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MedKoo Cat#: 591079 | Name: Isothipendyl hydrochloride
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Description:

WARNING: This product is for research use only, not for human or veterinary use.

Isothipendyl hydrochloride is a 1st generation H1 antagonist (antihistamine) and anticholinergic used as an antipruritic.

Chemical Structure

Isothipendyl hydrochloride
Isothipendyl hydrochloride
CAS#1225-60-1

Theoretical Analysis

MedKoo Cat#: 591079

Name: Isothipendyl hydrochloride

CAS#: 1225-60-1

Chemical Formula: C16H20ClN3S

Exact Mass: 321.1066

Molecular Weight: 321.87

Elemental Analysis: C, 59.71; H, 6.26; Cl, 11.01; N, 13.06; S, 9.96

Price and Availability

Size Price Availability Quantity
5mg USD 350.00 2 Weeks
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Related CAS #
No Data
Synonym
Isothipendyl hydrochloride; NSC 169186; NSC-169186; NSC169186
IUPAC/Chemical Name
10-(2-Dimethylaminopropyl)-10H-pyrido(3,2-b)(1,4)benzothiazine hydrochloride
InChi Key
RQHCFTORMXCNGP-UHFFFAOYSA-N
InChi Code
InChI=1S/C16H19N3S.ClH/c1-12(18(2)3)11-19-13-7-4-5-8-14(13)20-15-9-6-10-17-16(15)19;/h4-10,12H,11H2,1-3H3;1H
SMILES Code
CC(N(C)C)CN1C2=NC=CC=C2SC3=CC=CC=C13.[H]Cl
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>2 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 321.87 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Bibas N, Sartor V, Bulai Livideanu C, Bagheri H, Nougué J, Giordano-Labadie F, Maza A, Paul C, Chouini-Lalanne N, Marguery MC. Contact photoallergy to isothipendyl chlorhydrate. Dermatology. 2012;224(4):289-91. doi: 10.1159/000338024. Epub 2012 Jun 1. PubMed PMID: 22677929. 2: Melwanki MB, Seetharamappa J. Spectrophotometric studies on the investigation of chromium in environmental samples. Indian J Environ Health. 2003 Jan;45(1):25-8. PubMed PMID: 14723280. 3: Gowda BG, Seetharamappa J. Extractive spectrophotometric determination of fluoroquinolones and antiallergic drugs in pure and pharmaceutical formulations. Anal Sci. 2003 Mar;19(3):461-4. PubMed PMID: 12675360. 4: Melwanki MB, Seetharamappa J, Masti SP. Spectrophotometric determination of molybdenum(VI) using isothipendyl hydrochloride and pipazethate hydrochloride in alloy steels and soil samples. Anal Sci. 2001 Sep;17(9):1121-3. PubMed PMID: 11708072. 5: Moreau A, Dompmartin A, Dubreuil A, Leroy D. Phototoxic and photoprotective effects of topical isothipendyl. Photodermatol Photoimmunol Photomed. 1995 Apr;11(2):50-4. PubMed PMID: 8546983. 6: Kinnamon KE, Klayman DL, Poon BT, McCall JW, Dzimianski MT, Rowan SJ. Filariasis testing in a jird model: new drug leads from some old standbys. Am J Trop Med Hyg. 1994 Dec;51(6):791-6. PubMed PMID: 7810813. 7: Abdel-Hay MH, Elsayed MA, Barary MH, Hassan EM. Determination of isothipendyl or dimethothiazine with their sulphoxides using third- and fourth-derivatives spectroscopy on a diode-array spectrophotometer. J Pharm Belg. 1990 Jul-Aug;45(4):259-67. PubMed PMID: 2290121. 8: Maurer H, Pfleger K. Identification of phenothiazine antihistamines and their metabolites in urine. Arch Toxicol. 1988;62(2-3):185-91. PubMed PMID: 2904251. 9: Takashima Y, Tanaka S, Hosono S, Kawamata I, Murayama H. [Distribution of isothipendyl in O/W type creams and its release]. Yakugaku Zasshi. 1985 Feb;105(2):166-70. Japanese. PubMed PMID: 2861270. 10: Takashima A, Yoshikawa K. Contact allergy to isothipendyl. Contact Dermatitis. 1983 Sep;9(5):429-30. PubMed PMID: 6138212. 11: Bartsch W, Dietmann K, Nothdurft H. [Pharmacologic experience on the effects of antihistaminic isothipendyl hydrochloride combined with calcium gluconate]. Hospital (Rio J). 1969 Jan;75(1):187-99. Portuguese. PubMed PMID: 4387989. 12: INADA T, HONGO H, KITAYAMA T, MATSUO M. [THE USE OF ANDANTOL IN THE TREATMENT OF ALLERGIC DISEASES AT UROLOGICAL CLINIC]. Hinyokika Kiyo. 1964 Apr;10:226-33. Japanese. PubMed PMID: 14157559. 13: KATO H, YUGAWA S, MESHITSUKA T, IMAKUMI T, TAMURA T, OKI K, YAMAKAWA N. [Use of Andantol jelly in diseases of the ear, nose and throat]. Jibiinkoka. 1962 Jun;34:519-23. Japanese. PubMed PMID: 14454251. 14: OSAWA R, NAKAMURA M. [Experience in the use of Andantol jelly in the field of otorhinolaryngology]. Jibiinkoka. 1962 Feb;34:163-5. Japanese. PubMed PMID: 14482447. 15: DISSARD P. [Indications for suppositories with antihistaminic (Andantol) base in the treatment of hemorrhoidal anitis]. Lyon Med. 1962 Jan 28;94:181-6. French. PubMed PMID: 13886583. 16: TAKAHASI A. [Cure of several pruritic skin diseases with Andantol jelly]. Hifuka Kiyo. 1962 Jan;57:91-5. Japanese. PubMed PMID: 13919102. 17: OFUJI S, MATSUO T. [The clinical effect of Andantol jelly for pruritic skin diseases]. Hifuka Kiyo. 1961 Nov;56:361-2. Japanese. PubMed PMID: 14481215. 18: YANAGIHARA M, MATSUSAKA Y, HAMADA K. [The clinical effect of Andantol jelly]. Hifuka Kiyo. 1961 Nov;56:363-6. Japanese. PubMed PMID: 14008937. 19: SCHROEDER H, HUTSCHENREUTER K. [Experiences with andantol jelly in local therapy of superficial burns]. Med Welt. 1961 Sep 2;35:1788-90. German. PubMed PMID: 13748665. 20: UHR L, MILLER JG. An experimental study of the behavioral effects of isothipendyl hydrochloride (Theruhistin). Acta Allergol. 1961;16:141-50. PubMed PMID: 13779032.