MedKoo Cat#: 596010 | Name: Formothion
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Description:

WARNING: This product is for research use only, not for human or veterinary use.

Formothion is a chemical compound used in acaricides and insecticides.

Chemical Structure

Formothion
Formothion
CAS#2540-82-1

Theoretical Analysis

MedKoo Cat#: 596010

Name: Formothion

CAS#: 2540-82-1

Chemical Formula: C6H12NO4PS2

Exact Mass: 256.9945

Molecular Weight: 257.25

Elemental Analysis: C, 28.01; H, 4.70; N, 5.44; O, 24.88; P, 12.04; S, 24.92

Price and Availability

Size Price Availability Quantity
250mg USD 450.00 Back order
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Related CAS #
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Synonym
Formothion; Anthio; Toprose; Aflix
IUPAC/Chemical Name
Phosphorodithioic acid, S-(2-(formylmethylamino)-2-oxoethyl) O,O-dimethyl ester
InChi Key
AIKKULXCBHRFOS-UHFFFAOYSA-N
InChi Code
InChI=1S/C6H12NO4PS2/c1-7(5-8)6(9)4-14-12(13,10-2)11-3/h5H,4H2,1-3H3
SMILES Code
S=P(OC)(SCC(N(C=O)C)=O)OC
Appearance
Liqiud (~80% in xylene)
Purity
>75% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>2 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 257.25 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Kuo TC, Hu CC, Chien TY, Chen MJ, Feng HT, Chen LF, Chen CY, Hsu JC. Discovery of genes related to formothion resistance in oriental fruit fly (Bactrocera dorsalis) by a constrained functional genomics analysis. Insect Mol Biol. 2015 Jun;24(3):338-47. doi: 10.1111/imb.12161. Epub 2015 Feb 20. PMID: 25702834. 2: Kojima T, Yashiki M, Ohtani M, Chikasue F, Miyazaki T. Determination of dimethoate in blood and hemoperfusion cartridge following ingestion of formothion: a case study. Forensic Sci Int. 1990 Nov;48(1):79-88. doi: 10.1016/0379-0738(90)90274-3. PMID: 2126251. 3: KLOTZSCHE C. [Formothion, a new systematic phosphoric acid ester with low toxicity]. Mitt Geb Lebensmittelunters Hyg. 1961;52:340-9. German. PMID: 14457136. 4: Singh NN, Srivastava AK. Effect of formothion on carbohydrate metabolism in indian catfish, Heteropneustes fossilis. Environ Res. 1982 Aug;28(2):335-9. doi: 10.1016/0013-9351(82)90132-3. PMID: 6811263. 5: Sauer HH, Bosshardt HP. Collaborative study of two analytical methods for the analysis of Formothion formulations. J Assoc Off Anal Chem. 1974 Jul;57(4):771-7. PMID: 4417527. 6: Clément M, Arzel S, Le Bot B, Seux R, Millet M. Adsorption/thermal desorption-GC/MS for the analysis of pesticides in the atmosphere. Chemosphere. 2000 Jan;40(1):49-56. doi: 10.1016/s0045-6535(99)00230-1. PMID: 10665444. 7: Rodríguez E, Campos M, Sánchez Raya AJ, Peña A. Effect of the combined treatment of insecticides and an attractant for the control of Phloeotribus scarabaeoides, a pest of Olea europea. Pest Manag Sci. 2003 Mar;59(3):339-46. doi: 10.1002/ps.643. PMID: 12639052. 8: Hussein BH, Khairy GM, Kamel RM. Fluorescence sensing of phosdrin pesticide by the luminescent Eu(III)- and Tb(III)-bis(coumarin-3-carboxylic acid) probes. Spectrochim Acta A Mol Biomol Spectrosc. 2016 Apr 5;158:34-42. doi: 10.1016/j.saa.2016.01.008. Epub 2016 Jan 11. PMID: 26802539. 