COR627 | CAS#329221-34-3 | GABA(B) receptor modulator

MedKoo Cat#: 562677 | Name: COR627

Description:

WARNING: This product is for research use only, not for human or veterinary use.

COR627 is a positive allosteric modulator of the GABA(B) receptor.

Chemical Structure

COR627

CAS#329221-34-3

Theoretical Analysis

MedKoo Cat#: 562677

Name: COR627

CAS#: 329221-34-3

Chemical Formula: C20H27NO3S

Exact Mass: 361.1712

Molecular Weight: 361.50

Elemental Analysis: C, 66.45; H, 7.53; N, 3.87; O, 13.28; S, 8.87

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.

Bulk Inquiry

Related CAS #

No Data

Synonym

COR627; COR-627; COR 627;

IUPAC/Chemical Name

Methyl 2-(1-adamantanecarboxamido)-4-ethyl-5-methylthiophene-3-carboxylate

InChi Key

NRZDWDWUMMFBOW-UHFFFAOYSA-N

InChi Code

InChI=1S/C20H27NO3S/c1-4-15-11(2)25-17(16(15)18(22)24-3)21-19(23)20-8-12-5-13(9-20)7-14(6-12)10-20/h12-14H,4-10H2,1-3H3,(H,21,23)

SMILES Code

O=C(C1=C(NC(C23CC4CC(C3)CC(C4)C2)=O)SC(C)=C1CC)OC

Appearance

Solid powder

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

Soluble in DMSO

Shelf Life

>2 years if stored properly

Drug Formulation

This drug may be formulated in DMSO

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.9001

More Info

Instruction

View handling instruction

Preparing Stock Solutions

The following data is based on the product molecular weight 361.50 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

1: Mugnaini C, Pedani V, Casu A, Lobina C, Casti A, Maccioni P, Porcu A, Giunta D, Lamponi S, Solinas M, Dragoni S, Valoti M, Colombo G, Castelli MP, Gessa GL, Corelli F. Synthesis and pharmacological characterization of 2-(acylamino)thiophene derivatives as metabolically stable, orally effective, positive allosteric modulators of the GABAB receptor. J Med Chem. 2013 May 9;56(9):3620-35. doi: 10.1021/jm400144w. Epub 2013 Apr 18. PubMed PMID: 23544432. 2: Castelli MP, Casu A, Casti P, Lobina C, Carai MA, Colombo G, Solinas M, Giunta D, Mugnaini C, Pasquini S, Tafi A, Brogi S, Gessa GL, Corelli F. Characterization of COR627 and COR628, two novel positive allosteric modulators of the GABA(B) receptor. J Pharmacol Exp Ther. 2012 Mar;340(3):529-38. doi: 10.1124/jpet.111.186460. Epub 2011 Nov 30. PubMed PMID: 22129594.