MedKoo Cat#: 596021 | Name: Normirtazapine

Description:

WARNING: This product is for research use only, not for human or veterinary use.

N-desmethylmirtazapine is a metabolite of mirtazapine. Mirtazapine (Remeron, Avanza, Zispin) is a noradrenergic and specific serotonergic antidepressant (NaSSA) which was introduced by Organon International in the United States in 1990 and is used primarily in the treatment of depression. It is also commonly used as an anxiolytic, hypnotic, antiemetic, and appetite stimulant. Structurally, mirtazapine can also be classified as a tetracyclic antidepressant (TeCA).

Chemical Structure

Normirtazapine
Normirtazapine
CAS#61337-68-6

Theoretical Analysis

MedKoo Cat#: 596021

Name: Normirtazapine

CAS#: 61337-68-6

Chemical Formula: C16H17N3

Exact Mass: 251.1422

Molecular Weight: 251.33

Elemental Analysis: C, 76.46; H, 6.82; N, 16.72

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
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Related CAS #
No Data
Synonym
Normirtazapine; J1.061.658A; ORG-3838; ORG 3838; ORG3838; N-Desmethylmirtazapine; N-Demethylmirtazapine; Desmethyl mirtazapine; Desmethylmirtazapine;
IUPAC/Chemical Name
1,2,3,4,10,14b-hexahydrobenzo[c]pyrazino[1,2-a]pyrido[3,2-f]azepine
InChi Key
FGLAMNFOHWVQOH-UHFFFAOYSA-N
InChi Code
InChI=1S/C16H17N3/c1-2-6-14-12(4-1)10-13-5-3-7-18-16(13)19-9-8-17-11-15(14)19/h1-7,15,17H,8-11H2
SMILES Code
N12C3=NC=CC=C3CC4=CC=CC=C4C1CNCC2
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>2 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 251.33 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Paulzen M, Gründer G, Tauber SC, Veselinovic T, Hiemke C, Groppe SE. Distribution pattern of mirtazapine and normirtazapine in blood and CSF. Psychopharmacology (Berl). 2015 Feb;232(4):807-13. doi: 10.1007/s00213-014-3717-9. Epub 2014 Aug 23. PubMed PMID: 25150039. 2: Morgan PE, Tapper J, Spencer EP. Measurement of total mirtazapine and normirtazapine in plasma/serum by liquid chromatography with fluorescence detection. J Chromatogr B Analyt Technol Biomed Life Sci. 2003 Dec 25;798(2):211-5. PubMed PMID: 14643499.