Synonym
Mitoclomine; NSC 114575; NSC-114575; NSC114575; WBA 7707.
IUPAC/Chemical Name
1-Naphthalenamine, N,N-bis(2-chloroethyl)-4-methoxy-3-methyl- (9CI)
InChi Key
CLZXREZAEIUCGG-UHFFFAOYSA-N
InChi Code
InChI=1S/C16H19Cl2NO/c1-12-11-15(19(9-7-17)10-8-18)13-5-3-4-6-14(13)16(12)20-2/h3-6,11H,7-10H2,1-2H3
SMILES Code
CC1=CC(N(CCCl)CCCl)=C2C=CC=CC2=C1OC
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>2 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
Preparing Stock Solutions
The following data is based on the
product
molecular weight
312.23
Batch specific molecular weights may vary
from batch to batch
due to the degree of hydration, which will
affect the solvent
volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass |
1 mg |
5 mg |
10 mg |
| 1 mM |
1.15 mL |
5.76 mL |
11.51 mL |
| 5 mM |
0.23 mL |
1.15 mL |
2.3 mL |
| 10 mM |
0.12 mL |
0.58 mL |
1.15 mL |
| 50 mM |
0.02 mL |
0.12 mL |
0.23 mL |
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5: Meyniel G, Godenech D. [Relationship of labeled molecules in the pharmacokinetic study of alkylating agents (chlorambucil, melphalan, mitoclomine) and glycosyl nitrosoureas (RFCNU and RPCNU)]. Nouv Rev Fr Hematol. 1979;Suppl:XXXIII-XXXV. French. PubMed PMID: 545309.
6: Godeneche D, Madelmont JC, Moreau MF, Plagne R. Disposition of a new alkylating agent [14C]mitoclomine (N,N-bis(2'-chloroethyl)4-amino-2-methyl-1-methoxy-naphthalene). Xenobiotica. 1978 Oct;8(10):597-603. PubMed PMID: 716471.
7: Longeval E, Ganglji D, Stryckmans P, Kenis Y. Phase I-II clinical trial with mitoclomine (NSC-114575) in chronic lymphocytic leukemia. Cancer Chemother Rep. 1975 Nov-Dec;59(6):1173-5. PubMed PMID: 769961.
8: Fox M, Rees RW, Bennett DH, Henry L. Investigations into the lymphopaenic and immunosuppressive properties of the antitumour agent, mitoclomine. Lymphology. 1971 Jun;4(2):35-47. PubMed PMID: 5089346.
