Synonym
N-Methylquipazine;NMethylquipazine; N Methylquipazine; J366.838J;
IUPAC/Chemical Name
2-(4-methylpiperazin-1-yl)quinoline
InChi Key
HOMWNUXPSJQSSU-UHFFFAOYSA-N
InChi Code
InChI=1S/C14H17N3/c1-16-8-10-17(11-9-16)14-7-6-12-4-2-3-5-13(12)15-14/h2-7H,8-11H2,1H3
SMILES Code
CN1CCN(C2=NC3=CC=CC=C3C=C2)CC1
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>2 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
Preparing Stock Solutions
The following data is based on the
product
molecular weight
227.14
Batch specific molecular weights may vary
from batch to batch
due to the degree of hydration, which will
affect the solvent
volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass |
1 mg |
5 mg |
10 mg |
| 1 mM |
1.15 mL |
5.76 mL |
11.51 mL |
| 5 mM |
0.23 mL |
1.15 mL |
2.3 mL |
| 10 mM |
0.12 mL |
0.58 mL |
1.15 mL |
| 50 mM |
0.02 mL |
0.12 mL |
0.23 mL |
1: Cappelli A, Giuliani G, Gallelli A, Valenti S, Anzini M, Mennuni L, Makovec F, Cupello A, Vomero S. Structure-affinity relationship studies on arylpiperazine derivatives related to quipazine as serotonin transporter ligands. Molecular basis of the selectivity SERT/5HT3 receptor. Bioorg Med Chem. 2005 May 16;13(10):3455-60. PubMed PMID: 15848758.
2: Morreale A, Gálvez-Ruano E, Iriepa-Canalda I, Boyd DB. Arylpiperazines with serotonin-3 antagonist activity: a comparative molecular field analysis. J Med Chem. 1998 Jun 4;41(12):2029-39. PubMed PMID: 9622544.
3: Thorell JO, Stone-Elander S, Eriksson L, Ingvar M. N-methylquipazine: carbon-11 labelling of the 5-HT3 agonist and in vivo evaluation of its biodistribution using PET. Nucl Med Biol. 1997 Jul;24(5):405-12. PubMed PMID: 9290075.
4: Kurata K, Ashby CR Jr, Oberlender R, Tanii Y, Kurachi M, Rini NJ, Strecker RE. The characterization of the effect of locally applied N-methylquipazine, a 5-HT3 receptor agonist, on extracellular dopamine levels in the anterior medial prefrontal cortex in the rat: an in vivo microdialysis study. Synapse. 1996 Dec;24(4):313-21. PubMed PMID: 10638822.
5: Glennon RA, Ismaiel AE, McCarthy BG, Peroutka SJ. Binding of arylpiperazines to 5-HT3 serotonin receptors: results of a structure-affinity study. Eur J Pharmacol. 1989 Sep 22;168(3):387-92. PubMed PMID: 2583244.
