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MedKoo Cat#: 596176 | Name: Prothioconazole
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Description:

WARNING: This product is for research use only, not for human or veterinary use.

Prothioconazole is a chiral triazole fungicide.

Chemical Structure

Prothioconazole
Prothioconazole
CAS#178928-70-6

Theoretical Analysis

MedKoo Cat#: 596176

Name: Prothioconazole

CAS#: 178928-70-6

Chemical Formula: C14H15Cl2N3OS

Exact Mass: 343.0313

Molecular Weight: 344.25

Elemental Analysis: C, 48.85; H, 4.39; Cl, 20.60; N, 12.21; O, 4.65; S, 9.31

Price and Availability

Size Price Availability Quantity
100mg USD 550.00
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Related CAS #
No Data
Synonym
Prothioconazole; JAU 6476; Proline 480 SC Fungicide; HSDB 7893; HSDB-7893; HSDB7893; JAU 6476; JAU6476; JAU-6476;
IUPAC/Chemical Name
2-(2-(1-chlorocyclopropyl)-3-(2-chlorophenyl)-2-hydroxypropyl)-1,2-dihydro-3H-1,2,4-triazole-3-thione
InChi Key
MNHVNIJQQRJYDH-UHFFFAOYSA-N
InChi Code
InChI=1S/C14H15Cl2N3OS/c15-11-4-2-1-3-10(11)7-14(20,13(16)5-6-13)8-19-12(21)17-9-18-19/h1-4,9,20H,5-8H2,(H,17,18,21)
SMILES Code
S=C1N(CC(O)(C2(Cl)CC2)CC3=CC=CC=C3Cl)NC=N1
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>2 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 344.25 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Soto ER, Rus F, Ostroff GR. Yeast Particle Encapsulation of Azole Fungicides for Enhanced Treatment of Azole-Resistant Candida albicans. J Funct Biomater. 2024 Jul 23;15(8):203. doi: 10.3390/jfb15080203. PMID: 39194641. 2: Kato AY, Freitas TAL, Gomes CRA, Alves TRR, Ferraz YMM, Trivellato MF, De Jong D, Biller JD, Nicodemo D. Bixafen, Prothioconazole, and Trifloxystrobin Alone or in Combination Have a Greater Effect on Health Related Gene Expression in Honey Bees from Nutritionally Deprived than from Protein Supplemented Colonies. Insects. 2024 Jul 11;15(7):523. doi: 10.3390/insects15070523. PMID: 39057256; PMCID: PMC11277445. 3: Rangel LI, Wyatt N, Courneya I, Natwick MB, Secor GA, Rivera-Varas V, Bolton MD. CbCyp51-mediated DMI resistance is modulated by codon bias. Phytopathology. 2024 Jul 15. doi: 10.1094/PHYTO-01-24-0034-R. Epub ahead of print. PMID: 39007764. 4: Aatif HM, Saeed S, Ali Y, Iqbal S, Shahid Hanif CM, Ahmad S, Raza A, Sanchez Lucas R, Ali H, Fahad Alrefaei A, Mahmood Sheikh TM. Genotypes, epidemiological variables and fungicides application associated with wheat leaf rust development and grain yield. Heliyon. 2024 Jun 7;10(12):e32564. doi: 10.1016/j.heliyon.2024.e32564. PMID: 38952372; PMCID: PMC11215259. 5: Vyas NB, Henry PFP, Binkowski ŁJ, Hladik ML, Gross MS, Schroeder MA, Davis DM. Persistence of pesticide residues in weathered avian droppings. Environ Res. 2024 Jun 28;259:119475. doi: 10.1016/j.envres.2024.119475. Epub ahead of print. PMID: 38945513. 6: Arendrup MC, Hare RK, Jørgensen KM, Bollmann UE, Bech TB, Hansen CC, Heick TM, Jørgensen LN. Environmental Hot Spots and Resistance-Associated Application Practices for Azole-Resistant Aspergillus fumigatus, Denmark, 2020-2023. Emerg Infect Dis. 2024 Aug;30(8):1531-1541. doi: 10.3201/eid3008.240096. Epub 2024 Jun 27. PMID: 38935978; PMCID: PMC11286046. 7: Ren XX, Chen L, Yu-Chi, Zhao-Li, Su XY, Shun-He, Ye ZH. Development and application of a novel suspension concentrate for seed coating of rice for controlling bakanae disease and seedling rot disease. Front Bioeng Biotechnol. 2024 Jun 6;12:1418313. doi: 10.3389/fbioe.2024.1418313. PMID: 38903191; PMCID: PMC11187768. 8: Guo Z, Deng M, Fang W, Zheng K, Liao M, Wang Y, Fang Q. Quantitative determination of prothioconazole in wheat grain, soybean, and pond water based on a polyclonal antibody. Anal Methods. 2024 Jun 27;16(25):4074-4082. doi: 10.1039/d4ay00441h. PMID: 38855900. 