DAT 582 | CAS# 141034-42-6

MedKoo Cat#: 591054 | Name: DAT 582

Description:

WARNING: This product is for research use only, not for human or veterinary use.

DAT 582 is a novel serotonin3 receptor antagonist, is a potent and long-lasting antiemetic agent

Chemical Structure

DAT 582

CAS#141034-42-6

Theoretical Analysis

MedKoo Cat#: 591054

Name: DAT 582

CAS#: 141034-42-6

Chemical Formula: C22H29Cl2N5O

Exact Mass: 449.1749

Molecular Weight: 450.41

Elemental Analysis: C, 58.67; H, 6.49; Cl, 15.74; N, 15.55; O, 3.55

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.

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Related CAS #

No Data

Synonym

DAT 582; DAT582; DAT-582

IUPAC/Chemical Name

1H-Indazole-3-carboxamide, N-(hexahydro-1-methyl-4-((3-methylphenyl)methyl)-1H-1,4-diazepin-6-yl)-, dihydrochloride, (R)-

InChi Key

BDHAPQXDDJQQBI-JPKZNVRTSA-N

InChi Code

InChI=1S/C22H27N5O.2ClH/c1-16-6-5-7-17(12-16)13-27-11-10-26(2)14-18(15-27)23-22(28)21-19-8-3-4-9-20(19)24-25-21;;/h3-9,12,18H,10-11,13-15H2,1-2H3,(H,23,28)(H,24,25);2*1H/t18-;;/m1../s1

SMILES Code

O=C(C1=NNC2=C1C=CC=C2)N[C@H]3CN(CC4=CC=CC(C)=C4)CCN(C)C3.[H]Cl.[H]Cl

Appearance

Solid powder

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

Soluble in DMSO

Shelf Life

>2 years if stored properly

Drug Formulation

This drug may be formulated in DMSO

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.9001

More Info

Instruction

View handling instruction

Preparing Stock Solutions

The following data is based on the product molecular weight 450.41 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

1: Meyer O, Hoffmann T, Aslan T, Ahrens N, Kiesewetter H, Salama A. Diclofenac-induced antibodies against RBCs and platelets: two case reports and a concise review. Transfusion. 2003 Mar;43(3):345-9. Review. PubMed PMID: 12675720. 2: Kato S, Fujiwara I, Yoshida N. Nitrogen-containing heteroalicycles with serotonin receptor binding affinity: development of gastroprokinetic and antiemetic agents. Med Res Rev. 1999 Jan;19(1):25-73. Review. PubMed PMID: 9918193. 3: Newberry NR, Sprosen TS, Watkins CJ, Leslie RA, Grahame-Smith DG. AS-5370 potently antagonizes 5-HT3 receptor-mediated responses on NG108-15 cells and on the rat vagus. Eur J Pharmacol. 1992 Aug 14;219(1):135-40. PubMed PMID: 1397040. 4: Yoshida N, Omoya H, Kato S, Ito T. 5-HT3 receptor antagonist effects of DAT-582, (R) enantiomer of AS-5370. Eur J Pharmacol. 1992 Jun 17;216(3):435-40. PubMed PMID: 1425931. 5: Yoshida N, Omoya H, Ito T. DAT-582, a novel serotonin3 receptor antagonist, is a potent and long-lasting antiemetic agent in the ferret and dog. J Pharmacol Exp Ther. 1992 Mar;260(3):1159-65. PubMed PMID: 1532032.