Synonym
SMBA2; SMBA-2; SMBA 2; NSC-4436; NSC 4436; NSC4436;
IUPAC/Chemical Name
1,3,6,8-Tetraazatricyclo[6.2.1.13,6]dodecane
InChi Key
ZBFHXDNNFOOFLY-UHFFFAOYSA-N
InChi Code
InChI=1S/C8H16N4/c1-2-10-5-9(1)7-11-3-4-12(6-11)8-10/h1-8H2
SMILES Code
N1(C2)CN3CCN(C3)CN2CC1
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>2 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
Preparing Stock Solutions
The following data is based on the
product
molecular weight
168.24
Batch specific molecular weights may vary
from batch to batch
due to the degree of hydration, which will
affect the solvent
volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass |
1 mg |
5 mg |
10 mg |
| 1 mM |
1.15 mL |
5.76 mL |
11.51 mL |
| 5 mM |
0.23 mL |
1.15 mL |
2.3 mL |
| 10 mM |
0.12 mL |
0.58 mL |
1.15 mL |
| 50 mM |
0.02 mL |
0.12 mL |
0.23 mL |
1: Xin M, Li R, Xie M, Park D, Owonikoko TK, Sica GL, Corsino PE, Zhou J, Ding C, White MA, Magis AT, Ramalingam SS, Curran WJ, Khuri FR, Deng X. Small-molecule Bax agonists for cancer therapy. Nat Commun. 2014 Sep 17;5:4935. doi: 10.1038/ncomms5935. PubMed PMID: 25230299; PubMed Central PMCID: PMC4172359.
2: Yamanaka K, Ogura T, Koonin EV, Niki H, Hiraga S. Multicopy suppressors, mssA and mssB, of an smbA mutation of Escherichia coli. Mol Gen Genet. 1994 Apr;243(1):9-16. PubMed PMID: 8190075.
3: Yamanaka K, Ogura T, Murata K, Suzaki T, Niki H, Hiraga S. Characterization of translucent segments observed in an smbA mutant of Escherichia coli. FEMS Microbiol Lett. 1994 Feb 1;116(1):61-6. PubMed PMID: 8132156.