9: Debler F, Abrantes N, Harkes P, Campos I, Gandrass J. Occurrence and distribution of pesticides and transformation products in ambient air in two European agricultural areas. Sci Total Environ. 2024 Aug 25;940:173705. doi: 10.1016/j.scitotenv.2024.173705. Epub 2024 Jun 1. PMID: 38830419. 10: Wang L, Tao X, Lin Z, Song N, Wu H, Mingrong Q. Enantioselective toxicity assessment of prothioconazole on earthworms (Eisenia foetida) in artificial soil environments. Comp Biochem Physiol C Toxicol Pharmacol. 2024 Sep;283:109941. doi: 10.1016/j.cbpc.2024.109941. Epub 2024 May 27. PMID: 38810898. 11: Campani T, Casini S, Maccantelli A, Tosoni F, D'Agostino A, Caliani I. Oxidative stress and DNA alteration on the earthworm Eisenia fetida exposed to four commercial pesticides. Environ Sci Pollut Res Int. 2024 May;31(24):35969-35978. doi: 10.1007/s11356-024-33511-7. Epub 2024 May 14. PMID: 38743332; PMCID: PMC11136830. 12: Pütsepp R, Mäe A, Põllumaa L, Andresen L, Kiiker R. Fungicide Sensitivity Profile of Pyrenophora teres f. teres in Field Population. J Fungi (Basel). 2024 Mar 29;10(4):260. doi: 10.3390/jof10040260. PMID: 38667932; PMCID: PMC11051325. 13: Zhang C, Liu Z, Yang Y, Ma Q, Zheng Y, Xu C, Gao X, Gao W, Huang Z, Liu X. Characterization of Fusarium species causing soybean root rot in Heilongjiang, China, and mechanism underlying the differences in sensitivity to DMI fungicides. Pestic Biochem Physiol. 2024 Mar;200:105828. doi: 10.1016/j.pestbp.2024.105828. Epub 2024 Feb 12. PMID: 38582592. 14: Navarro I, de la Torre A, Sanz P, Abrantes N, Campos I, Alaoui A, Christ F, Alcon F, Contreras J, Glavan M, Pasković I, Pasković MP, Nørgaard T, Mandrioli D, Sgargi D, Hofman J, Aparicio V, Baldi I, Bureau M, Vested A, Harkes P, Huerta-Lwanga E, Mol H, Geissen V, Silva V, Martínez MÁ. Assessing pesticide residues occurrence and risks in water systems: A Pan-European and Argentina perspective. Water Res. 2024 May 1;254:121419. doi: 10.1016/j.watres.2024.121419. Epub 2024 Mar 7. PMID: 38484551. 15: Fernández-Vizcaíno E, Mateo R, Fernández de Mera IG, Mougeot F, Camarero PR, Ortiz-Santaliestra ME. Transgenerational effects of triazole fungicides on gene expression and egg compounds in non-exposed offspring: A case study using Red- Legged Partridges (Alectoris rufa). Sci Total Environ. 2024 May 20;926:171546. doi: 10.1016/j.scitotenv.2024.171546. Epub 2024 Mar 12. PMID: 38479527. 16: Matelionienė N, Žvirdauskienė R, Kadžienė G, Zavtrikovienė E, Supronienė S. In Vitro Sensitivity Test of Fusarium Species from Weeds and Non- Gramineous Plants to Triazole Fungicides. Pathogens. 2024 Feb 10;13(2):160. doi: 10.3390/pathogens13020160. PMID: 38392898; PMCID: PMC10892909. 17: Niu J, Wang C, Qiao K, Liao M, Liu Y, Ding Y, Yao H, Zhang H, Cao H. Quaternized chitosan-based organic-inorganic nanohybrid nanoparticles loaded with prothioconazole for efficient management of fungal diseases with minimal environmental impact. Int J Biol Macromol. 2024 Mar;262(Pt 2):129662. doi: 10.1016/j.ijbiomac.2024.129662. Epub 2024 Jan 22. PMID: 38266842. 18: Zhang M, Wang W, Zhang D, Zhang Y, Li Y, Fang F, Zhang Z, Zhang Y. Prothioconazole exposure disrupts oocyte maturation and fertilization by inducing mitochondrial dysfunction and apoptosis in mice. Free Radic Biol Med. 2024 Mar;213:274-284. doi: 10.1016/j.freeradbiomed.2024.01.027. Epub 2024 Jan 18. PMID: 38244729. 19: Hu L, Wang X, Qian M, Zhang H, Jin Y. Impacts of prothioconazole and prothioconazole-desthio on bile acid and glucolipid metabolism: Upregulation of CYP7A1 expression in HepG2 cells. Pestic Biochem Physiol. 2024 Jan;198:105702. doi: 10.1016/j.pestbp.2023.105702. Epub 2023 Nov 28. PMID: 38225060. 20: Zhou F, Jiao Y, Han A, Zhou X, Kong J, Hu H, Liu R, Li C. Survey of prothioconazole sensitivity in Fusarium pseudograminearum isolates from Henan Province, China, and characterization of resistant laboratory mutants. BMC Plant Biol. 2024 Jan 4;24(1):29. doi: 10.1186/s12870-023-04714-w. PMID: 38172651; PMCID: PMC10765739.