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MedKoo Cat#: 596167 | Name: Trifluoperazine hydrochloride
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Description:

WARNING: This product is for research use only, not for human or veterinary use.

Trifluoperazine hydrochloride is a typical antipsychotic primarily used to treat schizophrenia. It may also be used short term in those with generalized anxiety disorder but is less preferred to benzodiazepines. It is of the phenothiazine chemical class.

Chemical Structure

Trifluoperazine hydrochloride
Trifluoperazine hydrochloride
CAS#440-17-5

Theoretical Analysis

MedKoo Cat#: 596167

Name: Trifluoperazine hydrochloride

CAS#: 440-17-5

Chemical Formula: C21H26Cl2F3N3S

Exact Mass: 479.1177

Molecular Weight: 480.41

Elemental Analysis: C, 52.50; H, 5.46; Cl, 14.76; F, 11.86; N, 8.75; S, 6.67

Price and Availability

Size Price Availability Quantity
5g USD 260.00
10g USD 430.00
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Related CAS #
No Data
Synonym
Trifluoperazine hydrochloride; NSC 17474; NSC-17474; NSC17474; Trifluoperazine HCl; Tryptazine dihydrochloride; SKF 5019; Trazine;
IUPAC/Chemical Name
10-(3-(4-methylpiperazin-1-yl)propyl)-2-(trifluoromethyl)-10H-phenothiazine dihydrochloride
InChi Key
BXDAOUXDMHXPDI-UHFFFAOYSA-N
InChi Code
InChI=1S/C21H24F3N3S.2ClH/c1-25-11-13-26(14-12-25)9-4-10-27-17-5-2-3-6-19(17)28-20-8-7-16(15-18(20)27)21(22,23)24;;/h2-3,5-8,15H,4,9-14H2,1H3;2*1H
SMILES Code
FC(C(C=C1N2CCCN3CCN(C)CC3)=CC=C1SC4=C2C=CC=C4)(F)F.[H]Cl.[H]Cl
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>2 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info
Certificate of Analysis
View CoA: current batch, Lot#A22K07S16
Safety Data Sheet (SDS)
View Safety Data Sheet (SDS)
Instruction
View handling instruction

