MedKoo Cat#: 562823 | Name: H2-005

Description:

WARNING: This product is for research use only, not for human or veterinary use.

H2-005 is a class of selective diacylglycerol acyltransferase 2 (DGAT2) inhibitor.

Chemical Structure

H2-005
H2-005
CAS#1060478-12-7

Theoretical Analysis

MedKoo Cat#: 562823

Name: H2-005

CAS#: 1060478-12-7

Chemical Formula: C24H32N4O4

Exact Mass: 440.2424

Molecular Weight: 440.54

Elemental Analysis: C, 65.43; H, 7.32; N, 12.72; O, 14.53

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
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Related CAS #
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Synonym
H2-005; H2 005; H2005;
IUPAC/Chemical Name
5-[(1-Ethylpropyl)amino]-3-[(2-furanylcarbonyl)amino]-1-(3-methylbutyl)-1H-pyrrolo[2,3-b]pyridine-2-carboxylic acid methyl ester
InChi Key
OKGKSBUMLPRLOR-UHFFFAOYSA-N
InChi Code
InChI=1S/C24H32N4O4/c1-6-16(7-2)26-17-13-18-20(27-23(29)19-9-8-12-32-19)21(24(30)31-5)28(11-10-15(3)4)22(18)25-14-17/h8-9,12-16,26H,6-7,10-11H2,1-5H3,(H,27,29)
SMILES Code
O=C(C1=C(NC(C2=CC=CO2)=O)C3=CC(NC(CC)CC)=CN=C3N1CCC(C)C)OC
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>2 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 440.54 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Shortell SM, Addicott R, Walsh N, Ham C. The NHS five year forward view: lessons from the United States in developing new care models. BMJ. 2015 Apr 21;350:h2005. doi: 10.1136/bmj.h2005. PubMed PMID: 25899794. 2: Martinez-Lemus LA, Zhao G, Galiñanes EL, Boone M. Inward remodeling of resistance arteries requires reactive oxygen species-dependent activation of matrix metalloproteinases. Am J Physiol Heart Circ Physiol. 2011 Jun;300(6):H2005-15. doi: 10.1152/ajpheart.01066.2010. Epub 2011 Apr 1. PubMed PMID: 21460197; PubMed Central PMCID: PMC3119084. 3: Wang Y, Chen AF, Wang DH. ET(A) receptor blockade prevents renal dysfunction in salt-sensitive hypertension induced by sensory denervation. Am J Physiol Heart Circ Physiol. 2005 Nov;289(5):H2005-11. Epub 2005 Jul 1. PubMed PMID: 15994858. 4: Song Y, Belardinelli L. ATP promotes development of afterdepolarizations and triggered activity in cardiac myocytes. Am J Physiol. 1994 Nov;267(5 Pt 2):H2005-11. PubMed PMID: 7526716.