NSC-741909 | CAS#92407-91-5 | anticancer agent

MedKoo Cat#: 562773 | Name: NSC-741909

Description:

WARNING: This product is for research use only, not for human or veterinary use.

NSC-741909 is an anticancer agent. It acts by suppressing the growth of several cell lines derived from lung, colon, breast, ovarian, and kidney cancers.

Chemical Structure

NSC-741909

CAS#92407-91-5

Theoretical Analysis

MedKoo Cat#: 562773

Name: NSC-741909

CAS#: 92407-91-5

Chemical Formula: C16H14ClNO

Exact Mass: 271.0764

Molecular Weight: 271.74

Elemental Analysis: C, 70.72; H, 5.19; Cl, 13.05; N, 5.15; O, 5.89

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.

Bulk Inquiry

Related CAS #

No Data

Synonym

NSC-741909; NSC 741909; NSC741909;

IUPAC/Chemical Name

[1-[(4-chlorophenyl)methyl]indol-3-yl]methanol

InChi Key

WOUBLGRNDINCJL-UHFFFAOYSA-N

InChi Code

InChI=1S/C16H14ClNO/c17-14-7-5-12(6-8-14)9-18-10-13(11-19)15-3-1-2-4-16(15)18/h1-8,10,19H,9,11H2

SMILES Code

OCC1=CN(CC2=CC=C(Cl)C=C2)C3=C1C=CC=C3

Appearance

Solid powder

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

Soluble in DMSO

Shelf Life

>2 years if stored properly

Drug Formulation

This drug may be formulated in DMSO

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.9001

More Info

Instruction

View handling instruction

Preparing Stock Solutions

The following data is based on the product molecular weight 271.74 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

1: Guo W, Wu S, Wang L, Wei X, Liu X, Wang J, Lu Z, Hollingshead M, Fang B. Antitumor activity of a novel oncrasin analogue is mediated by JNK activation and STAT3 inhibition. PLoS One. 2011;6(12):e28487. doi: 10.1371/journal.pone.0028487. Epub 2011 Dec 12. PubMed PMID: 22174819; PubMed Central PMCID: PMC3236185. 2: Guo W, Wei X, Wu S, Wang L, Peng H, Wang J, Fang B. Antagonistic effect of flavonoids on NSC-741909-mediated antitumor activity via scavenging of reactive oxygen species. Eur J Pharmacol. 2010 Dec 15;649(1-3):51-8. doi: 10.1016/j.ejphar.2010.08.057. Epub 2010 Sep 18. PubMed PMID: 20854805; PubMed Central PMCID: PMC2967662. 3: Wei X, Guo W, Wu S, Wang L, Huang P, Liu J, Fang B. Oxidative stress in NSC-741909-induced apoptosis of cancer cells. J Transl Med. 2010 Apr 16;8:37. doi: 10.1186/1479-5876-8-37. PubMed PMID: 20398386; PubMed Central PMCID: PMC2873373. 4: Wei X, Guo W, Wu S, Wang L, Lu Y, Xu B, Liu J, Fang B. Inhibiting JNK dephosphorylation and induction of apoptosis by novel anticancer agent NSC-741909 in cancer cells. J Biol Chem. 2009 Jun 19;284(25):16948-55. doi: 10.1074/jbc.M109.010256. Epub 2009 May 4. PubMed PMID: 19414586; PubMed Central PMCID: PMC2719332.