t-Boc-aminooxy-PEG6-propargyl is a PEG derivative containing a propargyl group and t-Boc-aminooxy group. The propargyl group can be reacted with azide-bearing compounds or biomolecules via copper catalyzed azide-alkyne Click Chemistry to yield a stable triazole linkage. The protected aminooxy can be deprotected under mild acidic conditions and then can be reacted with an aldehyde or ketone group to form a stable oxime linkage. PEG Linkers my be useful in the development of antibody drug conjugates.
MedKoo Cat#: 571739
Name: t-Boc-aminooxy-PEG6-propargyl
CAS#: 2093152-83-9
Chemical Formula: C20H37NO9
Exact Mass: 435.2468
Molecular Weight: 435.51
Elemental Analysis: C, 55.16; H, 8.56; N, 3.22; O, 33.06
The following data is based on the product molecular weight 435.51 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
