MedKoo Cat#: 596255 | Name: Tixocortol pivalate
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Description:

WARNING: This product is for research use only, not for human or veterinary use.

Tixocortol pivalate is a corticosteroid. It has anti-inflammatory properties similar to hydrocortisone. It is marketed under the brand name Pivalone.

Chemical Structure

Tixocortol pivalate
CAS#55560-96-8

Theoretical Analysis

MedKoo Cat#: 596255

Name: Tixocortol pivalate

CAS#: 55560-96-8

Chemical Formula: C26H38O5S

Exact Mass: 462.2440

Molecular Weight: 462.64

Elemental Analysis: C, 67.50; H, 8.28; O, 17.29; S, 6.93

Price and Availability

Size Price Availability Quantity
10mg USD 450.00 2 Weeks
100mg USD 1,550.00
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Related CAS #
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Synonym
Tixocortol pivalate; Pivalone; JO 1016; JO-1016; JO1016;
IUPAC/Chemical Name
S-(2-((8S,9S,10R,11S,13S,14S,17R)-11,17-dihydroxy-10,13-dimethyl-3-oxo-2,3,6,7,8,9,10,11,12,13,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-17-yl)-2-oxoethyl) 2,2-dimethylpropanethioate
InChi Key
BISFDZNIUZIKJD-XDANTLIUSA-N
InChi Code
InChI=1S/C26H38O5S/c1-23(2,3)22(30)32-14-20(29)26(31)11-9-18-17-7-6-15-12-16(27)8-10-24(15,4)21(17)19(28)13-25(18,26)5/h12,17-19,21,28,31H,6-11,13-14H2,1-5H3/t17-,18-,19-,21+,24-,25-,26-/m0/s1
SMILES Code
C[C@@]12[C@](C(CSC(C(C)(C)C)=O)=O)(O)CC[C@@]1([H])[C@]3([H])CCC4=CC(CC[C@]4(C)[C@@]3([H])[C@@H](O)C2)=O
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>2 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info
Certificate of Analysis
Safety Data Sheet (SDS)

Preparing Stock Solutions

The following data is based on the product molecular weight 462.64 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Frankild S, Lepoittevin JP, Kreilgaard B, Andersen KE. Tixocortol pivalate contact allergy in the GPMT: frequency and cross-reactivity. Contact Dermatitis. 2001 Jan;44(1):18-22. doi: 10.1034/j.1600-0536.2001.440104.x. PMID: 11156006. 2: Rousselin Y, Yolka S, Clavel A. Crystal structures of two polymorphs of tixocortol pivalate. Acta Crystallogr E Crystallogr Commun. 2021 Jul 16;77(Pt 8):809-813. doi: 10.1107/S2056989021007167. PMID: 34422306; PMCID: PMC8340970. 3: Lutz ME, el-Azhary RA, Gibson LE, Fransway AF. Contact hypersensitivity to tixocortol pivalate. J Am Acad Dermatol. 1998 May;38(5 Pt 1):691-5. doi: 10.1016/s0190-9622(98)70197-5. PMID: 9591812. 4: Friedman G. Tixocortol Pivalate (JO 1016). Am J Gastroenterol. 1983 Aug;78(8):529-30. PMID: 6410909. 5: Larochelle P, Du Souich P, Bolte E, Lelorier J, Goyer R. Tixocortol pivalate, a corticosteroid with no systemic glucocorticoid effect after oral, intrarectal, and intranasal application. Clin Pharmacol Ther. 1983 Mar;33(3):343-50. doi: 10.1038/clpt.1983.43. PMID: 6402333. 6: Isaksson M. Corticosteroids. Dermatol Ther. 2004;17(4):314-20. doi: 10.1111/j.1396-0296.2004.04036.x. PMID: 15327476. 7: Mirshahpanah P, Maibach HI. Guinea pig maximization test assessment of hydrocortisone and tixocortol pivalate. Cutan Ocul Toxicol. 2007;26(4):375-82. doi: 10.1080/15569520701662775. PMID: 18058310. 8: Lelièvre V, Junien JL, Goyer R, Russo-Marie F. Affinity of tixocortol pivalate (JO 1016), tixocortol, cortisol acetate and cortisol for dexamethasone receptors of mouse thymus cells and rat renomedullary interstitial cells in culture. Correlation with their biological activities. J Steroid Biochem. 1984 Jan;20(1):363-6. doi: 10.1016/0022-4731(84)90234-6. PMID: 6584691. 9: Shaw DW, Maibach HI. Clinical relevance of tixocortol pivalate-positive patch tests and questionable bioequivalence of different hydrocortisone preparations. Contact Dermatitis. 2013 Jun;68(6):369-75. doi: 10.1111/cod.12066. PMID: 23692037. 10: Uphill PF, Poole A. A comparison of the effects of tixocortol pivalate (JO 1016), hydrocortisone acetate and beclomethasone dipropionate on the phagocytosis and lysis of microorganisms by alveolar macrophages. Arzneimittelforschung. 1981;31(3):462-6. PMID: 6784736.