Preparing Stock Solutions

The following data is based on the product molecular weight 480.41 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Bryan EJ, Purcell MA, Kumar A. Zuclopenthixol dihydrochloride for schizophrenia. Cochrane Database Syst Rev. 2017 Nov 16;11:CD005474. doi: 10.1002/14651858.CD005474.pub2. Review. PubMed PMID: 29144549. 2: Hummels H, Bertholee D, van der Meer D, Smit JP, Wilffert B, Ter Horst P. The quality of lactation studies including antipsychotics. Eur J Clin Pharmacol. 2016 Dec;72(12):1417-1425. Epub 2016 Aug 24. Review. PubMed PMID: 27558359. 3: Temmingh H, Stein DJ. Anxiety in Patients with Schizophrenia: Epidemiology and Management. CNS Drugs. 2015;29(10):819-32. doi: 10.1007/s40263-015-0282-7. Review. PubMed PMID: 26482261. 4: Kristiansen JE, Dastidar SG, Palchoudhuri S, Roy DS, Das S, Hendricks O, Christensen JB. Phenothiazines as a solution for multidrug resistant tuberculosis: From the origin to present. Int Microbiol. 2015 Mar;18(1):1-12. doi: 10.2436/20.1501.01.229. Review. PubMed PMID: 26415662. 5: Dold M, Samara MT, Li C, Tardy M, Leucht S. Haloperidol versus first-generation antipsychotics for the treatment of schizophrenia and other psychotic disorders. Cochrane Database Syst Rev. 2015 Jan 16;1:CD009831. doi: 10.1002/14651858.CD009831.pub2. Review. PubMed PMID: 25592299. 6: Parikh T, Goyal D, Scarff JR, Lippmann S. Antipsychotic drugs and safety concerns for breast-feeding infants. South Med J. 2014 Nov;107(11):686-8. doi: 10.14423/SMJ.0000000000000190. Review. PubMed PMID: 25365434. 7: Tardy M, Dold M, Engel RR, Leucht S. Trifluoperazine versus low-potency first-generation antipsychotic drugs for schizophrenia. Cochrane Database Syst Rev. 2014 Jul 8;(7):CD009396. doi: 10.1002/14651858.CD009396.pub2. Review. PubMed PMID: 25003310. 8: Koch K, Mansi K, Haynes E, Adams CE, Sampson S, Furtado VA. Trifluoperazine versus placebo for schizophrenia. Cochrane Database Syst Rev. 2014 Jan 11;(1):CD010226. doi: 10.1002/14651858.CD010226.pub2. Review. PubMed PMID: 24414883. 9: Lauterbach EC. Neuroprotective effects of psychotropic drugs in Huntington's disease. Int J Mol Sci. 2013 Nov 15;14(11):22558-603. doi: 10.3390/ijms141122558. Review. PubMed PMID: 24248060; PubMed Central PMCID: PMC3856079. 10: Berchtold MW, Villalobo A. The many faces of calmodulin in cell proliferation, programmed cell death, autophagy, and cancer. Biochim Biophys Acta. 2014 Feb;1843(2):398-435. doi: 10.1016/j.bbamcr.2013.10.021. Epub 2013 Nov 2. Review. PubMed PMID: 24188867. 11: Klinger G, Stahl B, Fusar-Poli P, Merlob P. Antipsychotic drugs and breastfeeding. Pediatr Endocrinol Rev. 2013 Mar-Apr;10(3):308-17. Review. PubMed PMID: 23724438. 12: Gale CK, Millichamp J. Generalised anxiety disorder. BMJ Clin Evid. 2011 Oct 27;2011. pii: 1002. Review. PubMed PMID: 22030083; PubMed Central PMCID: PMC3275153. 13: Bola J, Kao D, Soydan H. Antipsychotic medication for early episode schizophrenia. Cochrane Database Syst Rev. 2011 Jun 15;(6):CD006374. doi: 10.1002/14651858.CD006374.pub2. Review. PubMed PMID: 21678355; PubMed Central PMCID: PMC4105695. 14: van Ingen J. The broad-spectrum antimycobacterial activities of phenothiazines, InVitro: somewhere in all of this there may be patentable potentials. Recent Pat Antiinfect Drug Discov. 2011 May;6(2):104-9. Review. PubMed PMID: 21517740. 15: Yap YG, Behr ER, Camm AJ. Drug-induced Brugada syndrome. Europace. 2009 Aug;11(8):989-94. doi: 10.1093/europace/eup114. Epub 2009 May 29. Review. PubMed PMID: 19482855. 16: Einarson A, Boskovic R. Use and safety of antipsychotic drugs during pregnancy. J Psychiatr Pract. 2009 May;15(3):183-92. doi: 10.1097/01.pra.0000351878.45260.94. Review. PubMed PMID: 19461391. 17: Kopeĭko GI, Oleĭchik IV. [Contribution of pubertal psychobiological processes to the formation and clinical manifestations of juvenile depressions]. Zh Nevrol Psikhiatr Im S S Korsakova. 2007;107(3):4-17. Review. Russian. PubMed PMID: 18379507. 18: Hatano E. Tumor necrosis factor signaling in hepatocyte apoptosis. J Gastroenterol Hepatol. 2007 Jun;22 Suppl 1:S43-4. Review. Erratum in: J Gastroenterol Hepatol. 2008 Mar;23(3):501-2. PubMed PMID: 17567463. 19: Gale CK, Millichamp J. Generalised anxiety disorder. BMJ Clin Evid. 2007 Nov 20;2007. pii: 1002. Review. PubMed PMID: 19450347; PubMed Central PMCID: PMC2943796. 20: Gutiérrez-Correa J. Trypanosoma cruzi dihydrolipoamide dehydrogenase as target for phenothiazine cationic radicals. Effect of antioxidants. Curr Drug Targets. 2006 Sep;7(9):1155-79. Review. PubMed PMID: 17017892.

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