Synonym
NSC-65381; NSC65381; NSC 65381; Cellocidin; NSC 38643; NSC38643; NSC-38643; Lenamycin; Aquamycin; Acetylene dicarboxamide;
IUPAC/Chemical Name
But-2-ynediamide
InChi Key
JBTGHKUTYAMZEZ-UHFFFAOYSA-N
InChi Code
InChI=1S/C4H4N2O2/c5-3(7)1-2-4(6)8/h(H2,5,7)(H2,6,8)
SMILES Code
O=C(N)C#CC(N)=O
Purity
>95% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>2 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
Preparing Stock Solutions
The following data is based on the
product
molecular weight
112.08
Batch specific molecular weights may vary
from batch to batch
due to the degree of hydration, which will
affect the solvent
volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass |
1 mg |
5 mg |
10 mg |
| 1 mM |
1.15 mL |
5.76 mL |
11.51 mL |
| 5 mM |
0.23 mL |
1.15 mL |
2.3 mL |
| 10 mM |
0.12 mL |
0.58 mL |
1.15 mL |
| 50 mM |
0.02 mL |
0.12 mL |
0.23 mL |
1: SUZUKI S, NAKAMURA G, OKUMA K, TOMIYAMA Y. Cellocidin, a new antibiotic. J Antibiot (Tokyo). 1958 May;11(3):81-3. PMID: 13563326.
2: SUZUKI S, OKUMA K. The structure of cellocidin. J Antibiot (Tokyo). 1958 May;11(3):84-6. PMID: 13563327.
3: Jakhmola S, Hazarika Z, Jha AN, Jha HC. In silico analysis of antiviral phytochemicals efficacy against Epstein-Barr virus glycoprotein H. J Biomol Struct Dyn. 2022 Aug;40(12):5372-5385. doi: 10.1080/07391102.2020.1871074. Epub 2021 Jan 13. PMID: 33438528.
4: Yoneyama K, Sekido S, Misato T. Antagonistic mechanism of sulfhydryl compounds on cellocidin activity. J Antibiot (Tokyo). 1978 Oct;31(10):1065-6. doi: 10.7164/antibiotics.31.1065. PMID: 711614.
5: Otoguro K, Ishiyama A, Namatame M, Nishihara A, Furusawa T, Masuma R, Shiomi K, Takahashi Y, Yamada H, Omura S. Selective and potent in vitro antitrypanosomal activities of ten microbial metabolites. J Antibiot (Tokyo). 2008 Jun;61(6):372-8. doi: 10.1038/ja.2008.52. PMID: 18667785.
6: Jones ER, Keeping JW, Pellatt MG, Thaller V. Natural acetylenes. 38. Biosyntheses of acetylenedicarboxamide (cellocidin) in Streptomyces SF-536 cultures. J Chem Soc Perkin 1. 1973;2:148-50. doi: 10.1039/p19730000148. PMID: 4736298.
