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MedKoo Cat#: 591064 | Name: Thiamethoxam
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Description:

WARNING: This product is for research use only, not for human or veterinary use.

Thiamethoxam is a systemic insecticide in the class of neonicotinoids. It has a broad spectrum of activity against many types of insects.

Chemical Structure

Thiamethoxam
Thiamethoxam
CAS#153719-23-4

Theoretical Analysis

MedKoo Cat#: 591064

Name: Thiamethoxam

CAS#: 153719-23-4

Chemical Formula: C8H10ClN5O3S

Exact Mass: 291.0193

Molecular Weight: 291.71

Elemental Analysis: C, 32.94; H, 3.46; Cl, 12.15; N, 24.01; O, 16.45; S, 10.99

Price and Availability

Size Price Availability Quantity
100mg USD 250.00 2 weeks
500mg USD 550.00 2 Weeks
1g USD 850.00 2 Weeks
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Related CAS #
No Data
Synonym
Adage; Adage 5FS
IUPAC/Chemical Name
3-(2-Chloro-thiazol-5-ylmethyl)-5-methyl(1,3,5)oxadiazinan-4-ylidene-N-nitroamine
InChi Key
NWWZPOKUUAIXIW-DHZHZOJOSA-N
InChi Code
InChI=1S/C8H10ClN5O3S/c1-12-4-17-5-13(8(12)11-14(15)16)3-6-2-10-7(9)18-6/h2H,3-5H2,1H3/b11-8+
SMILES Code
O=[N+](/N=C1N(CC2=CN=C(Cl)S2)COCN/1C)[O-]
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>2 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 291.71 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Zhang Q, Wang X, Li Z, Jin H, Lu Z, Yu C, Huang YF, Zhao M. Simultaneous determination of nine neonicotinoids in human urine using isotope-dilution ultra-performance liquid chromatography-tandem mass spectrometry. Environ Pollut. 2018 May 14;240:647-652. doi: 10.1016/j.envpol.2018.04.144. [Epub ahead of print] PubMed PMID: 29772515. 2: Kachangoon R, Vichapong J, Burakham R, Santaladchaiyakit Y, Srijaranai S. Ultrasonically Modified Amended-Cloud Point Extraction for Simultaneous Pre-Concentration of Neonicotinoid Insecticide Residues. Molecules. 2018 May 12;23(5). pii: E1165. doi: 10.3390/molecules23051165. PubMed PMID: 29757232. 3: Song S, Zhang C, Chen Z, He F, Wei J, Tan H, Li X. Simultaneous determination of neonicotinoid insecticides and insect growth regulators residues in honey using LC-MS/MS with anion exchanger-disposable pipette extraction. J Chromatogr A. 2018 May 3. pii: S0021-9673(18)30561-2. doi: 10.1016/j.chroma.2018.05.003. [Epub ahead of print] PubMed PMID: 29735281. 4: Focks A, Belgers D, Boerwinkel MC, Buijse L, Roessink I, Van den Brink PJ. Calibration and validation of toxicokinetic-toxicodynamic models for three neonicotinoids and some aquatic macroinvertebrates. Ecotoxicology. 2018 May 1. doi: 10.1007/s10646-018-1940-6. [Epub ahead of print] PubMed PMID: 29717389. 5: Marina CF, Bond JG, Muñoz J, Valle J, Quiroz-Martínez H, Torres-Monzón JA, Williams T. Efficacy of larvicides for the control of dengue, Zika, and chikungunya vectors in an urban cemetery in southern Mexico. Parasitol Res. 2018 Jun;117(6):1941-1952. doi: 10.1007/s00436-018-5891-x. Epub 2018 Apr 30. PubMed PMID: 29713901. 6: Challis JK, Cuscito LD, Joudan S, Luong KH, Knapp CW, Hanson ML, Wong CS. Inputs, source apportionment, and transboundary transport of pesticides and other polar organic contaminants along the lower Red River, Manitoba, Canada. Sci Total Environ. 2018 Apr 20;635:803-816. doi: 10.1016/j.scitotenv.2018.04.128. [Epub ahead of print] PubMed PMID: 29710604. 7: Baldissera MD, Souza CF, Seben D, Sippert LR, Salbego J, Marchesan E, Zanella R, Baldisserotto B, Golombieski JI. Gill bioenergetics dysfunction and oxidative damage induced by thiamethoxam exposure as relevant toxicological mechanisms in freshwater silver catfish Rhamdia quelen. Sci Total Environ. 2018 Apr 27;636:420-426. doi: 10.1016/j.scitotenv.2018.04.292. [Epub ahead of print] PubMed PMID: 29709859. 