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MedKoo Cat#: 562679 | Name: SF5

Description:

WARNING: This product is for research use only, not for human or veterinary use.

SF5 is an inhibitor of the apoptosis pathway through JNK-p53-caspase apoptotic cascade.

Chemical Structure

SF5
SF5
CAS#34634-22-5

Theoretical Analysis

MedKoo Cat#: 562679

Name: SF5

CAS#: 34634-22-5

Chemical Formula: C15H13NS

Exact Mass: 239.0769

Molecular Weight: 239.33

Elemental Analysis: C, 75.28; H, 5.48; N, 5.85; S, 13.40

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
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Related CAS #
No Data
Synonym
SF5; SF-5; SF 5;
IUPAC/Chemical Name
1,1'-(2-Isothiocyanatoethylidene)bis-benzene
InChi Key
HCMJWOGOISXSDL-UHFFFAOYSA-N
InChi Code
InChI=1S/C15H13NS/c17-12-16-11-15(13-7-3-1-4-8-13)14-9-5-2-6-10-14/h1-10,15H,11H2
SMILES Code
S=C=NCC(C1=CC=CC=C1)C2=CC=CC=C2
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>2 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 239.33 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
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PubMed PMID: 29201061; PubMed Central PMCID: PMC5671752. 11: Mortimer SI, Hatcher S, Fogarty NM, van der Werf JHJ, Brown DJ, Swan AA, Jacob RH, Geesink GH, Hopkins DL, Edwards JEH, Ponnampalam EN, Warner RD, Pearce KL, Pethick DW. Genetic correlations between wool traits and meat quality traits in Merino sheep. J Anim Sci. 2017 Oct;95(10):4260-4273. doi: 10.2527/jas2017.1628. PubMed PMID: 29108061. 12: Angulo-Castro A, Ferrera-Cerrato R, Alarcón A, Almaraz-Suárez JJ, Delgadillo-Martínez J, Jiménez-Fernández M, García-Barradas O. [Growth and photochemical efficiency of photosystem ii in seedlings of two varieties of Capsicum annuum L. inoculated with rhizobacteria and arbuscular mycorrhizal fungi]. Rev Argent Microbiol. 2017 Oct 17. pii: S0325-7541(17)30108-6. doi: 10.1016/j.ram.2017.03.011. [Epub ahead of print] Spanish. PubMed PMID: 29054549. 13: Sansook S, Ocasio CA, Day IJ, Tizzard GJ, Coles SJ, Fedorov O, Bennett JM, Elkins JM, Spencer J. Synthesis of kinase inhibitors containing a pentafluorosulfanyl moiety. Org Biomol Chem. 2017 Oct 18;15(40):8655-8660. doi: 10.1039/c7ob02289a. PubMed PMID: 28984325; PubMed Central PMCID: PMC5708334. 14: Gautam P, Yu CP, Zhang G, Hillier VE, Chan JMW. Pulling with the Pentafluorosulfanyl Acceptor in Push-Pull Dyes. J Org Chem. 2017 Oct 20;82(20):11008-11020. doi: 10.1021/acs.joc.7b01972. Epub 2017 Oct 12. PubMed PMID: 28945090. 15: Shen W, Zhang W, Zhu C. Theoretical study of the substituent effect controlling the radiative and non-radiative decay processes of platinum(ii) complexes. Phys Chem Chem Phys. 2017 Aug 30;19(34):23532-23540. doi: 10.1039/c7cp04376g. PubMed PMID: 28829465. 16: Sowaileh MF, Hazlitt RA, Colby DA. Application of the Pentafluorosulfanyl Group as a Bioisosteric Replacement. ChemMedChem. 2017 Sep 21;12(18):1481-1490. doi: 10.1002/cmdc.201700356. Epub 2017 Sep 14. Review. PubMed PMID: 28782186. 17: Koziakov D, Jacobi von Wangelin A. Metal-free radical aromatic carbonylations mediated by weak bases. Org Biomol Chem. 2017 Aug 16;15(32):6715-6719. doi: 10.1039/c7ob01572k. PubMed PMID: 28770941. 18: Moraski GC, Bristol R, Seeger N, Boshoff HI, Tsang PS, Miller MJ. Preparation and Evaluation of Potent Pentafluorosulfanyl-Substituted Anti-Tuberculosis Compounds. ChemMedChem. 2017 Jul 20;12(14):1108-1115. doi: 10.1002/cmdc.201700170. Epub 2017 Jun 27. PubMed PMID: 28654200; PubMed Central PMCID: PMC5603227. 19: Pal AK, Henwood AF, Cordes DB, Slawin AMZ, Samuel IDW, Zysman-Colman E. Blue-to-Green Emitting Neutral Ir(III) Complexes Bearing Pentafluorosulfanyl Groups: A Combined Experimental and Theoretical Study. Inorg Chem. 2017 Jul 3;56(13):7533-7544. doi: 10.1021/acs.inorgchem.7b01075. Epub 2017 Jun 14. PubMed PMID: 28613074; PubMed Central PMCID: PMC5499099. 20: Groves LM, Schotten C, Beames J, Platts JA, Coles SJ, Horton PN, Browne DL, Pope SJA. 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BMS-488043

BMS-488043