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MedKoo Cat#: 596038 | Name: PF-00217830

Description:

WARNING: This product is for research use only, not for human or veterinary use.

PF-00217830 is a Dopamine D2 receptor agonist, Serotonin 1A receptor agonist, and Serotonin 2A receptor antagonists.

Chemical Structure

PF-00217830
CAS#846032-02-8

Theoretical Analysis

MedKoo Cat#: 596038

Name: PF-00217830

CAS#: 846032-02-8

Chemical Formula: C26H30N4O2

Exact Mass: 430.2369

Molecular Weight: 430.55

Elemental Analysis: C, 72.53; H, 7.02; N, 13.01; O, 7.43

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
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Related CAS #
No Data
Synonym
PF-00217830
IUPAC/Chemical Name
7-(4-(4-(naphthalen-1-yl)piperazin-1-yl)butoxy)-3,4-dihydro-1,8-naphthyridin-2(1H)-one
InChi Key
QGNOXTFZOLDODX-UHFFFAOYSA-N
InChi Code
InChI=1S/C26H30N4O2/c31-24-12-10-21-11-13-25(28-26(21)27-24)32-19-4-3-14-29-15-17-30(18-16-29)23-9-5-7-20-6-1-2-8-22(20)23/h1-2,5-9,11,13H,3-4,10,12,14-19H2,(H,27,28,31)
SMILES Code
O=C1NC2=NC(OCCCCN3CCN(C4=C5C=CC=CC5=CC=C4)CC3)=CC=C2CC1
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>2 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 430.55 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Zhao SX, Wang WW, Walker GS, Zhang L, Obach RS. Metabolism of a dopamine receptor partial agonist in rats, including an unusual N-dearylation reaction. Drug Metab Pharmacokinet. 2011 Jun;26(3):266-79. doi: 10.2133/dmpk.DMPK-10-RG-109. Epub 2011 Mar 4. PubMed PMID: 21383524. 2: Johnson DS, Choi C, Fay LK, Favor DA, Repine JT, White AD, Akunne HC, Fitzgerald L, Nicholls K, Snyder BJ, Whetzel SZ, Zhang L, Serpa KA. Discovery of PF-00217830: aryl piperazine napthyridinones as D2 partial agonists for schizophrenia and bipolar disorder. Bioorg Med Chem Lett. 2011 May 1;21(9):2621-5. doi: 10.1016/j.bmcl.2011.01.059. Epub 2011 Jan 22. PubMed PMID: 21353774.