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MedKoo Cat#: 562753 | Name: SD-1029
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Description:

WARNING: This product is for research use only, not for human or veterinary use.

SD-1029 is a cell-permeable selective JAK2 inhibitor.

Chemical Structure

SD-1029
SD-1029
CAS#118372-34-2

Theoretical Analysis

MedKoo Cat#: 562753

Name: SD-1029

CAS#: 118372-34-2

Chemical Formula: C25H32Br2Cl2N2O3

Exact Mass: 0.0000

Molecular Weight: 639.25

Elemental Analysis: C, 46.97; H, 5.05; Br, 25.00; Cl, 11.09; N, 4.38; O, 7.51

Price and Availability

Size Price Availability Quantity
5mg USD 325.00 2 Weeks
10mg USD 550.00 2 Weeks
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Related CAS #
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Synonym
SD-1029; SD 1029; SD1029; NSC371488; NSC-371488; NSC 371488; JAK2 Inhibitor III;
IUPAC/Chemical Name
9-(3,4-Dichlorophenyl)-2,7-bis(dimethylaminomethyl)-3,4,5,6,7,9-hexahydro-2H-xanthene-1,8-dione dihydrobromide
InChi Key
INKLAKXQHDQKKZ-UHFFFAOYSA-N
InChi Code
InChI=1S/C25H30Cl2N2O3.2BrH/c1-28(2)12-15-6-9-19-22(24(15)30)21(14-5-8-17(26)18(27)11-14)23-20(32-19)10-7-16(25(23)31)13-29(3)4;;/h5,8,11,15-16,21H,6-7,9-10,12-13H2,1-4H3;2*1H
SMILES Code
O=C1C(C(C2=CC=C(Cl)C(Cl)=C2)C3=C(CCC(CN(C)C)C3=O)O4)=C4CCC1CN(C)C.[H]Br.[H]Br
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>2 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info
Product Data
Product Data
Instruction
View handling instruction
Biological target:
SD-1029 is a JAK2/STAT3 inhibitor and inhibits STAT3 nuclear translocation.
In vitro activity:
SD-1029 has potential as a therapeutic option for chordoma by inhibiting the STAT3 pathway. The growth of all three chordoma cell lines that were exposed to SD-1029 was inhibited. SD-1029 also inhibited STAT3 signaling cascade in all cell lines. Reference: Mol Cancer Ther. 2009 Sep;8(9):2597-605. https://pubmed.ncbi.nlm.nih.gov/19723879/
In vivo activity:
To be determined
Solvent mg/mL mM
Solubility
DMSO 10.0 15.64
Note: There can be variations in solubility for the same chemical from different vendors or different batches from the same vendor. The following factors can affect the solubility of the same chemical: solvent used for crystallization, residual solvent content, polymorphism, salt versus free form, degree of hydration, solvent temperature. Please use the solubility data as a reference only. Warming and sonication will facilitate dissolving. Still have questions? Please contact our Technical Support scientists.

