MedKoo Cat#: 562727 | Name: GSK2163632A

Description:

WARNING: This product is for research use only, not for human or veterinary use.

GSK2163632A is an insulin-like growth factor 1 receptor inhibitor. It acts by binding to a novel region of the GRK active site cleft that could likely be exploited to achieve more selectivity.

Chemical Structure

GSK2163632A
GSK2163632A
CAS#1123163-20-1

Theoretical Analysis

MedKoo Cat#: 562727

Name: GSK2163632A

CAS#: 1123163-20-1

Chemical Formula: C27H32N8O3S

Exact Mass: 548.2318

Molecular Weight: 548.66

Elemental Analysis: C, 59.11; H, 5.88; N, 20.42; O, 8.75; S, 5.84

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
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Related CAS #
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Synonym
GSK2163632A; GSK-2163632-A; GSK 2163632 A;
IUPAC/Chemical Name
3-[[2-[[1-[2-(Dimethylamino)acetyl]-1,2,3,4-tetrahydro-6-methoxy-4,4-dimethyl-7-quinolinyl]amino]-7H-pyrrolo[2,3-d]pyrimidin-4-yl]amino]-2-thiophenecarboxamide
InChi Key
YNSCKPCDFIDINW-UHFFFAOYSA-N
InChi Code
InChI=1S/C27H32N8O3S/c1-27(2)8-10-35(21(36)14-34(3)4)19-13-18(20(38-5)12-16(19)27)31-26-32-24-15(6-9-29-24)25(33-26)30-17-7-11-39-22(17)23(28)37/h6-7,9,11-13H,8,10,14H2,1-5H3,(H2,28,37)(H3,29,30,31,32,33)
SMILES Code
O=C(C1=C(NC2=C3C(NC=C3)=NC(NC4=CC5=C(C=C4OC)C(C)(C)CCN5C(CN(C)C)=O)=N2)C=CS1)N
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>2 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 548.66 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Hawkinson JE, Sinville R, Mudaliar D, Shetty J, Ward T, Herr JC, Georg GI. Potent Pyrimidine and Pyrrolopyrimidine Inhibitors of Testis-Specific Serine/Threonine Kinase 2 (TSSK2). ChemMedChem. 2017 Nov 22;12(22):1857-1865. doi: 10.1002/cmdc.201700503. Epub 2017 Oct 20. PubMed PMID: 28952188. 2: Homan KT, Larimore KM, Elkins JM, Szklarz M, Knapp S, Tesmer JJ. Identification and structure-function analysis of subfamily selective G protein-coupled receptor kinase inhibitors. ACS Chem Biol. 2015 Jan 16;10(1):310-9. doi: 10.1021/cb5006323. Epub 2014 Oct 3. PubMed PMID: 25238254; PubMed Central PMCID: PMC4301037.