8: MacDonald AM, Jardine CM, Thomas PJ, Nemeth NM. Neonicotinoid detection in wild turkeys (Meleagris gallopavo silvestris) in Ontario, Canada. Environ Sci Pollut Res Int. 2018 Apr 27. doi: 10.1007/s11356-018-2093-0. [Epub ahead of print] PubMed PMID: 29704179. 9: Langdon KW, Schumann R, Stelinski LL, Rogers ME. Spatial and Temporal Distribution of Soil-Applied Neonicotinoids in Citrus Tree Foliage. J Econ Entomol. 2018 Apr 23. doi: 10.1093/jee/toy114. [Epub ahead of print] PubMed PMID: 29688422. 10: Suganthi A, Nikita SA, Kousika J, Bhuvaneswari K, Sridharan S. Determination of thiamethoxam residues in banana stem and fruit through LC-MS/MS. Environ Monit Assess. 2018 Apr 18;190(5):293. doi: 10.1007/s10661-018-6655-x. PubMed PMID: 29671070. 11: Pan Y, Tian F, Wei X, Wu Y, Gao X, Xi J, Shang Q. Thiamethoxam Resistance in Aphis gossypii Glover Relies on Multiple UDP-Glucuronosyltransferases. Front Physiol. 2018 Apr 3;9:322. doi: 10.3389/fphys.2018.00322. eCollection 2018. PubMed PMID: 29670540; PubMed Central PMCID: PMC5893893. 12: Moyakao K, Santaladchaiyakit Y, Srijaranai S, Vichapong J. Preconcentration of Trace Neonicotinoid Insecticide Residues Using Vortex-Assisted Dispersive Micro Solid-Phase Extraction with Montmorillonite as an Efficient Sorbent. Molecules. 2018 Apr 11;23(4). pii: E883. doi: 10.3390/molecules23040883. PubMed PMID: 29641473. 13: Baldissera MD, Souza CF, Golombieski JI, Seben D, Sippert LR, Salbego J, Zanella R, Baldisserotto B. Thiamethoxam induced hepatic energy changes in silver catfish via impairment of the phosphoryl transfer network pathway: Toxicological effects on energetics homeostasis. Environ Toxicol Pharmacol. 2018 Apr 3;60:1-4. doi: 10.1016/j.etap.2018.04.002. [Epub ahead of print] PubMed PMID: 29631152. 14: de Lima E Silva C, Mariette J, Verweij RA, van Gestel CAM. Assessing the toxicity of thiamethoxam, in natural LUFA 2.2 soil, through three generations of Folsomia candida. Ecotoxicology. 2018 Apr 3. doi: 10.1007/s10646-018-1922-8. [Epub ahead of print] PubMed PMID: 29616379. 15: Hernando MD, Gámiz V, Gil-Lebrero S, Rodríguez I, García-Valcárcel AI, Cutillas V, Fernández-Alba AR, Flores JM. Viability of honeybee colonies exposed to sunflowers grown from seeds treated with the neonicotinoids thiamethoxam and clothianidin. Chemosphere. 2018 Jul;202:609-617. doi: 10.1016/j.chemosphere.2018.03.115. Epub 2018 Mar 19. PubMed PMID: 29597178. 16: Şenyildiz M, Kilinc A, Ozden S. Investigation of the genotoxic and cytotoxic effects of widely used neonicotinoid insecticides in HepG2 and SH-SY5Y cells. Toxicol Ind Health. 2018 Jun;34(6):375-383. doi: 10.1177/0748233718762609. Epub 2018 Mar 28. PubMed PMID: 29591886. 17: Sultana T, Murray C, Kleywegt S, Metcalfe CD. Neonicotinoid pesticides in drinking water in agricultural regions of southern Ontario, Canada. Chemosphere. 2018 Jul;202:506-513. doi: 10.1016/j.chemosphere.2018.02.108. Epub 2018 Mar 21. PubMed PMID: 29587231. 18: Manjon C, Troczka BJ, Zaworra M, Beadle K, Randall E, Hertlein G, Singh KS, Zimmer CT, Homem RA, Lueke B, Reid R, Kor L, Kohler M, Benting J, Williamson MS, Davies TGE, Field LM, Bass C, Nauen R. Unravelling the Molecular Determinants of Bee Sensitivity to Neonicotinoid Insecticides. Curr Biol. 2018 Apr 2;28(7):1137-1143.e5. doi: 10.1016/j.cub.2018.02.045. Epub 2018 Mar 22. PubMed PMID: 29576476; PubMed Central PMCID: PMC5887109. 19: Maloney EM, Morrissey CA, Headley JV, Peru KM, Liber K. Can chronic exposure to imidacloprid, clothianidin, and thiamethoxam mixtures exert greater than additive toxicity in Chironomus dilutus? Ecotoxicol Environ Saf. 2018 Jul 30;156:354-365. doi: 10.1016/j.ecoenv.2018.03.003. Epub 2018 Mar 21. PubMed PMID: 29573726. 20: Kumar N, Narayanan N, Gupta S. Application of magnetic molecularly imprinted polymers for extraction of imidacloprid from eggplant and honey. Food Chem. 2018 Jul 30;255:81-88. doi: 10.1016/j.foodchem.2018.02.061. Epub 2018 Feb 12. PubMed PMID: 29571502.