Synonym
Melitracen; Melitracen; Melitracene
IUPAC/Chemical Name
1-Propanamine, 3-(10,10-dimethyl-9(10H)-anthracenylidene)-N,N-dimethyl- (9CI)
InChi Key
GWWLWDURRGNSRS-UHFFFAOYSA-N
InChi Code
InChI=1S/C21H25N/c1-21(2)19-13-7-5-10-17(19)16(12-9-15-22(3)4)18-11-6-8-14-20(18)21/h5-8,10-14H,9,15H2,1-4H3
SMILES Code
CN(C)CC/C=C1C2=C(C=CC=C2)C(C)(C)C3=CC=CC=C/13
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>2 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
Preparing Stock Solutions
The following data is based on the
product
molecular weight
291.44
Batch specific molecular weights may vary
from batch to batch
due to the degree of hydration, which will
affect the solvent
volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass |
1 mg |
5 mg |
10 mg |
| 1 mM |
1.15 mL |
5.76 mL |
11.51 mL |
| 5 mM |
0.23 mL |
1.15 mL |
2.3 mL |
| 10 mM |
0.12 mL |
0.58 mL |
1.15 mL |
| 50 mM |
0.02 mL |
0.12 mL |
0.23 mL |
1: Warnecke S, Rinnan Å, Allesø M, Engelsen SB. Fluorescence spectroscopy in process analytical technology (PAT): simultaneous quantification of two active pharmaceutical ingredients in a tablet formulation. Appl Spectrosc. 2015 Mar;69(3):323-31. doi: 10.1366/14-07470. PubMed PMID: 25760291.
2: Hashash JG, Abdul-Baki H, Azar C, Elhajj II, El Zahabi L, Chaar HF, Sharara AI. Clinical trial: a randomized controlled cross-over study of flupenthixol + melitracen in functional dyspepsia. Aliment Pharmacol Ther. 2008 Jun 1;27(11):1148-55. doi: 10.1111/j.1365-2036.2008.03677.x. Epub 2008 Mar 10. PubMed PMID: 18331614.
3: Walder A, Greil W, Baumann P. Purpura and ecchymosis under carbamazepine, chloral hydrate and melitracen-flupentixol. Eur J Dermatol. 2008 Jan-Feb;18(1):103-4. Epub 2007 Dec 18. PubMed PMID: 18086617.
4: Che J, Meng Q, Chen Z, San C, Hou Y, Cheng Y. Validation of a sensitive LC/MS/MS method for simultaneous quantitation of flupentixol and melitracene in human plasma. J Pharm Biomed Anal. 2007 Dec 21;45(5):785-92. Epub 2007 Jul 26. PubMed PMID: 17881181.
5: Yang CS, Young YH. Clinical investigation on hypotensive patients with vertigo. Eur Arch Otorhinolaryngol. 2006 Sep;263(9):804-8. Epub 2006 Jul 1. PubMed PMID: 16816934.
6: Giménez-Roldán S, Mateo D, Dobato JL. [Drug-induced and masked drug parkinsonism]. Rev Neurol. 1996 May;24(129):584-5. Spanish. PubMed PMID: 8681182.
7: Bin Yaacob H. Flupenthixol and Melitracen in the management of trigeminal neuralgia. Dent J Malays. 1985 Apr;8(2):37-8. PubMed PMID: 3917005.
8: Yaacob HB, Ab Hamid J. Use of antidepressants in aphthous ulceration--a clinical experience. Dent J Malays. 1985 Jan;8(1):33-8. PubMed PMID: 3916996.
9: Hertrich O. [Ataractic treatment in psychiatry and general medicine. Review of preparations. 9]. Fortschr Med. 1983 Oct 27;101(40):1828-30. German. PubMed PMID: 6642389.
10: Van Moffaert M, Dierick M, De Meulemeester F, Vereecken A. Treatment of depressive anxiety states associated with psychosomatic symptoms. A double-blind multicentre clinical study: mianserin versus melitracen-flupentixol. Acta Psychiatr Belg. 1983 Sep-Oct;83(5):525-39. PubMed PMID: 6670581.
11: Fuhrmann M, Hruby K, Gössinger H, Shroff D, Gassner B. [Clinical aspects and therapy of acute poisoning by the drug combination melitracen-flupenthixol (Deanxit)]. Wien Med Wochenschr. 1983 Jun 15;133(11):283-6. German. PubMed PMID: 6192595.
12: Shelkunov EL. [Effect of imipramine-like antidepressants on head shaking induced by 5-hydroxytryptophan in mice]. Biull Eksp Biol Med. 1978 Sep;86(9):304-6. Russian. PubMed PMID: 698373.
13: Karobath ME. Tricyclic antidepressive drugs and dopamine-sensitive adenylate cyclase from rat brain striatum. Eur J Pharmacol. 1975 Feb;30(2):159-63. PubMed PMID: 1126356.
14: Xhenseval B, Meyers C. [The tachythymoleptic action of melitracene: use in reactive depressions and in neurotic inhibitions (272 cases)]. Schweiz Rundsch Med Prax. 1972 Sep 5;61(36):1122-7. German. PubMed PMID: 4680959.
15: Xhenseval B, Meyers C. [Tachythymoanaleptic action of Melitracene: indication in reactive depressions and neurotic inhbitions (272 cases)]. Schweiz Rundsch Med Prax. 1972 Sep 5;61(36):1122-7. French. PubMed PMID: 4637732.
16: Greeff K, Wagner J. [Cardiodepressive and local anesthetic effect of thymoleptics. Comparative studies with imipramine, desipramine, amitriptyline, nortriptyline and melitracene]. Arzneimittelforschung. 1969 Oct;19(10):1662-4. German. PubMed PMID: 5395364.
17: Franczak W. [Treatment of enuresis in children with melitracene]. Pol Tyg Lek. 1969 Jan 27;24(4):145-6. Polish. PubMed PMID: 5776785.
18: Grof P, Jünemann HJ, Sang S. Comparative study of melitracene and amitriptyline in depressive patients. Act Nerv Super (Praha). 1967 Nov;9(4):385. PubMed PMID: 4889071.
19: Náhunek K, Svestka J, Misurec J. [Clinical experiences with melitracene (Trausabun). Effect of the photomyoclonic threshold]. Act Nerv Super (Praha). 1967 Nov;9(4):358-9. Czech. PubMed PMID: 4889062.
20: Vencovský E, Sedivec V, Peterová E, Baudis P. [Clinical experiences with melitracene treatment of depression]. Act Nerv Super (Praha). 1967 Nov;9(4):356-7. Czech. PubMed PMID: 4889060.
