ML387 | CAS#452077-89-3 | dehydrogenase inhibitor

MedKoo Cat#: 562756 | Name: ML387

Description:

WARNING: This product is for research use only, not for human or veterinary use.

ML387 is a human NAD(+)-dependent 15-hydroxyprostaglandin dehydrogenase inhibitor.

Chemical Structure

ML387

CAS#452077-89-3

Theoretical Analysis

MedKoo Cat#: 562756

Name: ML387

CAS#: 452077-89-3

Chemical Formula: C20H21N3O2

Exact Mass: 335.1634

Molecular Weight: 335.40

Elemental Analysis: C, 71.62; H, 6.31; N, 12.53; O, 9.54

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.

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Related CAS #

No Data

Synonym

ML387; ML-387; ML 387;

IUPAC/Chemical Name

[1-(4-Methoxyphenyl)benzimidazol-5-yl]-piperidin-1-ylmethanone

InChi Key

FUCWZIFGSAFUAO-UHFFFAOYSA-N

InChi Code

InChI=1S/C20H21N3O2/c1-25-17-8-6-16(7-9-17)23-14-21-18-13-15(5-10-19(18)23)20(24)22-11-3-2-4-12-22/h5-10,13-14H,2-4,11-12H2,1H3

SMILES Code

O=C(C1=CC=C2C(N=CN2C3=CC=C(OC)C=C3)=C1)N4CCCCC4

Appearance

Solid powder

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

Soluble in DMSO

Shelf Life

>2 years if stored properly

Drug Formulation

This drug may be formulated in DMSO

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.9001

More Info

Instruction

View handling instruction

Preparing Stock Solutions

The following data is based on the product molecular weight 335.40 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

1: Duveau DY, Yasgar A, Hu X, Kouznetsova J, Brimacombe KR, Kerns EH, Mathews L, Zhang X, Sun H, Ferrer M, Jadhav A, Simeonov A, Thomas CJ, Maloney DJ. Discovery of two small molecule inhibitors, ML387 and ML388, of human NAD(+)-dependent 15-hydroxyprostaglandin dehydrogenase. 2013 Dec 15 [updated 2015 Feb 11]. Probe Reports from the NIH Molecular Libraries Program [Internet]. Bethesda (MD): National Center for Biotechnology Information (US); 2010-. Available from http://www.ncbi.nlm.nih.gov/books/NBK280041/ PubMed PMID: 25834895.