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MedKoo Cat#: 596078 | Name: Coenzyme Q12

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Ubiquinone, also known as coenzyme Q10 (CoQ10), is a lipid-soluble benzoquinone compound that functions as an essential electron carrier in the mitochondrial electron transport chain. It shuttles electrons between Complexes I/II and Complex III, facilitating ATP production through oxidative phosphorylation. Structurally, ubiquinone consists of a quinone head group and a hydrophobic isoprenoid tail, which anchors it within the inner mitochondrial membrane.

Chemical Structure

Coenzyme Q12
CAS#24663-36-3

Theoretical Analysis

MedKoo Cat#: 596078

Name: Coenzyme Q12

CAS#: 24663-36-3

Chemical Formula: C69H106O4

Exact Mass: 998.8091

Molecular Weight: 999.60

Elemental Analysis: C, 82.91; H, 10.69; O, 6.40

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
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Related CAS #
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Synonym
Coenzyme Q12; trans-Coenzyme Q12; J93.222A; Ubiquinone 12; Ubiquinone Q-12; Coenzyme Q-12; Coenzyme Q 12;
IUPAC/Chemical Name
2-((2E,6E,10E,14E,18E,22E,26E,30E,34E,38E,42E)-3,7,11,15,19,23,27,31,35,39,43,47-dodecamethyloctatetraconta-2,6,10,14,18,22,26,30,34,38,42,46-dodecaen-1-yl)-5,6-dimethoxy-3-methylcyclohexa-2,5-diene-1,4-dione
InChi Key
NWAKMJSLSDJISV-JVLSEPFISA-N
InChi Code
InChI=1S/C69H106O4/c1-52(2)28-17-29-53(3)30-18-31-54(4)32-19-33-55(5)34-20-35-56(6)36-21-37-57(7)38-22-39-58(8)40-23-41-59(9)42-24-43-60(10)44-25-45-61(11)46-26-47-62(12)48-27-49-63(13)50-51-65-64(14)66(70)68(72-15)69(73-16)67(65)71/h28,30,32,34,36,38,40,42,44,46,48,50H,17-27,29,31,33,35,37,39,41,43,45,47,49,51H2,1-16H3/b53-30+,54-32+,55-34+,56-36+,57-38+,58-40+,59-42+,60-44+,61-46+,62-48+,63-50+
SMILES Code
O=C1C(C/C=C(C)/CC/C=C(C)/CC/C=C(C)/CC/C=C(C)/CC/C=C(C)/CC/C=C(C)/CC/C=C(C)/CC/C=C(C)/CC/C=C(C)/CC/C=C(C)/CC/C=C(C)/CC/C=C(C)\C)=C(C)C(C(OC)=C1OC)=O
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>2 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 999.60 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
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Hyperbranched Macromonomer-Based Gelation of Hyaluronic Acid for Efficient Liposome Encapsulation and Improved Transdermal Delivery. Macromol Rapid Commun. 2025 May 13:e2500310. doi: 10.1002/marc.202500310. Epub ahead of print. PMID: 40356406. 5: Yuan ZJ, Xiao Y, Liu Z, Zhang AQ, Li B, Gao SX. [Effect of total secondary ginsenosides on apoptosis and energy metabolism of H9c2 cells under hypoxia based on mitochondrial biogenesis]. Zhongguo Zhong Yao Za Zhi. 2025 Mar;50(5):1255-1266. Chinese. doi: 10.19540/j.cnki.cjcmm.20240919.405. PMID: 40350909. 6: Zeng J, Cheng J, Zhu L, Tang S. The effects of various nutritional supplements in patients with chronic obstructive pulmonary disease: a network meta-analysis. BMC Pulm Med. 2025 May 8;25(1):220. doi: 10.1186/s12890-025-03667-0. PMID: 40340688; PMCID: PMC12060334. 7: Stutts J, Clatterbuck K, Duckworth C, Pemberton T, Elkins A, Patra P, Stoecker W, Geria N, Nosoudi N. 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Antioxidants (Basel). 