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MedKoo Cat#: 596298 | Name: JS-38

Description:

WARNING: This product is for research use only, not for human or veterinary use.

JS-38 is a synthetic version of a metabolite isolated from Xenorhabdus sp.

Chemical Structure

JS-38
JS-38
CAS#608131-69-7

Theoretical Analysis

MedKoo Cat#: 596298

Name: JS-38

CAS#: 608131-69-7

Chemical Formula: C22H14F6N2O4S2

Exact Mass: 548.0299

Molecular Weight: 548.47

Elemental Analysis: C, 48.18; H, 2.57; F, 20.78; N, 5.11; O, 11.67; S, 11.69

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
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Related CAS #
No Data
Synonym
JS-38; JS 38; JS38;
IUPAC/Chemical Name
N-(4-(2,4-dimethoxyphenyl)-5-oxo-4,5-dihydro-[1,2]dithiolo[4,3-b]pyrrol-6-yl)-3,5-bis(trifluoromethyl)benzamide
InChi Key
QOWQCUJERUFFPS-UHFFFAOYSA-N
InChi Code
InChI=1S/C22H14F6N2O4S2/c1-33-13-3-4-14(16(8-13)34-2)30-15-9-35-36-18(15)17(20(30)32)29-19(31)10-5-11(21(23,24)25)7-12(6-10)22(26,27)28/h3-9H,1-2H3,(H,29,31)
SMILES Code
O=C(NC1=C2C(N(C3=CC=C(OC)C=C3OC)C1=O)=CSS2)C4=CC(C(F)(F)F)=CC(C(F)(F)F)=C4
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>2 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 548.47 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Liu MY, Xiao L, Chen GH, Wang YX, Xiong WX, Li F, Liu Y, Huang XL, Deng YF, Zhang Z, Sun HY, Liu QH, Yin M. Oral JS-38, a metabolite from Xenorhabdus sp., has both anti-tumor activity and the ability to elevate peripheral neutrophils. Chin J Nat Med. 2014 Oct;12(10):768-76. doi: 10.1016/S1875-5364(14)60117-5. Epub 2014 Oct 31. PubMed PMID: 25443370. 2: Zhang H, Liu Q, Fan T, Fang Y, Li Y, Wang G. Metabolism and disposition of a novel antineoplastic JS-38 (Benzamide, N-[4-(2,4-dimethoxyphenyl)-4,5-dihydro-5-oxo-1,2-dithiolo[4,3-b]pyrrol-6-yl]-3,5- bis (trifluoromethyl)-(9Cl)) in rats. Eur J Drug Metab Pharmacokinet. 2012 Mar;37(1):45-56. doi: 10.1007/s13318-011-0055-8. Epub 2011 Jul 30. PubMed PMID: 21805208. 3: Ng HZ, Fang Y, Li Y, Fan TT, Qin Y, Liu QH. The pharmacokinetics of JS-38, a novel antineoplastic drug, in rats. Eur J Drug Metab Pharmacokinet. 2008 Jul-Sep;33(3):143-8. PubMed PMID: 19007039.