Propargyl-PEG4-methylamine is a PEG derivative containing a propargyl group and methylamine group. The propargyl group can be reacted with azide-bearing compounds or biomolecules via copper catalyzed azide-alkyne Click Chemistry to yield a stable triazole linkage. The methylamine group is reactive with carboxylic acids, activated NHS esters, carbonyls (ketone, aldehyde) etc. PEG Linkers are useful in the development of antibody drug conjugates.
MedKoo Cat#: 571729
Name: Propargyl-PEG4-methylamine
CAS#: 1807530-11-5
Chemical Formula: C12H23NO4
Exact Mass: 245.1627
Molecular Weight: 245.32
Elemental Analysis: C, 58.75; H, 9.45; N, 5.71; O, 26.09
The following data is based on the product molecular weight 245.32 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