2025 Mar 27;14(4):396. doi: 10.3390/antiox14040396. PMID: 40298667; PMCID: PMC12024093. 11: Quintiero V, Crisafulli O, Diotti D, Tupler R, Negro M, Lavaselli E, D'Antona G. State-of-the-Art and Future Challenges for Nutritional Interventions in Facioscapulohumeral Dystrophy: A Narrative Review. Nutrients. 2025 Mar 17;17(6):1056. doi: 10.3390/nu17061056. PMID: 40292463; PMCID: PMC11944979. 12: Chen X, Chen B, Li Z, Ma L, Zhu Q, Liu C, He H, Zhang Z, Zhou C, Liu G, Zhou Y, Deng S, Guo S, Chen Y. The Extract of Camellia Seed Cake Alleviates Metabolic Dysfunction-Associated Steatotic Liver Disease (MASLD) in Mice by Promoting Coenzyme Q Synthesis. Nutrients. 2025 Mar 15;17(6):1032. doi: 10.3390/nu17061032. PMID: 40292441; PMCID: PMC11944731. 13: Fratter A, Colletti A, Cravotto G, Pellizzato M, Papetti A, Pellicorio V, Bolego C, Simiele M, D'Avolio A, Cignarella A. Novel Lipid-Based Formulation to Enhance Coenzyme Q10 Bioavailability: Preclinical Assessment and Phase 1 Pharmacokinetic Trial. Pharmaceutics. 2025 Mar 25;17(4):414. doi: 10.3390/pharmaceutics17040414. PMID: 40284410; PMCID: PMC12030634. 14: Mantle D, Hargreaves I. Coenzyme Q10 and the Blood-Brain Barrier: An Overview. J Clin Med. 2025 Apr 16;14(8):2748. doi: 10.3390/jcm14082748. PMID: 40283578; PMCID: PMC12027549. 15: Nahed RA, Hussein A, Cottet-Rousselle C, Vogelsang A, Aulicino F, Berger I, Blatt T, Weise JM, Schlattner U. Coenzyme Q10 protects keratinocytes against oxidation-induced energy stress as revealed by spatiotemporal analysis of cell energetics. Sci Rep. 2025 Apr 25;15(1):14501. doi: 10.1038/s41598-025-98793-4. PMID: 40281131; PMCID: PMC12032005. 16: Sharma H, Binte Ibrahim S, Al Noman A, Zohora UFT, Shifa FA, Siddika S, Tasneem S, Al Azad M, Pathak R. The Potential of Coenzyme Q10 in Alzheimer's Disease: Reducing IL-17 Induced Inflammation and Oxidative Stress for Neuroprotection. Curr Drug Res Rev. 2025 Apr 24. doi: 10.2174/0125899775373406250411104442. Epub ahead of print. PMID: 40277120. 17: Hou J, Chang Q. Letrozole versus coenzyme Q10 plus Clomiphene citrate for women with Polycystic Ovarian Syndrome: An efficacy and safety analysis. Biomol Biomed. 2025 Apr 23. doi: 10.17305/bb.2025.11386. Epub ahead of print. PMID: 40264369. 18: Adeoye AO, Olanlokun JO, Porta DJ, Akinyelu JO, Rivoira MA, Garcia NH. Antioxidative Potential and Activity of Potassium Polyacrylate and Coenzyme Q10 on Rat Hepatic Mitochondrial Permeability Transition Pores. Arch Razi Inst. 2024 Aug 1;79(4):805-814. doi: 10.32592/ARI.2024.79.4.805. PMID: 40256570; PMCID: PMC12004049. 19: Dong SH, Gao Y, Li Y, Wu D, Chen Y, Chen SH. Coenzyme Q10 microemulsion ion- activated gel: a promising ophthalmic delivery system for enhanced corneal protection and sustained release. BMC Pharmacol Toxicol. 2025 Apr 19;26(1):87. doi: 10.1186/s40360-025-00922-2. PMID: 40253426; PMCID: PMC12008920. 20: Freitas JA, Nehmi Filho V, Santamarina AB, Murata GM, Franco LAM, Fonseca JV, Martins RC, Souza GA, Benicio G, Sabbag IM, de Souza EA, Otoch JP, Pessoa AFM. Nutraceutical supplement slim reshaped colon histomorphology and reduces Mucispirillum schaedleri in obese mice. Front Microbiol. 2025 Apr 1;16:1494994. doi: 10.3389/fmicb.2025.1494994. PMID: 40236479; PMCID: PMC11997693.