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MedKoo Cat#: 596264 | Name: Iodothiouracil

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Iodothiouracil is a uracil derivative used as a thyroid antagonist.

Chemical Structure

Iodothiouracil
Iodothiouracil
CAS#5984-97-4

Theoretical Analysis

MedKoo Cat#: 596264

Name: Iodothiouracil

CAS#: 5984-97-4

Chemical Formula: C4H3IN2OS

Exact Mass: 253.9011

Molecular Weight: 254.04

Elemental Analysis: C, 18.91; H, 1.19; I, 49.95; N, 11.03; O, 6.30; S, 12.62

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
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Related CAS #
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Synonym
Iodothiouracil; Jodthiouracilum; Iothiouracil;
IUPAC/Chemical Name
5-iodo-2-thioxo-2,3-dihydropyrimidin-4(1H)-one
InChi Key
MYUHSNVSHMCUMD-UHFFFAOYSA-N
InChi Code
InChI=1S/C4H3IN2OS/c5-2-1-6-4(9)7-3(2)8/h1H,(H2,6,7,8,9)
SMILES Code
S=C(N1)NC=C(I)C1=O
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>2 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 254.04 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Mårs U, Tolmachev V, Sundin A. Positron emission tomography of experimental melanoma with. Nucl Med Biol. 2000 Nov;27(8):845-9. PubMed PMID: 11150719. 2: Olander K, Larsson BS, Ringborg U, Schnell PO. Uptake of [131I]thiouracil in tumours of patients with disseminated malignant melanoma. A pilot study. Melanoma Res. 1992 Jan-Feb;1(5-6):391-5. PubMed PMID: 1422195. 3: Coderre JA, Halle DA. Direct electrophilic iodination of 2-thiouracil using Iodo-Gen. Int J Rad Appl Instrum A. 1989;40(9):759-63. PubMed PMID: 2559065. 4: van Langevelde A, Bergman W, Feitsma RI, Osanto S, Pauwels EK. A patient study with radioiodine labelled 5-iodo-2-thiouracil. Eur J Nucl Med. 1988;14(12):640-1. PubMed PMID: 3243315. 5: Franken NA, Van Langevelde A, Pauwels EK, Journée-de Korver JG, Bakker CN, Oosterhuis JA. Radio-iodine-labelled 5-iodo-2-thiouracil: a potential radiopharmaceutical for establishing the viability of ocular melanoma after radiation therapy. Nucl Med Commun. 1986 Nov;7(11):797-809. PubMed PMID: 3554049. 6: Coderre JA, Packer S, Fairchild RG, Greenberg D, Laster B, Micca P, Fand I. Iodothiouracil as a melanoma localizing agent. J Nucl Med. 1986 Jul;27(7):1157-64. PubMed PMID: 3723191. 7: Franken NA, van Delft JL, van Langevelde A, Bleeker JC, de Wolff-Rouendaal D, van Best JA, Bouwhuis-Hoogerwerf ML, Oosterhuis JA, Pauwels EK. Scintimetric detection of choroidal malignant melanoma with [123I]-5-iodo-2-thiouracil. Ophthalmologica. 1986;193(4):248-54. PubMed PMID: 3587880. 8: Franken NA, Van Langevelde A, Journée-De Korver JG, Bakker CN, Feitsma RI, Van Delft JL, Oosterhuis JA, Pauwels EK. Uptake of 123I-5-iodo-2-thiouracil, a possible radiopharmaceutical for noninvasive detection of ocular melanoma, in melanotic and amelanotic melanomas in hamsters. Nucl Med Commun. 1985 Oct;6(10):657-63. PubMed PMID: 4088550. 9: Broxterman HJ, van Langevelde A, Bakker CN, Boer H, Journée-de Korver JG, Kaspersen FM, Kakebeeke-Kemme HM, Pauwels EK. Incorporation of [125I]-5-iodo-2-thiouracil in cultured hamster, rabbit, and human melanoma cells. Cancer Res. 1983 Mar;43(3):1316-20. PubMed PMID: 6825101. 10: van Langevelde A, Bakker CN, Broxterman HJ, Journée-de Korver JG, Kaspersen FM, Oosterhuis JA, Pauwels EK. Potential radiopharmaceuticals for the detection of ocular melanoma. Part I. 5-iodo-2-thiouracil derivatives. Eur J Nucl Med. 1983;8(2):45-51. PubMed PMID: 6840126. 11: SARCIONE EJ, BARRETT HW. The antithyroid activity of 5-iodo-2-thiouracil. Endocrinology. 1958 Aug;63(2):142-50. PubMed PMID: 13562017. 12: MONEY WL, GODWIN JT, RAWSON RW. The experimental production of thyroid tumors in the rat by the administration of sodium-5-iodo-2-thiouracil. Cancer. 1957 Jul-Aug;10(4):690-7. PubMed PMID: 13472603. 13: VILLARI V, CORAGGIO F. [In vitro antibacterial activity of 5-iodo-2-thiouracil]. Riv Ist Sieroter Ital. 1957 Jan-Feb;32(1):35-43. Italian. PubMed PMID: 13421484. 14: LAMBERG BA, WAHLBERG P. [Potassium perchlorate and iodothiouracil in thyrotoxicosis]. Nord Med. 1955 Mar 3;53(9):359-61. Swedish. PubMed PMID: 14356503. 15: DE RITIS F, ROSSANO P. [Therapy of hyperthyroidism with 5-iodo-2-thiouracil]. Minerva Med. 1954 Apr 7;45(28):955-65. Undetermined Language. PubMed PMID: 13165271. 16: GALBRAITH HJ, NASH DF, SPENCE AW. Iodothiouracil in treatment of toxic goitre. Br Med J. 1954 Feb 20;1(4859):420-2. PubMed PMID: 13126529; PubMed Central PMCID: PMC2084533. 17: GOLDBERG RC, WOLFF J. Evaluation of the antithyroid activity of 5-iodo-2-thiouracil. Endocrinology. 1954 Feb;54(2):181-95. PubMed PMID: 13151109. 18: VANDERLAAN WP, CAPLAN R. On the mode of action of iodothiouracil. J Clin Endocrinol Metab. 1954 Feb;14(2):232-41. PubMed PMID: 13130670. 19: CATZ B. Additive toxic effects of phenobarbital and itrumil. J Clin Endocrinol Metab. 1953 Sep;13(9):1128-9. PubMed PMID: 13084734. 20: CATZ B, STARR P. Metabolic, isotopic, and pathological differences between sodium-5-iodo-2-thiouracil and thiouracil plus potassium iodide. Am J Med Sci. 1953 Feb;225(2):178-86. PubMed PMID: 13016559.