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MedKoo Cat#: 562693 | Name: SR-3576
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Description:

WARNING: This product is for research use only, not for human or veterinary use.

SR-3576 is a potent JNK3 inhibitor that is highly selective over p38.

Chemical Structure

SR-3576
SR-3576
CAS#1164153-22-3

Theoretical Analysis

MedKoo Cat#: 562693

Name: SR-3576

CAS#: 1164153-22-3

Chemical Formula: C27H27N5O5

Exact Mass: 501.2012

Molecular Weight: 501.54

Elemental Analysis: C, 64.66; H, 5.43; N, 13.96; O, 15.95

Price and Availability

Size Price Availability Quantity
1mg USD 150.00 2 Weeks
5mg USD 400.00 2 Weeks
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Related CAS #
No Data
Synonym
SR-3576; SR 3576; SR3576;
IUPAC/Chemical Name
3-[4-(3-m-Tolyl-ureido)-pyrazol-1-yl]-N-(3,4,5-trimethoxy-phenyl)-benzamide
InChi Key
MTFAYLZZDJGFGV-UHFFFAOYSA-N
InChi Code
InChI=1S/C27H27N5O5/c1-17-7-5-9-19(11-17)30-27(34)31-21-15-28-32(16-21)22-10-6-8-18(12-22)26(33)29-20-13-23(35-2)25(37-4)24(14-20)36-3/h5-16H,1-4H3,(H,29,33)(H2,30,31,34)
SMILES Code
O=C(NC1=CC(OC)=C(OC)C(OC)=C1)C2=CC=CC(N3N=CC(NC(NC4=CC=CC(C)=C4)=O)=C3)=C2
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>2 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info
Product Data
Product Data
Instruction
View handling instruction
Biological target:
SR-3576 is a JNK3 inhibitor (IC50 = 7 nM) that is selective for JNK3 over JNK1 and p38 MAP kinase (IC50s = 0.17 and >20 µM, respectively). It inhibits c-Jun phosphorylation in INS-1 cells (IC50 = 1.3 µM).
In vitro activity:
Inhibitors from the aminopyrazole class, such as SR-3576, were very potent JNK3 inhibitors (IC(50) = 7 nm) with >2800-fold selectivity over p38 (p38 IC(50) > 20 microm) and had cell-based potency of approximately 1 microm. Reference: J Biol Chem. 2009 May 8;284(19):12853-61. https://pubmed.ncbi.nlm.nih.gov/19261605/
In vivo activity:
To be determined
Solvent mg/mL mM comments
Solubility
DMSO 40.0 79.75
Note: There can be variations in solubility for the same chemical from different vendors or different batches from the same vendor. The following factors can affect the solubility of the same chemical: solvent used for crystallization, residual solvent content, polymorphism, salt versus free form, degree of hydration, solvent temperature. Please use the solubility data as a reference only. Warming and sonication will facilitate dissolving. Still have questions? Please contact our Technical Support scientists.

Preparing Stock Solutions

The following data is based on the product molecular weight 501.54 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
1. Kamenecka T, Habel J, Duckett D, Chen W, Ling YY, Frackowiak B, Jiang R, Shin Y, Song X, LoGrasso P. Structure-activity relationships and X-ray structures describing the selectivity of aminopyrazole inhibitors for c-Jun N-terminal kinase 3 (JNK3) over p38. J Biol Chem. 2009 May 8;284(19):12853-61. doi: 10.1074/jbc.M809430200. Epub 2009 Mar 4. PMID: 19261605; PMCID: PMC2676016.
In vitro protocol:
1. Kamenecka T, Habel J, Duckett D, Chen W, Ling YY, Frackowiak B, Jiang R, Shin Y, Song X, LoGrasso P. Structure-activity relationships and X-ray structures describing the selectivity of aminopyrazole inhibitors for c-Jun N-terminal kinase 3 (JNK3) over p38. J Biol Chem. 2009 May 8;284(19):12853-61. doi: 10.1074/jbc.M809430200. Epub 2009 Mar 4. PMID: 19261605; PMCID: PMC2676016.
In vivo protocol:
To be determined
1: Kamenecka T, Habel J, Duckett D, Chen W, Ling YY, Frackowiak B, Jiang R, Shin Y, Song X, LoGrasso P. Structure-activity relationships and X-ray structures describing the selectivity of aminopyrazole inhibitors for c-Jun N-terminal kinase 3 (JNK3) over p38. J Biol Chem. 2009 May 8;284(19):12853-61. doi: 10.1074/jbc.M809430200. Epub 2009 Mar 4. PubMed PMID: 19261605; PubMed Central PMCID: PMC2676016.

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