9: Klotzsche C. Teratologische und embryotoxische Untersuchungen mit Formothion und Thiometon [Teratologic and embryotoxic studies with formothion and thiometon]. Pharm Acta Helv. 1970 Jul;45(7):434-40. German. PMID: 5531092. 10: Klotzsche C. Toxikologische Untersuchungen mit dem systemischen Phosphoräureester Formothion [Toxicologic studies on the systemic phosphoric acid ester Formothion]. Int Arch Arbeitsmed. 1966 Aug 17;22(3):246-61. German. PMID: 5984988. 11: Lamnoi S, Boonupara T, Sumitsawan S, Vongruang P, Prapamontol T, Udomkun P, Kajitvichyanukul P. Unveiling the Aftermath: Exploring Residue Profiles of Insecticides, Herbicides, and Fungicides in Rice Straw, Soils, and Air Post- Mixed Pesticide-Contaminated Biomass Burning. Toxics. 2024 Jan 18;12(1):86. doi: 10.3390/toxics12010086. PMID: 38251041; PMCID: PMC10819870. 12: Hsu JC, Feng HT, Wu WJ. Resistance and synergistic effects of insecticides in Bactrocera dorsalis (Diptera: Tephritidae) in Taiwan. J Econ Entomol. 2004 Oct;97(5):1682-8. doi: 10.1603/0022-0493-97.5.1682. PMID: 15568360. 13: Singh DK, Agarwal RA. Inhibition kinetics of certain organophosphorus and carbamate pesticides on acetylcholinesterase from the snail Lymnaea acuminata. Toxicol Lett. 1983 Dec;19(3):313-9. doi: 10.1016/0378-4274(83)90136-4. PMID: 6658844. 14: Stone BF, Wilson JT, Youlton NJ. Linkage and dominance characteristics of genes for resistance to organophosphorus acaricides and allelic inheritance of decreased brain cholinesterase activity in three strains of the cattle tick, Boophilus microplus. Aust J Biol Sci. 1976 Jul;29(3):251-63. doi: 10.1071/bi9760251. PMID: 985225. 15: Sancewicz-Pach K, Groszek B, Pach D, Kłys M. Acute pesticides poisonings in pregnant women. Przegl Lek. 1997;54(10):741-4. PMID: 9478098. 16: Agarwal G, Tichenor H, Roo S, Lane TR, Ekins S, McElroy CA. Targeted Metabolomics of Organophosphate Pesticides and Chemical Warfare Nerve Agent Simulants Using High- and Low-Dose Exposure in Human Liver Microsomes. Metabolites. 2023 Mar 29;13(4):495. doi: 10.3390/metabo13040495. PMID: 37110155; PMCID: PMC10144572. 17: Ferreira JR, Silva Fernandes AM. Gas-liquid chromatographic determination of organophosphorus insecticide residues in fruits and vegetables. J Assoc Off Anal Chem. 1980 May;63(3):517-22. PMID: 7430038. 18: Hsu JC, Feng HT. Development of resistance to spinosad in oriental fruit fly (Diptera: Tephritidae) in laboratory selection and cross-resistance. J Econ Entomol. 2006 Jun;99(3):931-6. doi: 10.1603/0022-0493-99.3.931. PMID: 16813333. 19: Nocchi N, Duarte HM, Pereira RC, Konno TUP, Soares AR. Effects of UV-B radiation on secondary metabolite production, antioxidant activity, photosynthesis and herbivory interactions in Nymphoides humboldtiana (Menyanthaceae). J Photochem Photobiol B. 2020 Nov;212:112021. doi: 10.1016/j.jphotobiol.2020.112021. Epub 2020 Sep 10. PMID: 32957070. 20: Awal MD, Saifuddin AK. The effect of long-term exposure to anthio on serum esterases and ruminal microorganisms of male calves. Vet Hum Toxicol. 1994 Jun;36(3):199-202. PMID: 8066963.