenediamine nanocomposites induced by UV-light-responsive titanium oxide nanoparticles. J Colloid Interface Sci. 2011 Jul 15;359(2):461-6. doi: 10.1016/j.jcis.2011.03.090. Epub 2011 Apr 12. PubMed PMID: 21529818. 8: Dal Ponte C, Alchera E, Follenzi A, Imarisio C, Prat M, Albano E, Carini R. Pharmacological postconditioning protects against hepatic ischemia/reperfusion injury. Liver Transpl. 2011 Apr;17(4):474-82. doi: 10.1002/lt.22256. PubMed PMID: 21445931. 9: Ahmed EA, Omar HM, elghaffar SKh, Ragb SM, Nasser AY. The antioxidant activity of vitamin C, DPPD and L-cysteine against Cisplatin-induced testicular oxidative damage in rats. Food Chem Toxicol. 2011 May;49(5):1115-21. doi: 10.1016/j.fct.2011.02.002. Epub 2011 Feb 15. PubMed PMID: 21310208. 10: Kawai Y, Satoh T, Hibi D, Ohno Y, Kohda Y, Miura K, Gemba M. The effect of antioxidant on development of fibrosis by cisplatin in rats. J Pharmacol Sci. 2009 Dec;111(4):433-9. Epub 2009 Dec 5. PubMed PMID: 19966510. 11: Yamano T, Shimizu M. Skin sensitization potency and cross-reactivity of p-phenylenediamine and its derivatives evaluated by non-radioactive murine local lymph node assay and guinea-pig maximization test. Contact Dermatitis. 2009 Apr;60(4):193-8. doi: 10.1111/j.1600-0536.2008.01500.x. PubMed PMID: 19338586. 12: Rankin GO, Hong SK, Anestis DK, Ball JG, Valentovic MA. Mechanistic aspects of 4-amino-2,6-dichlorophenol-induced in vitro nephrotoxicity. Toxicology. 2008 Mar 12;245(1-2):123-9. doi: 10.1016/j.tox.2007.12.014. Epub 2007 Dec 27. PubMed PMID: 18243470. 13: Ji X, Compton RG. Determination of ammonia based on the electrochemical oxidation of N,N'-diphenyl-1,4-phenylenediamine in propylene carbonate. Anal Sci. 2007 Nov;23(11):1317-20. PubMed PMID: 17998752. 14: Satoh T, Izumi M. Neuroprotective effects of phenylenediamine derivatives independent of an antioxidant pathway in neuronal HT22 cells. Neurosci Lett. 2007 May 11;418(1):102-5. Epub 2007 Mar 12. PubMed PMID: 17400379. 15: Berry EV, Toms NJ. Pyruvate and oxaloacetate limit zinc-induced oxidative HT-22 neuronal cell injury. Neurotoxicology. 2006 Dec;27(6):1043-51. Epub 2006 May 22. PubMed PMID: 16797712. 16: Kawai Y, Nakao T, Kunimura N, Kohda Y, Gemba M. Relationship of intracellular calcium and oxygen radicals to Cisplatin-related renal cell injury. J Pharmacol Sci. 2006 Jan;100(1):65-72. Epub 2006 Jan 13. PubMed PMID: 16410676. 17: Su JM, Wang LY, Liang YL, Zha XL. Role of cell adhesion signal molecules in hepatocellular carcinoma cell apoptosis. World J Gastroenterol. 2005 Aug 14;11(30):4667-73. PubMed PMID: 16094707; PubMed Central PMCID: PMC4615408. 18: Matsunaga Y, Kawai Y, Kohda Y, Gemba M. Involvement of activation of NADPH oxidase and extracellular signal-regulated kinase (ERK) in renal cell injury induced by zinc. J Toxicol Sci. 2005 May;30(2):135-44. PubMed PMID: 15928461. 19: Conde-Salazar L, Valks R, Acebes CG, Bertó J. Occupational allergic contact dermatitis from antioxidant amines in a dental technician. Dermatitis. 2004 Dec;15(4):197-200. PubMed PMID: 15842064. 20: Svedman C, Isaksson M, Zimerson E, Bruze M. Occupational contact dermatitis from a grease. Dermatitis. 2004 Mar;15(1):41-4. PubMed PMID: 15573647.