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MedKoo Cat#: 581237 | Name: Chlorodifluoromethane

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Chlorodifluoromethane or difluoromonochloromethane is a hydrochlorofluorocarbon (HCFC). This colorless gas is better known as HCFC-22, or R-22. It is commonly used as a propellant and refrigerant. These applications are being phased out in developed countries due to the compound's ozone depletion potential (ODP) and high global warming potential (GWP), although global use of R-22 continues to increase because of high demand in developing countries. R-22 is a versatile intermediate in industrial organofluorine chemistry, e.g. as a precursor to tetrafluoroethylene. R-22 cylinders are colored light green.

Chemical Structure

Chlorodifluoromethane
Chlorodifluoromethane
CAS#75-45-6

Theoretical Analysis

MedKoo Cat#: 581237

Name: Chlorodifluoromethane

CAS#: 75-45-6

Chemical Formula: CHClF2

Exact Mass: 85.9735

Molecular Weight: 86.47

Elemental Analysis: C, 13.89; H, 1.17; Cl, 41.00; F, 43.94

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
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Related CAS #
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Synonym
Chlorodifluoromethane; Algeon 22; CCRIS 858; Freon 22; HSDB 143;
IUPAC/Chemical Name
chlorodifluoromethane
InChi Key
VOPWNXZWBYDODV-UHFFFAOYSA-N
InChi Code
InChI=1S/CHClF2/c2-1(3)4/h1H
SMILES Code
C(F)(F)Cl
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>2 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 86.47 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Keown D. Asphyxiation fatality exposure from chlorodifluoromethane. J Occup Environ Hyg. 2013;10(3):D40-1. doi: 10.1080/15459624.2012.755665. PubMed PMID: 23339474. 2: Ha JM, Kim D, Kim J, Ahn BS, Kim Y, Kang JW. High-temperature hydrodechlorination of ozone-depleting chlorodifluoromethane (HCFC-22) on supported Pd and Ni catalysts. J Environ Sci Health A Tox Hazard Subst Environ Eng. 2011;46(9):989-96. PubMed PMID: 21847789. 3: Chlorodifluoromethane. IARC Monogr Eval Carcinog Risks Hum. 1999;71 Pt 3:1339-43. PubMed PMID: 10476408. 4: Seymour MJ, Lucas MF. Evaluation of sampling and analytical methods for the determination of chlorodifluoromethane in air. Am Ind Hyg Assoc J. 1993 May;54(5):253-9. PubMed PMID: 8498360. 5: Fitzgerald RL, Fishel CE, Bush LL. Fatality due to recreational use of chlorodifluoromethane and chloropentafluoroethane. J Forensic Sci. 1993 Mar;38(2):477-83. PubMed PMID: 8455004. 6: Peter H, Filser JG, von Szentpály L, Wiegand HJ. Different pharmacokinetics of dichlorofluoromethane (CFC 21) and chlorodifluoromethane (CFC 22). Arch Toxicol. 1986 Apr;58(4):282-3. PubMed PMID: 3718233. 7: Kubota T, Miyata A. Acute inhalational exposure to chlorodifluoromethane (freon-22): a report of 43 cases. Clin Toxicol (Phila). 2005;43(4):305-8. PubMed PMID: 16035210. 8: Chlorodifluoromethane. IARC Monogr Eval Carcinog Risk Chem Hum. 1986;41:237-52. PubMed PMID: 3473028. 9: Wu BH, Xie YX, Pan QY. [Determination of chlorodifluoromethane in air of work places with gas chromatography]. Zhonghua Lao Dong Wei Sheng Zhi Ye Bing Za Zhi. 2009 May;27(5):288-9. Chinese. PubMed PMID: 19538845. 10: Sjögren B, Gunnare S, Sandler H. Inhalation of decomposed chlorodifluoromethane (freon-22) and myocardial infarction. Scand J Work Environ Health. 2002 Jun;28(3):205-7. PubMed PMID: 12109561. 11: Maltoni C, Lefemine G, Tovoli D, Perino G. Long-term carcinogenicity bioassays on three chlorofluorocarbons (trichlorofluoromethane, FC11; dichlorodifluoromethane, FC12; chlorodifluoromethane, FC22) administered by inhalation to Sprague-Dawley rats and Swiss mice. Ann N Y Acad Sci. 1988;534:261-82. PubMed PMID: 3389660. 12: Sun H, Chen L, Yue Z, Sun G, Ma W. [Measurement of chlorodifluoromethane(HCFC-22) in the atmosphere by using an O2-induced electron capture detector (ECD)]. Huan Jing Ke Xue. 2001 Jul;22(4):21-4. Chinese. PubMed PMID: 11569107. 13: Kintz P, Baccino E, Tracqui A, Mangin P. Headspace GC/MS testing for chlorodifluoromethane in two fatal cases. Forensic Sci Int. 1996 Sep 30;82(2):171-5. PubMed PMID: 8885375. 14: Woollen BH, Marsh JR, Mahler JD, Auton TR, Makepeace D, Cocker J, Blain PG. Human inhalation pharmacokinetics of chlorodifluoromethane (HCFC22). Int Arch Occup Environ Health. 1992;64(5):383-7. PubMed PMID: 1487335. 15: Nawrot E, Joñczyk A. Difluoromethyltrialkylammonium salts--their expeditious synthesis from chlorodifluoromethane and tertiary amines in the presence of concentrated aqueous sodium hydroxide. The catalytic process. J Org Chem. 2007 Dec 21;72(26):10258-60. Epub 2007 Nov 29. PubMed PMID: 18044916. 16: Fang X, Stohl A, Yokouchi Y, Kim J, Li S, Saito T, Park S, Hu J. Multiannual top-down estimate of HFC-23 emissions in East Asia. Environ Sci Technol. 2015 Apr 7;49(7):4345-53. doi: 10.1021/es505669j. Epub 2015 Mar 30. PubMed PMID: 25785483. 17: Zhang F, Xin C, Zhu B. [Simultaneous determination of three organic fluorides in workplace air by portable gas chromatography-mass spectrometer]. Zhonghua Lao Dong Wei Sheng Zhi Ye Bing Za Zhi. 2015 Jun;33(6):476-8. Chinese. PubMed PMID: 26653391. 18: Hartop PJ, Adams MG. Simulated consumer exposure to propellant HCFC 22 (chlorodifluoromethane) in aerosol personal products. Int J Cosmet Sci. 1989 Feb;11(1):27-34. doi: 10.1111/j.1467-2494.1989.tb00492.x. PubMed PMID: 19456932. 19: Abraham MH, Gil-Lostes J, Corr S, Acree WE Jr. Determination of partition coefficients of refrigerants by gas liquid chromatographic headspace analysis. J Chromatogr A. 2012 Nov 23;1265:144-8. doi: 10.1016/j.chroma.2012.09.085. Epub 2012 Oct 1. PubMed PMID: 23089519. 20: Wegert A, Hein M, Reinke H, Hoffmann N, Miethchen R. Chlorodifluoromethyl-substituted monosaccharide derivatives--radical activation of the carbon-chlorine-bond. Carbohydr Res. 2006 Nov 27;341(16):2641-52. Epub 2006 Sep 20. PubMed PMID: 16989789.