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MedKoo Cat#: 562774 | Name: Oncrasin-72

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Oncrasin-72 is an analogue of oncrasin-1 with antitumor activity mediated by JNK activation and STAT3 inhibition.

Chemical Structure

Oncrasin-72
Oncrasin-72
CAS#92407-90-4

Theoretical Analysis

MedKoo Cat#: 562774

Name: Oncrasin-72

CAS#: 92407-90-4

Chemical Formula: C16H14ClNO

Exact Mass: 271.0764

Molecular Weight: 271.74

Elemental Analysis: C, 70.72; H, 5.19; Cl, 13.05; N, 5.15; O, 5.89

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
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Related CAS #
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Synonym
Oncrasin-72; Oncrasin 72; Oncrasin72; NSC-743380; NSC 743380; NSC743380;
IUPAC/Chemical Name
1-[(3-Chlorophenyl) methyl]-1H-indole-3-methanol
InChi Key
LPIARNOLFFSUSO-UHFFFAOYSA-N
InChi Code
InChI=1S/C16H14ClNO/c17-14-5-3-4-12(8-14)9-18-10-13(11-19)15-6-1-2-7-16(15)18/h1-8,10,19H,9,11H2
SMILES Code
OCC1=CN(CC2=CC=CC(Cl)=C2)C3=C1C=CC=C3
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>2 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 271.74 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: White L, Wu S, Ma J, Fang B, Liang D. Simultaneous determination and validation of oncrasin-266 and its metabolites by HPLC-MS/MS: Application to a pharmacokinetic study. J Chromatogr B Analyt Technol Biomed Life Sci. 2016 Oct 15;1033-1034:106-111. doi: 10.1016/j.jchromb.2016.07.033. Epub 2016 Aug 10. PubMed PMID: 27541624; PubMed Central PMCID: PMC5045800. 2: Wu S, Wang L, Huang X, Cao M, Hu J, Li H, Zhang H, Sun X, Meng QH, Hofstetter WL, Roth JA, Swisher SG, Fang B. Prodrug oncrasin-266 improves the stability, pharmacokinetics, and safety of NSC-743380. Bioorg Med Chem. 2014 Oct 1;22(19):5234-40. doi: 10.1016/j.bmc.2014.08.006. Epub 2014 Aug 14. PubMed PMID: 25182964; PubMed Central PMCID: PMC4172508. 3: Guo W, Wu S, Wang L, Wei X, Liu X, Wang J, Lu Z, Hollingshead M, Fang B. Antitumor activity of a novel oncrasin analogue is mediated by JNK activation and STAT3 inhibition. PLoS One. 2011;6(12):e28487. doi: 10.1371/journal.pone.0028487. Epub 2011 Dec 12. PubMed PMID: 22174819; PubMed Central PMCID: PMC3236185.