Synonym
Adafenoxate; Adafenoxato; Adafenoxato
IUPAC/Chemical Name
2-(1-Adamantylamino)ethyl (p-chlorophenoxy)acetate
InChi Key
PLSMXIQMWYSHIV-UHFFFAOYSA-N
InChi Code
InChI=1S/C20H26ClNO3/c21-17-1-3-18(4-2-17)25-13-19(23)24-6-5-22-20-10-14-7-15(11-20)9-16(8-14)12-20/h1-4,14-16,22H,5-13H2
SMILES Code
O=C(OCCNC12CC3CC(C2)CC(C3)C1)COC4=CC=C(Cl)C=C4
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>2 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
Preparing Stock Solutions
The following data is based on the
product
molecular weight
0.00
Batch specific molecular weights may vary
from batch to batch
due to the degree of hydration, which will
affect the solvent
volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass |
1 mg |
5 mg |
10 mg |
| 1 mM |
1.15 mL |
5.76 mL |
11.51 mL |
| 5 mM |
0.23 mL |
1.15 mL |
2.3 mL |
| 10 mM |
0.12 mL |
0.58 mL |
1.15 mL |
| 50 mM |
0.02 mL |
0.12 mL |
0.23 mL |
1: Stancheva SL, Alova LG. Biogenic monoamine uptake by rat brain synaptosomes during aging. Effects of nootropic drugs. Gen Pharmacol. 1994 Sep;25(5):981-7. PubMed PMID: 7835648.
2: Hadjiivanova CI, Stancheva SL. In vitro and in vivo effect of the nootropic agent adafenoxate on the 5-HT1 sites in different rat brain structures. Gen Pharmacol. 1994 Sep;25(5):977-9. PubMed PMID: 7835647.
3: Genkova-Papazova MG, Stancheva SL, Alova LG, Lazarova-Bakarova MB. Adafenoxate abolishes the amnesia induced by neonatal 6-hydroxydopamine treatment in rats. Methods Find Exp Clin Pharmacol. 1993 Jun;15(5):267-71. PubMed PMID: 8412411.
4: Petkov VD, Markovska VL, Petkov VV. Effects of serotoninergic receptor antagonists and their combination with scopolamine on memory. Acta Physiol Pharmacol Bulg. 1991;17(1):21-8. PubMed PMID: 1815467.
5: Lazarova-Bakarova MB, Petkova BP, Todorov IK, Petkov VD. Memory impairment induced by combined disturbance of noradrenergic and dopaminergic neurotransmissions: effects of nootropic drugs. Acta Physiol Pharmacol Bulg. 1991;17(1):29-34. PubMed PMID: 1667717.
6: Stancheva SL, Alova LG. Age-related changes of cyclic AMP phosphodiesterase activity in rat brain regions and a new phosphodiesterase inhibitor--nootropic agent adafenoxate. Gen Pharmacol. 1991;22(5):955-8. PubMed PMID: 1662175.
7: Petkov VD, Mosharrof AH, Petkov VV, Kehayov RA. Age-related differences in memory and in the memory effects of nootropic drugs. Acta Physiol Pharmacol Bulg. 1990;16(2):28-36. PubMed PMID: 2281798.
8: Petkov VD, Stancheva SL, Tocuschieva L, Petkov VV. Changes in brain biogenic monoamines induced by the nootropic drugs adafenoxate and meclofenoxate and by citicholine (experiments on rats). Gen Pharmacol. 1990;21(1):71-5. PubMed PMID: 2105261.
9: Petkov VD, Mosharrof AH. Memory effects of the new derivative of the p-chlorophenoxyacetic acid adafenoxate compared to the effects of some cognition-enhancing drugs in rats. Arzneimittelforschung. 1989 Sep;39(9):1133-6. PubMed PMID: 2511850.
10: Stancheva S, Kunova P. Effect of adafenoxate on different rat brain structures monoamine oxidase activity in vitro. Comp Biochem Physiol C. 1989;94(1):41-4. PubMed PMID: 2576744.
11: Todorov S, Petkov V. Comparative studies on the effects of the nootropic drug adafenoxate and of the cerebral vasodilator flunarizine on arterial smooth muscles. Acta Physiol Pharmacol Bulg. 1988;14(3):10-6. PubMed PMID: 3146886.
12: Petkov VD, Mosharrof AH, Petkov VV. Comparative studies on the effects of the nootropic drugs adafenoxate, meclofenoxate and piracetam, and of citicholine on scopolamine-impaired memory, exploratory behavior and physical capabilities (experiments on rats and mice). Acta Physiol Pharmacol Bulg. 1988;14(1):3-13. PubMed PMID: 3136617.
13: Stancheva SL, Petkov VD, Petkov VV. Effects of the nootropic agents adafenoxate and meclofenoxate on brain biogenic monoamines in aged rats. Acta Physiol Pharmacol Bulg. 1988;14(1):14-21. PubMed PMID: 3136616.
14: Petkov VD, Kehayov R. Individually-determined differences in the effects of psychotropic drugs on memory (experiments on rats). Acta Physiol Pharmacol Bulg. 1987;13(3):30-6. PubMed PMID: 3125719.
15: Petkov VD, Popova JS. Effects of the nootropic agents adafenoxate, meclofenoxate and the acetylcholine precursor citicholine on the brain muscarinic receptors (experiments on rats). Acta Physiol Pharmacol Bulg. 1987;13(2):3-10. PubMed PMID: 3118641.
16: Petkov VD, Getova D, Mosharrof AH. A study of nootropic drugs for anti-anxiety action. Acta Physiol Pharmacol Bulg. 1987;13(4):25-30. PubMed PMID: 2896427.
