MedKoo Biosciences, Inc.
Tel:   +1-919-636-5577    Fax:   +1-919-980-4831    Email:   sales@medkoo.com
Search
Login Register
Search
MedKoo Cat#: 562824 | Name: tHGA

Description:

WARNING: This product is for research use only, not for human or veterinary use.

tHGA is a potent lipoxygenase (LOX) inhibitor.

Chemical Structure

tHGA
tHGA
CAS#43230-43-9

Theoretical Analysis

MedKoo Cat#: 562824

Name: tHGA

CAS#: 43230-43-9

Chemical Formula: C18H24O4

Exact Mass: 304.1675

Molecular Weight: 304.38

Elemental Analysis: C, 71.03; H, 7.95; O, 21.02

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
Bulk Inquiry
Related CAS #
No Data
Synonym
tHGA; t-HGA;
IUPAC/Chemical Name
(E)-1-(3-(3,7-dimethylocta-2,6-dien-1-yl)-2,4,6-trihydroxyphenyl)ethan-1-one
InChi Key
RCOXTTLIGHDQHU-XYOKQWHBSA-N
InChi Code
InChI=1S/C18H24O4/c1-11(2)6-5-7-12(3)8-9-14-15(20)10-16(21)17(13(4)19)18(14)22/h6,8,10,20-22H,5,7,9H2,1-4H3/b12-8+
SMILES Code
OC1=CC(O)=C(C/C=C(C)/CC/C=C(C)/C)C(O)=C1C(C)=O
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>2 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 304.38 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Lee YZ, Yap HM, Shaari K, Tham CL, Sulaiman MR, Israf DA. Blockade of Eosinophil-Induced Bronchial Epithelial-Mesenchymal Transition with a Geranyl Acetophenone in a Coculture Model. Front Pharmacol. 2017 Nov 16;8:837. doi: 10.3389/fphar.2017.00837. eCollection 2017. PubMed PMID: 29201006; PubMed Central PMCID: PMC5696322. 2: Tan JW, Israf DA, Md Hashim NF, Cheah YK, Harith HH, Shaari K, Tham CL. LAT is essential for the mast cell stabilising effect of tHGA in IgE-mediated mast cell activation. Biochem Pharmacol. 2017 Nov 15;144:132-148. doi: 10.1016/j.bcp.2017.08.010. Epub 2017 Aug 13. PubMed PMID: 28813645. 3: Tan JW, Israf DA, Harith HH, Md Hashim NF, Ng CH, Shaari K, Tham CL. Anti-allergic activity of 2,4,6-trihydroxy-3-geranylacetophenone (tHGA) via attenuation of IgE-mediated mast cell activation and inhibition of passive systemic anaphylaxis. Toxicol Appl Pharmacol. 2017 Mar 15;319:47-58. doi: 10.1016/j.taap.2017.02.002. Epub 2017 Feb 4. PubMed PMID: 28167223. 4: Lee YZ, Shaari K, Cheema MS, Tham CL, Sulaiman MR, Israf DA. An orally active geranyl acetophenone attenuates airway remodeling in a murine model of chronic asthma. Eur J Pharmacol. 2017 Feb 15;797:53-64. doi: 10.1016/j.ejphar.2017.01.011. Epub 2017 Jan 12. PubMed PMID: 28089919. 5: Chong YJ, Musa NF, Ng CH, Shaari K, Israf DA, Tham CL. Barrier protective effects of 2,4,6-trihydroxy-3-geranyl acetophenone on lipopolysaccharides-stimulated inflammatory responses in human umbilical vein endothelial cells. J Ethnopharmacol. 2016 Nov 4;192:248-255. doi: 10.1016/j.jep.2016.07.032. Epub 2016 Jul 9. PubMed PMID: 27404229. 6: Mukherjee AK, Manna SK, Roy SK, Chakraborty M, Das S, Naskar JP. Plasma-aminothiols status and inverse correlation of total homocysteine with B-vitamins in arsenic exposed population of West Bengal, India. J Environ Sci Health A Tox Hazard Subst Environ Eng. 2016 Sep 18;51(11):962-73. doi: 10.1080/10934529.2016.1191816. Epub 2016 Jun 23. PubMed PMID: 27336853. 7: Ng CH, Rullah K, Aluwi MF, Abas F, Lam KW, Ismail IS, Narayanaswamy R, Jamaludin F, Shaari K. Synthesis and docking studies of 2,4,6-trihydroxy-3-geranylacetophenone analogs as potential lipoxygenase inhibitor. Molecules. 2014 Aug 5;19(8):11645-59. doi: 10.3390/molecules190811645. PubMed PMID: 25100256. 8: House E, Polwart A, Darbre P, Barr L, Metaxas G, Exley C. The aluminium content of breast tissue taken from women with breast cancer. J Trace Elem Med Biol. 2013 Oct;27(4):257-66. doi: 10.1016/j.jtemb.2013.05.002. Epub 2013 Jun 1. PubMed PMID: 23870171. 