MedKoo Cat#: 562830 | Name: TC-Mps1-12
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Description:

WARNING: This product is for research use only, not for human or veterinary use.

TC-Mps1-12 is a potent and selective monopolar spindle 1 (Mps1) inhibitor.

Chemical Structure

TC-Mps1-12
TC-Mps1-12
CAS#1206170-62-8

Theoretical Analysis

MedKoo Cat#: 562830

Name: TC-Mps1-12

CAS#: 1206170-62-8

Chemical Formula: C17H20N6O

Exact Mass: 324.1699

Molecular Weight: 324.38

Elemental Analysis: C, 62.95; H, 6.21; N, 25.91; O, 4.93

Price and Availability

Size Price Availability Quantity
10mg USD 500.00 2 Weeks
50mg USD 1,200.00 2 Weeks
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Related CAS #
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Synonym
TC-Mps1-12; TC Mps1 12; TCMps112; TC-Mps1 12;
IUPAC/Chemical Name
4-[[4-Amino-5-cyano-6-[(1,1-dimethylethyl)amino]-2-pyridinyl]amino]benzamide
InChi Key
XDEFNAWAKYQBQY-UHFFFAOYSA-N
InChi Code
InChI=1S/C17H20N6O/c1-17(2,3)23-16-12(9-18)13(19)8-14(22-16)21-11-6-4-10(5-7-11)15(20)24/h4-8H,1-3H3,(H2,20,24)(H4,19,21,22,23)
SMILES Code
O=C(N)C1=CC=C(NC2=NC(NC(C)(C)C)=C(C#N)C(N)=C2)C=C1
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>2 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 324.38 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Uitdehaag JCM, de Man J, Willemsen-Seegers N, Prinsen MBW, Libouban MAA, Sterrenburg JG, de Wit JJP, de Vetter JRF, de Roos JADM, Buijsman RC, Zaman GJR. Target Residence Time-Guided Optimization on TTK Kinase Results in Inhibitors with Potent Anti-Proliferative Activity. J Mol Biol. 2017 Jul 7;429(14):2211-2230. doi: 10.1016/j.jmb.2017.05.014. Epub 2017 May 21. PMID: 28539250. 2: Choi M, Min YH, Pyo J, Lee CW, Jang CY, Kim JE. TC Mps1 12, a novel Mps1 inhibitor, suppresses the growth of hepatocellular carcinoma cells via the accumulation of chromosomal instability. Br J Pharmacol. 2017 Jun;174(12):1810-1825. doi: 10.1111/bph.13782. Epub 2017 Apr 22. PMID: 28299790; PMCID: PMC5446587.