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MedKoo Cat#: 562684 | Name: GP17

Description:

WARNING: This product is for research use only, not for human or veterinary use.

GP17 is a type II kinase inhibitor of the IRE1α endoribonuclease. It acts by targeting ATP-binding pocket of IRE1α.

Chemical Structure

GP17
GP17
CAS#1415050-57-5

Theoretical Analysis

MedKoo Cat#: 562684

Name: GP17

CAS#: 1415050-57-5

Chemical Formula: C26H21F3N4O

Exact Mass: 462.1667

Molecular Weight: 462.47

Elemental Analysis: C, 67.52; H, 4.58; F, 12.32; N, 12.11; O, 3.46

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
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Related CAS #
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Synonym
GP17; GP 17; GP-17;
IUPAC/Chemical Name
N-[3-[2-(Cyclopropylamino)-6-quinazolinyl]-4-methylphenyl]-3-(trifluoromethyl)-benzamide
InChi Key
BYBFDHQBBWQPTD-UHFFFAOYSA-N
InChi Code
InChI=1S/C26H21F3N4O/c1-15-5-7-21(31-24(34)17-3-2-4-19(12-17)26(27,28)29)13-22(15)16-6-10-23-18(11-16)14-30-25(33-23)32-20-8-9-20/h2-7,10-14,20H,8-9H2,1H3,(H,31,34)(H,30,32,33)
SMILES Code
O=C(NC1=CC=C(C)C(C2=CC3=CN=C(NC4CC4)N=C3C=C2)=C1)C5=CC=CC(C(F)(F)F)=C5
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>2 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 462.47 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
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Genetic variation for induced and basal resistance against leaf pathogen Pseudomonas syringae pv. tomato DC3000 among Arabidopsis thaliana accessions. Springerplus. 2015 Jun 26;4:296. doi: 10.1186/s40064-015-1070-z. eCollection 2015. PubMed PMID: 26140260; PubMed Central PMCID: PMC4481244. 8: Guo Y, Kragelund BB, White MF, Peng X. Functional characterization of a conserved archaeal viral operon revealing single-stranded DNA binding, annealing and nuclease activities. J Mol Biol. 2015 Jun 19;427(12):2179-91. doi: 10.1016/j.jmb.2015.03.013. Epub 2015 Mar 29. PubMed PMID: 25828870. 9: Wang T, Lin H, Zhang L, Huang G, Wu L, Yu L, Xiong H. Expression and purification of recombinant lyase gp17 from the LSB-1 phage in Escherichia coli. Virol Sin. 2015 Feb;30(1):69-72. doi: 10.1007/s12250-014-3527-6. PubMed PMID: 25628220. 10: Langlois C, Ramboarina S, Cukkemane A, Auzat I, Chagot B, Gilquin B, Ignatiou A, Petitpas I, Kasotakis E, Paternostre M, White HE, Orlova EV, Baldus M, Tavares P, Zinn-Justin S. Bacteriophage SPP1 tail tube protein self-assembles into β-structure-rich tubes. J Biol Chem. 2015 Feb 6;290(6):3836-49. doi: 10.1074/jbc.M114.613166. Epub 2014 Dec 17. PubMed PMID: 25525268; PubMed Central PMCID: PMC4319047. 11: Kondabagil K, Dai L, Vafabakhsh R, Ha T, Draper B, Rao VB. Designing a nine cysteine-less DNA packaging motor from bacteriophage T4 reveals new insights into ATPase structure and function. Virology. 2014 Nov;468-470:660-668. doi: 10.1016/j.virol.2014.08.033. Epub 2014 Oct 16. PubMed PMID: 25443668; PubMed Central PMCID: PMC4438746. 12: Migliori AD, Smith DE, Arya G. Molecular interactions and residues involved in force generation in the T4 viral DNA packaging motor. J Mol Biol. 2014 Dec 12;426(24):4002-4017. doi: 10.1016/j.jmb.2014.09.023. Epub 2014 Oct 13. PubMed PMID: 25311860; PubMed Central PMCID: PMC4376518. 13: Migliori AD, Keller N, Alam TI, Mahalingam M, Rao VB, Arya G, Smith DE. Evidence for an electrostatic mechanism of force generation by the bacteriophage T4 DNA packaging motor. Nat Commun. 2014 Jun 17;5:4173. doi: 10.1038/ncomms5173. PubMed PMID: 24937091; PubMed Central PMCID: PMC4157569. 14: Xu B, Ma X, Xiong H, Li Y. Complete genome sequence of 285P, a novel T7-like polyvalent E. coli bacteriophage. Virus Genes. 2014 Jun;48(3):528-33. doi: 10.1007/s11262-014-1059-7. Epub 2014 Mar 26. PubMed PMID: 24668157. 15: Auzat I, Petitpas I, Lurz R, Weise F, Tavares P. A touch of glue to complete bacteriophage assembly: the tail-to-head joining protein (THJP) family. Mol Microbiol. 2014 Mar;91(6):1164-78. doi: 10.1111/mmi.12526. Epub 2014 Feb 17. PubMed PMID: 24443902. 16: Nguyen HM, Kang C. Lysis delay and burst shrinkage of coliphage T7 by deletion of terminator Tφ reversed by deletion of early genes. J Virol. 2014 Feb;88(4):2107-15. doi: 10.1128/JVI.03274-13. Epub 2013 Dec 11. PubMed PMID: 24335287; PubMed Central PMCID: PMC3911561. 17: Guichard JA, Middleton PC, McConnell MR. Genetic analysis of structural proteins in the adsorption apparatus of bacteriophage epsilon 15. World J Virol. 2013 Nov 12;2(4):152-9. doi: 10.5501/wjv.v2.i4.152. PubMed PMID: 24286036; PubMed Central PMCID: PMC3832910. 18: Dixit AB, Ray K, Thomas JA, Black LW. The C-terminal domain of the bacteriophage T4 terminase docks on the prohead portal clip region during DNA packaging. Virology. 2013 Nov;446(1-2):293-302. doi: 10.1016/j.virol.2013.07.011. Epub 2013 Sep 7. PubMed PMID: 24074593; PubMed Central PMCID: PMC3903156. 19: Berkes E, Mužinić A, Rigo J Jr, Tinneberg HR, Oehmke F. The analysis of the human plasma N-glycome in endometriosis patients. Eur J Obstet Gynecol Reprod Biol. 2013 Nov;171(1):107-15. doi: 10.1016/j.ejogrb.2013.08.008. Epub 2013 Aug 13. 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