9: Dürr KL, Tavraz NN, Spiller S, Friedrich T. Measuring cation transport by Na,K- and H,K-ATPase in Xenopus oocytes by atomic absorption spectrophotometry: an alternative to radioisotope assays. J Vis Exp. 2013 Feb 19;(72):e50201. doi: 10.3791/50201. PubMed PMID: 23462593; PubMed Central PMCID: PMC3605618. 10: Ismail N, Jambari NN, Zareen S, Akhtar MN, Shaari K, Zamri-Saad M, Tham CL, Sulaiman MR, Lajis NH, Israf DA. A geranyl acetophenone targeting cysteinyl leukotriene synthesis prevents allergic airway inflammation in ovalbumin-sensitized mice. Toxicol Appl Pharmacol. 2012 Mar 1;259(2):257-62. doi: 10.1016/j.taap.2012.01.003. Epub 2012 Jan 12. PubMed PMID: 22266348. 11: Shaari K, Suppaiah V, Wai LK, Stanslas J, Tejo BA, Israf DA, Abas F, Ismail IS, Shuaib NH, Zareen S, Lajis NH. Bioassay-guided identification of an anti-inflammatory prenylated acylphloroglucinol from Melicope ptelefolia and molecular insights into its interaction with 5-lipoxygenase. Bioorg Med Chem. 2011 Nov 1;19(21):6340-7. doi: 10.1016/j.bmc.2011.09.001. Epub 2011 Sep 10. PubMed PMID: 21958738. 12: Burrell SA, Exley C. There is (still) too much aluminium in infant formulas. BMC Pediatr. 2010 Aug 31;10:63. doi: 10.1186/1471-2431-10-63. PubMed PMID: 20807425; PubMed Central PMCID: PMC2939626. 13: Raschzok N, Billecke N, Kammer NN, Morgul MH, Adonopoulou MK, Sauer IM, Florek S, Becker-Ross H, Huang MD. Quantification of cell labeling with micron-sized iron oxide particles using continuum source atomic absorption spectrometry. Tissue Eng Part C Methods. 2009 Dec;15(4):681-6. doi: 10.1089/ten.tec.2008.0675. PubMed PMID: 19422300. 14: Dash K, Thangavel S, Chaurasia SC, Arunachalam J. Determination of indium in high purity antimony by electrothermal atomic absorption spectrometry (ETAAS) using boric acid as a modifier. Talanta. 2006 Oct 15;70(3):602-8. doi: 10.1016/j.talanta.2006.01.022. Epub 2006 Feb 21. PubMed PMID: 18970815. 15: Karadjova IB, Lampugnani L, Tsalev DL. Electrothermal atomic absorption spectrometric determination of arsenic in essential lavender and rose oils. Talanta. 2005 Feb 28;65(4):1015-21. doi: 10.1016/j.talanta.2004.08.035. PubMed PMID: 18969904. 16: Volynsky AB, Wennrich R. Efficiency of Pt and Ir modifiers for the simultaneous determination of As, Se and In in a sodium sulphate matrix by electrothermal atomic absorption spectrometry. Talanta. 2003 Feb 6;59(2):277-86. PubMed PMID: 18968909. 17: Correia PR, de Oliveira E, Oliveira PV. Simultaneous determination of manganese and selenium in serum by electrothermal atomic absorption spectrometry. Talanta. 2002 May 24;57(3):527-35. PubMed PMID: 18968652. 18: Chan MS, Huang SD. Direct determination of cadmium and copper in seawater using a transversely heated graphite furnace atomic absorption spectrometer with Zeeman-effect background corrector. Talanta. 2000 Feb 7;51(2):373-80. PubMed PMID: 18967869. 19: Ajtony Z, Szoboszlai N, Suskó EK, Mezei P, György K, Bencs L. Direct sample introduction of wines in graphite furnace atomic absorption spectrometry for the simultaneous determination of arsenic, cadmium, copper and lead content. Talanta. 2008 Jul 30;76(3):627-34. doi: 10.1016/j.talanta.2008.04.014. Epub 2008 Apr 16. PubMed PMID: 18585331. 20: Rodney E, Herrera P, Luxama J, Boykin M, Crawford A, Carroll MA, Catapane EJ. Bioaccumulation and Tissue Distribution of Arsenic, Cadmium, Copper and Zinc in Crassostrea virginica Grown at Two Different Depths in Jamaica Bay, New York. In Vivo (Brooklyn). 2007 Fall;29(1):16-27. PubMed PMID: 21841973; PubMed Central PMCID: PMC3155416.