Adam I-123 | CAS# 305352-16-3 | radiopharmaceutical

MedKoo Cat#: 591069 | Name: Adam I-123

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Adam I-123 is a radiopharmaceutical containing the serotonin transporter (SERT) ligand ADAM [2-((2-((dimethylamino)methyl)phenyl)thio)-5-iodophenylamine] labeled with the radioisotope iodine I 123, with SERT-binding and radioisotope activities. SERT is a monamine transporter protein found in the membranes of neurons and platelets; in neurons it transports the neurotransmitter serotonin from synaptic spaces into presynaptic neurons, terminating serotonin's function.

Chemical Structure

Adam I-123

CAS#305352-16-3

Theoretical Analysis

MedKoo Cat#: 591069

Name: Adam I-123

CAS#: 305352-16-3

Chemical Formula: C15H17123IN2S

Exact Mass: 380.0168

Molecular Weight: 380.28

Elemental Analysis: C, 47.38; H, 4.51; I, 32.32; N, 7.37; S, 8.43

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.

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Related CAS #

No Data

Synonym

Adam I-123; Adam I 123; Adam I123;

IUPAC/Chemical Name

Benzenemethanamine, 2-((2-amino-4-(iodo-123i)phenyl)thio)-N,N-dimethyl-

InChi Key

KPKLDBBNSFWOFA-KIWWSDKQSA-N

InChi Code

InChI=1S/C15H17IN2S/c1-18(2)10-11-5-3-4-6-14(11)19-15-8-7-12(16)9-13(15)17/h3-9H,10,17H2,1-2H3/i16-4

SMILES Code

CN(C)CC1=CC=CC=C1SC2=CC=C([123I])C=C2N

Appearance

Solid powder

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

Soluble in DMSO

Shelf Life

>2 years if stored properly

Drug Formulation

This drug may be formulated in DMSO

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.9001

More Info

Instruction

View handling instruction

Preparing Stock Solutions

The following data is based on the product molecular weight 380.28 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

1: Wu CH, Chang CS, Yang YK, Shen LH, Yao WJ. Comparison of brain serotonin transporter using [I-123]-ADAM between obese and non-obese young adults without an eating disorder. PLoS One. 2017 Feb 9;12(2):e0170886. doi: 10.1371/journal.pone.0170886. eCollection 2017. PubMed PMID: 28182708; PubMed Central PMCID: PMC5300236. 2: Huang CI, Yao WJ, Sun YN. New methods for registering long-time I-123 ADAM SPECT image sequences to magnetic resonance images. Nucl Med Commun. 2010 Aug;31(8):734-40. doi: 10.1097/MNM.0b013e32833b7534. PubMed PMID: 20505552. 3: Koch W, Schaaff N, Pöpperl G, Mulert C, Juckel G, Reicherzer M, Ehmer-von Geiso C, Möller HJ, Hegerl U, Tatsch K, Pogarell O. [I-123] ADAM and SPECT in patients with borderline personality disorder and healthy control subjects. J Psychiatry Neurosci. 2007 Jul;32(4):234-40. PubMed PMID: 17653291; PubMed Central PMCID: PMC1911193. 4: Choi SR, Hou C, Oya S, Mu M, Kung MP, Siciliano M, Acton PD, Kung HF. Selective in vitro and in vivo binding of [(125)I]ADAM to serotonin transporters in rat brain. Synapse. 2000 Dec 15;38(4):403-12. PubMed PMID: 11044887.