Synonym
Acetrizoate sodium; MP 1023; MP-1023; MP1023; Reopak; Diaginol; Sodium acetrizoate;
IUPAC/Chemical Name
sodium 3-acetamido-2,4,6-triiodobenzoate
InChi Key
UCPVOMHRDXMAIZ-UHFFFAOYSA-M
InChi Code
InChI=1S/C9H6I3NO3.Na/c1-3(14)13-8-5(11)2-4(10)6(7(8)12)9(15)16;/h2H,1H3,(H,13,14)(H,15,16);/q;+1/p-1
SMILES Code
O=C([O-])C1=C(I)C=C(I)C(NC(C)=O)=C1I.[Na+]
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>2 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
Preparing Stock Solutions
The following data is based on the
product
molecular weight
578.84
Batch specific molecular weights may vary
from batch to batch
due to the degree of hydration, which will
affect the solvent
volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass |
1 mg |
5 mg |
10 mg |
| 1 mM |
1.15 mL |
5.76 mL |
11.51 mL |
| 5 mM |
0.23 mL |
1.15 mL |
2.3 mL |
| 10 mM |
0.12 mL |
0.58 mL |
1.15 mL |
| 50 mM |
0.02 mL |
0.12 mL |
0.23 mL |
1: Cheng KT. N,N´-Bis(2,3-dihydroxypropyl)-5-[N-(2-hydroxye thyl-3-methoxypropyl)-acetamidol]-2,4,6-triiodoisophthalamide. 2006 Mar 6 [updated 2008 Mar 4]. In: Molecular Imaging and Contrast Agent Database (MICAD) [Internet]. Bethesda (MD): National Center for Biotechnology Information (US); 2004–2013. PMID: 20641971.
2: TABAC. Cancer Bull. 1950 Jul-Aug;2(4):77. PMID: 14772699.
3: Cheng KT. 5-[3-Hydroxy-2-hydroxymethyl-propionamido)-N,N´-dimet hyl-N,N´-bis-(2,3-dihydroxypropyl)-2,4,6-triiodoisophthalamide. 2006 May 16 [updated 2008 Apr 21]. In: Molecular Imaging and Contrast Agent Database (MICAD) [Internet]. Bethesda (MD): National Center for Biotechnology Information (US); 2004–2013. PMID: 20641966.
4: Cheng KT. N,N´-Bis(2,3-dihydroxypropyl)-5-[N-(2-hydroxyethyl)-g lycolamidol]-2,4,6-triiodoisophthalamide. 2006 Feb 7 [updated 2008 Feb 7]. In: Molecular Imaging and Contrast Agent Database (MICAD) [Internet]. Bethesda (MD): National Center for Biotechnology Information (US); 2004–2013. PMID: 20641970.
5: JONES MD, STEINBACH HL, RAPHAEL RL. Sodium amidotrizoate (hypaque) and sodium acetrizoate (urokon); comparison of efficacy in intravenous urography. AMA Arch Surg. 1956 Jul;73(1):99-104. doi: 10.1001/archsurg.1956.01280010101013. PMID: 13326019.
6: SEAMAN WB, SCHWARTZ HG. Cerebral arteriography with sodium acetrizoate (urokon sodium) 30%. AMA Arch Surg. 1953 Nov;67(5):741-5. doi: 10.1001/archsurg.1953.01260040752012. PMID: 13103941.
7: DOEHNER GA, BRUGGER GE. Comparison of diatrizoate methylglucamine, sodium acetrizoate, and diatrizoate sodium in cerebral angiography. N Y State J Med. 1960 Dec 15;60:4022-4. PMID: 13723380.
8: Saxton HM. Review article: urography. Br J Radiol. 1969 May;42(497):321-46. doi: 10.1259/0007-1285-42-497-321. PMID: 4914357.
9: ORLOFF TL. Intravenous cholecystography with a new medium; experience with sodium acetrizoate (urokon sodium) seventy per cent. AMA Arch Surg. 1955 Oct;71(4):620-2. doi: 10.1001/archsurg.1955.01270160146019. PMID: 13258064.
10: WOOLLEY IM, KEIZUR LW, MAYERHARNISCH G. Gallbladder visualization following the use of 70 per cent sodium acetrizoate (urokon sodium) for intravenous pyelography. Radiology. 1957 Oct;69(4):576-7. doi: 10.1148/69.4.576. PMID: 13485425.
11: GREEN B, SOWERBUTTS JG. A comparative study of the value of sodium acetrizoate (diaginol) 50 per cent and sodium diatrizoate (hypaque) 45 per cent in intravenous urography. Br J Radiol. 1956 Mar;29(339):161-5. doi: 10.1259/0007-1285-29-339-161. PMID: 13304289.
12: NEW and nonofficial remedies; sodium acetrizoate; urokon sodium. J Am Med Assoc. 1950 Oct 21;144(8):623. PMID: 14774151.
13: The MICAD Research Team. N-(2,3-Dihydroxypropyl)-N´-(2-hydroxy ethyl)-5-[N-(2,3-dihydroxypropyl)acetamido]-2,4,6-triiodoisophthalamide. 2006 Jul 12 [updated 2006 Aug 9]. In: Molecular Imaging and Contrast Agent Database (MICAD) [Internet]. Bethesda (MD): National Center for Biotechnology Information (US); 2004–2013. PMID: 20641973.
14: USE OF sodium acetrizoate for cerebral angiography. J Am Med Assoc. 1956 Sep 1;162(1):37. PMID: 13357287.
15: KEATES PG. An assessment of sodium acetrizoate and an experimental basis for its use in intravenous pyelography. J Fac Radiol. 1955 Oct;7(2):139-46. doi: 10.1016/s0368-2242(55)80008-5. PMID: 24543829.
16: LINDGREN P, NORDENSTROM B, TORNELL G. Arterial spasm treated with sodium acetrizoate. Acta Chir Scand Suppl. 1959;Suppl 245:351-6. PMID: 14417151.
17: GANDINI D, ORSO GP. L'aceterizoato di sodio nelle ricerche urografiche e pielochimografiche [Sodium acetrizoate in urographic and pyelokymographic research]. Arch Ital Urol. 1957;30(2):119-43. Italian. PMID: 13445431.
18: USE OF sodium acetrizoate for urethrography. J Am Med Assoc. 1957 May 18;164(3):282. PMID: 13415983.
19: SMITHAM JH. A viscous solution of sodium acetrizoate as a medium for hysterosalpingography. Br J Radiol. 1959 Mar;32(375):193-7. doi: 10.1259/0007-1285-32-375-193. PMID: 13638540.
20: LANCE EM, KILLEN DA, SCOTT HW Jr. A plea for caution in the use of sodium acetrizoate (urokon) for aortography. Ann Surg. 1959 Jul;150(1):172. doi: 10.1097/00000658-195907000-00022. PMID: 13661846; PMCID: PMC1613496.