Preparing Stock Solutions

The following data is based on the product molecular weight 639.25 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
1. Yang C, Schwab JH, Schoenfeld AJ, Hornicek FJ, Wood KB, Nielsen GP, Choy E, Mankin H, Duan Z. A novel target for treatment of chordoma: signal transducers and activators of transcription 3. Mol Cancer Ther. 2009 Sep;8(9):2597-605. doi: 10.1158/1535-7163.MCT-09-0504. Epub 2009 Sep 1. PMID: 19723879. 2. Duan Z, Bradner JE, Greenberg E, Levine R, Foster R, Mahoney J, Seiden MV. SD-1029 inhibits signal transducer and activator of transcription 3 nuclear translocation. Clin Cancer Res. 2006 Nov 15;12(22):6844-52. doi: 10.1158/1078-0432.CCR-06-1330. PMID: 17121906.
In vitro protocol:
1. Yang C, Schwab JH, Schoenfeld AJ, Hornicek FJ, Wood KB, Nielsen GP, Choy E, Mankin H, Duan Z. A novel target for treatment of chordoma: signal transducers and activators of transcription 3. Mol Cancer Ther. 2009 Sep;8(9):2597-605. doi: 10.1158/1535-7163.MCT-09-0504. Epub 2009 Sep 1. PMID: 19723879. 2. Duan Z, Bradner JE, Greenberg E, Levine R, Foster R, Mahoney J, Seiden MV. SD-1029 inhibits signal transducer and activator of transcription 3 nuclear translocation. Clin Cancer Res. 2006 Nov 15;12(22):6844-52. doi: 10.1158/1078-0432.CCR-06-1330. PMID: 17121906.
In vivo protocol:
To be determined
1: Duan Z, Bradner JE, Greenberg E, Levine R, Foster R, Mahoney J, Seiden MV. SD-1029 inhibits signal transducer and activator of transcription 3 nuclear translocation. Clin Cancer Res. 2006 Nov 15;12(22):6844-52. doi: 10.1158/1078-0432.CCR-06-1330. PMID: 17121906. 2: Andina N, Didichenko S, Schmidt-Mende J, Dahinden CA, Simon HU. Proviral integration site for Moloney murine leukemia virus 1, but not phosphatidylinositol-3 kinase, is essential in the antiapoptotic signaling cascade initiated by IL-5 in eosinophils. J Allergy Clin Immunol. 2009 Mar;123(3):603-11. doi: 10.1016/j.jaci.2008.12.004. Epub 2009 Jan 18. PMID: 19152965. 3: Yang C, Schwab JH, Schoenfeld AJ, Hornicek FJ, Wood KB, Nielsen GP, Choy E, Mankin H, Duan Z. A novel target for treatment of chordoma: signal transducers and activators of transcription 3. Mol Cancer Ther. 2009 Sep;8(9):2597-605. doi: 10.1158/1535-7163.MCT-09-0504. Epub 2009 Sep 1. PMID: 19723879. 4: Che Mat NF, Zhang X, Guzzo C, Gee K. Interleukin-23-induced interleukin-23 receptor subunit expression is mediated by the Janus kinase/signal transducer and activation of transcription pathway in human CD4 T cells. J Interferon Cytokine Res. 2011 Apr;31(4):363-71. doi: 10.1089/jir.2010.0083. Epub 2010 Dec 7. PMID: 21138378. 5: Liu Y, Liu A, Xu Z, Yu W, Wang H, Li C, Lin J. XZH-5 inhibits STAT3 phosphorylation and causes apoptosis in human hepatocellular carcinoma cells. Apoptosis. 2011 May;16(5):502-10. doi: 10.1007/s10495-011-0578-0. PMID: 21311975. 6: Jiang X, Kanda T, Wu S, Nakamoto S, Saito K, Shirasawa H, Kiyohara T, Ishii K, Wakita T, Okamoto H, Yokosuka O. Suppression of La antigen exerts potential antiviral effects against hepatitis A virus. PLoS One. 2014 Jul 7;9(7):e101993. doi: 10.1371/journal.pone.0101993. PMID: 24999657; PMCID: PMC4084951. 7: Zelano J, Larsson D, Kumlien E, Åsberg S. Pre-stroke seizures: A nationwide register-based investigation. Seizure. 2017 Jul;49:25-29. doi: 10.1016/j.seizure.2017.05.010. Epub 2017 May 17. PMID: 28544888. 8: Chen X, Chen H, He Y, Fu S, Liu H, Wang Q, Shen J. Proteomics-Guided Study on Buyang Huanwu Decoction for Its Neuroprotective and Neurogenic Mechanisms for Transient Ischemic Stroke: Involvements of EGFR/PI3K/Akt/Bad/14-3-3 and Jak2/Stat3/Cyclin D1 Signaling Cascades. Mol Neurobiol. 2020 Oct;57(10):4305-4321. doi: 10.1007/s12035-020-02016-y. Epub 2020 Jul 23. PMID: 32700252. 9: Fang J, Guan H. γ-Secretase inhibitor alleviates lipopolysaccharide-induced myocardial injury through regulating JAK2/STAT3 signaling. Environ Toxicol. 2024 Jan;39(1):135-147. doi: 10.1002/tox.23962. Epub 2023 Sep 6. PMID: 37671635. 10: Shen L, Zhang C, Cui K, Liang X, Zhu G. Low-Density Lipoprotein Contributes to Endometrial Carcinoma Cell Proliferation, Migration, and Invasion by Activating the JAK-STAT Signaling Pathway. Anal Cell Pathol (Amst). 2023 Oct 20;2023:4015167. doi: 10.1155/2023/4015167. PMID: 37900720; PMCID: PMC10611539. 11: Yi L, Hart JE, Straczkiewicz M, Karas M, Wilt GE, Hu CR, Librett R, Laden F, Chavarro JE, Onnela JP, James P. Measuring Environmental and Behavioral Drivers of Chronic Diseases Using Smartphone-Based Digital Phenotyping: Intensive Longitudinal Observational mHealth Substudy Embedded in 2 Prospective Cohorts of Adults. JMIR Public Health Surveill. 2024 Oct 11;10:e55170. doi: 10.2196/55170. PMID: 39392682; PMCID: PMC11512133.

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