Iproniazid | CAS#54-92-2 | MAO inhibitor

MedKoo Cat#: 584442 | Name: Iproniazid

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Description:

WARNING: This product is for research use only, not for human or veterinary use.

Iproniazid is a non-selective, irreversible monoamine oxidase (MAO) inhibitor (MAOI) that is used as an antidepressive agent.

Chemical Structure

Iproniazid

CAS#54-92-2

Theoretical Analysis

MedKoo Cat#: 584442

Name: Iproniazid

CAS#: 54-92-2

Chemical Formula: C9H13N3O

Exact Mass: 179.1059

Molecular Weight: 179.22

Elemental Analysis: C, 60.32; H, 7.31; N, 23.45; O, 8.93

Price and Availability

Size	Price	Availability	Quantity
100mg	USD 330.00

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Related CAS #

No Data

Synonym

Iproniazid; Marsilid; Iprazid

IUPAC/Chemical Name

4-Pyridinecarboxylic acid, 2-(1-methylethyl)hydrazide

InChi Key

NYMGNSNKLVNMIA-UHFFFAOYSA-N

InChi Code

InChI=1S/C9H13N3O/c1-7(2)11-12-9(13)8-3-5-10-6-4-8/h3-7,11H,1-2H3,(H,12,13)

SMILES Code

O=C(C1=CC=NC=C1)NNC(C)C

Appearance

Solid powder

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

Soluble in DMSO

Shelf Life

>2 years if stored properly

Drug Formulation

This drug may be formulated in DMSO

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.9001

More Info

Product Data

Product Data

Instruction

View handling instruction

Biological target:

Iproniazid is a non-selective, irreversible monoamine oxidase (MAO) inhibitor of the hydrazine class. Iproniazid has antidepressive activity.

In vitro activity:

TBD

In vivo activity:

The irreversible inhibition of monoamine oxidase (MAO) inside and outside monoaminergic neurones in the rat brain by the suicide inhibitors clorgyline, selegiline (l-deprenyl), pheniprazine, phenelzine, iproniazid, pargyline and the d- and l-enantiomers of tranylcypromine was determined. Reference: Biochem Pharmacol. https://pubmed.ncbi.nlm.nih.gov/2870717/

	Solvent	mg/mL	mM
Solubility
	DMSO	67.5	376.63
	Ethanol	35.0	195.29
	Water	67.5	376.63

Note: There can be variations in solubility for the same chemical from different vendors or different batches from the same vendor. The following factors can affect the solubility of the same chemical: solvent used for crystallization, residual solvent content, polymorphism, salt versus free form, degree of hydration, solvent temperature. Please use the solubility data as a reference only. Warming and sonication will facilitate dissolving. Still have questions? Please contact our Technical Support scientists.

Preparing Stock Solutions

The following data is based on the product molecular weight 179.22 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

Formulation protocol:

1. Fagervall I, Ross SB. Inhibition of monoamine oxidase in monoaminergic neurones in the rat brain by irreversible inhibitors. Biochem Pharmacol. 1986 Apr 15;35(8):1381-7. doi: 10.1016/0006-2952(86)90285-6. PMID: 2870717.

In vitro protocol:

TBD

In vivo protocol:

[1] Shen W, et al. Molecules. 2014, 19(11):18620-31.