Synonym
ADC-13; ADC13; ADC 13;
IUPAC/Chemical Name
1-Azabicyclo(3.2.0)heptane-2-carboxylic acid, 6-((1R)-1-hydroxyethyl)-3,7-dioxo-, (4-nitrophenyl)methyl ester, (5R,6S)-
p-Nitrobenzyl (5R,6S)-6-((1R)-1-hydroxyethyl)-2-oxocarbapenam-3-carboxylate
InChi Key
YBIDYTOJOXKBLO-USLOAXSXSA-N
InChi Code
InChI=1S/C16H16N2O7/c1-8(19)13-11-6-12(20)14(17(11)15(13)21)16(22)25-7-9-2-4-10(5-3-9)18(23)24/h2-5,8,11,13-14,19H,6-7H2,1H3/t8-,11-,13-,14?/m1/s1
SMILES Code
O=C(C(C(C[C@]1([H])[C@H]2[C@H](O)C)=O)N1C2=O)OCC3=CC=C([N+]([O-])=O)C=C3
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>2 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
Preparing Stock Solutions
The following data is based on the
product
molecular weight
348.31
Batch specific molecular weights may vary
from batch to batch
due to the degree of hydration, which will
affect the solvent
volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass |
1 mg |
5 mg |
10 mg |
| 1 mM |
1.15 mL |
5.76 mL |
11.51 mL |
| 5 mM |
0.23 mL |
1.15 mL |
2.3 mL |
| 10 mM |
0.12 mL |
0.58 mL |
1.15 mL |
| 50 mM |
0.02 mL |
0.12 mL |
0.23 mL |
1: de Veth MJ, Artegoitia VM, Campagna SR, Lapierre H, Harte F, Girard CL. Choline absorption and evaluation of bioavailability markers when supplementing choline to lactating dairy cows. J Dairy Sci. 2016 Dec;99(12):9732-9744. doi: 10.3168/jds.2016-11382. Epub 2016 Oct 19. PubMed PMID: 27771079.
2: Calistri L, Castellani A, Matteuzzi B, Mazzoni E, Pradella S, Colagrande S. Focal Liver Lesions Classification and Characterization: What Value Do DWI and ADC Have? J Comput Assist Tomogr. 2016 Sep-Oct;40(5):701-8. doi: 10.1097/RCT.0000000000000458. PubMed PMID: 27454786.
3: Yasuda S, Kojima A, Maeno Y, Oki N, Miyahara Y, Sudo T, Takekida S, Yamaguchi S, Nishimura R. Poor prognosis of patients with stage Ib1 adenosquamous cell carcinoma of the uterine cervix with pelvic lymphnode metastasis. Kobe J Med Sci. 2006;52(1-2):9-15. PubMed PMID: 16547424.
4: Wang T. High-performance liquid chromatographic separation of beta-methyl ADC-13 enolphosphate diphenyl ester and its alpha-methyl diastereomer. J Chromatogr A. 1997 Feb 21;762(1-2):327-33. PubMed PMID: 9098992.
