Synonym
Flumethiazide; NSC 44626; NSC-44626; NSC44626
IUPAC/Chemical Name
4H-1,2,4-Benzothiadiazine-7-sulfonamide, 6-(trifluoromethyl)-, 1,1-dioxide
InChi Key
RGUQWGXAYZNLMI-UHFFFAOYSA-N
InChi Code
InChI=1S/C8H6F3N3O4S2/c9-8(10,11)4-1-5-7(2-6(4)19(12,15)16)20(17,18)14-3-13-5/h1-3H,(H,13,14)(H2,12,15,16)
SMILES Code
O=S(C1=C(C(F)(F)F)C=C(C2=C1)NC=NS2(=O)=O)(N)=O
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>2 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
Preparing Stock Solutions
The following data is based on the
product
molecular weight
329.27
Batch specific molecular weights may vary
from batch to batch
due to the degree of hydration, which will
affect the solvent
volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass |
1 mg |
5 mg |
10 mg |
| 1 mM |
1.15 mL |
5.76 mL |
11.51 mL |
| 5 mM |
0.23 mL |
1.15 mL |
2.3 mL |
| 10 mM |
0.12 mL |
0.58 mL |
1.15 mL |
| 50 mM |
0.02 mL |
0.12 mL |
0.23 mL |
1: Khodakivs'kyĭ OA. [Characteristics of antiischemic and nootropic properties of ademol in a rat model of acute brain ischemia]. Fiziol Zh. 2013;59(5):71-7. Ukrainian. PubMed PMID: 24400568.
2: Khodakivs'kyĭ OA, Pavlov SV, Bukhtiiarova NV. [Influence of ademol on NO metabolism indices in rats with modeling myocardial infarction]. Ukr Biokhim Zh (1999). 2013 May-Jun;85(3):85-9. Ukrainian. PubMed PMID: 23937052.
3: Sieh DH, Perlman S. Mechanism for the high bias in the USP colorimetric assay for diazotizable substances in hydrochlorothiazide. J Pharm Sci. 1984 Nov;73(11):1545-7. PubMed PMID: 6394743.
4: HODGKINSON CP 2nd, INCH FA, SNEED RJ. Effects of flumethiazide, hydrochlorothiazide and acetazolamide on the intraocular pressure of rabbits receiving fludrocortisone. Am J Ophthalmol. 1963 Mar;55:583-8. PubMed PMID: 13963793.
5: FEARON HD, LEWNES GC, CHU D. Effects of flumethiazide therapy on serum electrolyte levels. N Y State J Med. 1961 Apr 15;61:1249-54. PubMed PMID: 13698488.
6: FLAKE EB. Clinical experience with Rauwolfia-flumethiazide (Rautrax) in the treatment of arterial hypertension. J La State Med Soc. 1961 Apr;113:153-6. PubMed PMID: 13700111.
7: HUTCHISON JC, LUTZ RB Jr. Treatment of hypertension with Rauwolfia and flumethiazide. Pa Med J. 1960 Dec;63:1782-9. PubMed PMID: 13717062.
8: BAIN GP, LINDSEY S. Clinical experience with a new Rauwolfia-flumethiazide preparation. A preliminary report. JAMA. 1960 Aug 6;173:1577-9. PubMed PMID: 13795892.
9: NESCHE GE. A new antihypertensive agent. Clinical evaluation of a Rauwolfia-flumethiazide combination (rautrax). Calif Med. 1960 Jul;93:29-31. PubMed PMID: 14426568; PubMed Central PMCID: PMC1578247.
10: POUTSIAKA JW, PIALA JJ, SMITH CI, BURKE JC, THOMAS BG. Pharmacologic studies of flumethiazide (ademol). J Pharmacol Exp Ther. 1960 Apr;128:405-13. PubMed PMID: 14434532.
11: LOTTERHOS WE. Evaluation of Rauwolfia serpentina with flumethiazide in hypertension. J Miss State Med Assoc. 1960 Apr;1:151-3. PubMed PMID: 14418394.
12: FORD RV. Comparative effects on urinary electrolyte excretion following two benzothiadiazine diuretics, flumethiazide and chlorothiazide. Am J Med Sci. 1960 Feb;239:165-6. PubMed PMID: 13823918.
13: FUCHS M, MALLIN SR, IRIE S, LIPPMANN E. Diuretic effects of flumethiazide, a benzothiadiazine derivative. Postgrad Med. 1959 Dec;26:868-78. PubMed PMID: 13825522.
14: BODI T, FUCHS M, IRIE S, MOYER JH. Further observations on flumethiazide. A new oral diuretic agent. Am J Cardiol. 1959 Oct;4:464-9. PubMed PMID: 13801925.
15: COHEN BM. Flumethiazide, a new saluretic agent; its use in the office management of patients with moderately severe arterial hypertension. Mil Med. 1959 Aug;124(8):584-90. PubMed PMID: 13674075.
16: ROCHELLE JB 3rd, MONTERO AC, FORD RV. Observations on the use of flumethiazide in the treatment of edema. Antibiotic Med Clin Ther (New York). 1959 May;6(5):267-71. PubMed PMID: 13650504.
17: FUCHS M, BODI T, MOYER JH. Evaluation of flumethiazide (trifluoromethyl thiazide) in the outpatient clinic. Am J Cardiol. 1959 May;3(5):676-80. PubMed PMID: 13649594.
18: MONTERO AC, ROCHELLE JB 3rd, FORD RV. Use of flumethiazide as an adjunct to the therapy of hypertension. N Engl J Med. 1959 Apr 23;260(17):872-3. PubMed PMID: 13644607.
19: MONTERO AC, ROCHELLE JB 3rd, FORD RV. Clinical pharmacology of flumethiazide, a diuretic agent. Am Heart J. 1959 Apr;57(4):484-9. PubMed PMID: 13626810.
