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MedKoo Cat#: 596195 | Name: JB 1-0

Description:

WARNING: This product is for research use only, not for human or veterinary use.

JB 1-0 is a bioactive chemical.

Chemical Structure

JB 1-0
JB 1-0
CAS#78617-10-4

Theoretical Analysis

MedKoo Cat#: 596195

Name: JB 1-0

CAS#: 78617-10-4

Chemical Formula: C17H22BrNO3

Exact Mass: 367.0783

Molecular Weight: 368.27

Elemental Analysis: C, 55.44; H, 6.02; Br, 21.70; N, 3.80; O, 13.03

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
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Related CAS #
No Data
Synonym
JB 1-0;
IUPAC/Chemical Name
4-(2-bromo-4,5-dimethoxyphenyl)octahydro-2H-quinolizin-2-one
InChi Key
GBSNIMKWBQIPII-UHFFFAOYSA-N
InChi Code
InChI=1S/C17H22BrNO3/c1-21-16-9-13(14(18)10-17(16)22-2)15-8-12(20)7-11-5-3-4-6-19(11)15/h9-11,15H,3-8H2,1-2H3
SMILES Code
O=C1CC2CCCCN2C(C3=CC(OC)=C(OC)C=C3Br)C1
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>2 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 368.27 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Gao QG, Xie JX, Wong MS, Chen WF. IGF-I receptor signaling pathway is involved in the neuroprotective effect of genistein in the neuroblastoma SK-N-SH cells. Eur J Pharmacol. 2012 Feb 29;677(1-3):39-46. doi: 10.1016/j.ejphar.2011.12.032. Epub 2011 Dec 29. PubMed PMID: 22227334. 2: Rainsford KD. Effects of anti-inflammatory drugs and agents that modify intracellular transduction signals or metabolic activities in inflammatory cells on interleukin-1 induced cartilage proteoglycan resorption in vitro. Pharmacol Res. 1992 May-Jun;25(4):335-46. PubMed PMID: 1329061. 3: Lema WJ, Blankenship JW, Malone MH. Prostaglandin synthetase inhibition by alkaloids of Heimia salicifolia. J Ethnopharmacol. 1986 Feb;15(2):161-7. PubMed PMID: 3086627. 4: Byrne JA, Malone MH, Quick J, Meltzer PC. Evaluation of four homologs of 4-(2-bromo-4,5-dimethoxyphenyl)-octahydro-2H-quinolizin-2-one (JB-1-0) for their capacity to prevent carrageenan induced pedal edema in the rat. Proc West Pharmacol Soc. 1984;27:293-6. PubMed PMID: 6494167. 5: Malone MH, Quick J, Meltzer PC. Relative protective effects of 20 homologs of 4-(2-bromo-4,5-dimethoxyphenyl)-octahydro-2H-quinolizin-2-one (JB-1-0) against croton oil induced inflammation in mice. Proc West Pharmacol Soc. 1983;26:351-5. PubMed PMID: 6889363.

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L 689660