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MedKoo Cat#: 562668 | Name: Indatraline HCl
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Description:

WARNING: This product is for research use only, not for human or veterinary use.

Indatraline HCl is a potent inhibitor of dopamine, norepinephrine and serotonin uptake.

Chemical Structure

Indatraline HCl
Indatraline HCl
CAS#96850-13-4

Theoretical Analysis

MedKoo Cat#: 562668

Name: Indatraline HCl

CAS#: 96850-13-4

Chemical Formula: C16H16Cl3N

Exact Mass:

Molecular Weight: 328.66

Elemental Analysis: C, 58.47; H, 4.91; Cl, 32.36; N, 4.26

Price and Availability

Size Price Availability Quantity
10mg USD 450.00 2 Weeks
25mg USD 850.00 2 Weeks
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Related CAS #
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Synonym
Indatraline HCl; Indatraline HCl salt; Indatraline Hydrochloride; Indatraline Hydrochloride salt;
IUPAC/Chemical Name
(1R,3S)-3-(3,4-dichlorophenyl)-N-methyl-2,3-dihydro-1H-inden-1-amine hydrochloride
InChi Key
QICQDZXGZOVTEF-MELYUZJYSA-N
InChi Code
InChI=1S/C16H15Cl2N.ClH/c1-19-16-9-13(11-4-2-3-5-12(11)16)10-6-7-14(17)15(18)8-10;/h2-8,13,16,19H,9H2,1H3;1H/t13-,16+;/m0./s1
SMILES Code
CN[C@@H]1C[C@@H](C2=CC=C(Cl)C(Cl)=C2)C3=C1C=CC=C3.[H]Cl
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>2 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info
Product Data
Product Data
Instruction
View handling instruction
Biological target:
Indatraline hydrochloride (Lu 19-005) is a non-selective monoamine transporter inhibitor that blocks the reuptake of neurotransmitters (dopamine, serotonin, and norepinephrine) with efficacy similar to cocaine.
In vitro activity:
Cells treated with 5 μM and 10 μM of indatraline in the presence of E64D showed increases of 2-fold and 3-fold, respectively, compared to cells treated with indatraline alone (Fig. 2D). Accordingly, these results demonstrate that indatraline leads to an increase in autophagic flux. Reference: Sci Rep. 2016 Oct 3;6:34655. https://pubmed.ncbi.nlm.nih.gov/27694974/
In vivo activity:
Behavioral tests were conducted to evaluate the effect of indatraline and of its precursor indanamide on the motor activity of Wistar rats. Specific indexes for ambulation, raising and stereotypy were computed one, two and three hours after i.p. drug administration. Indatraline effects on motor activity lasted for at least three hours. Reference: Molecules. 2011 Nov 10;16(11):9421-38. https://pubmed.ncbi.nlm.nih.gov/22075572/
Solvent mg/mL mM
Solubility
DMSO 32.9 100.00
Water 3.3 10.01
Note: There can be variations in solubility for the same chemical from different vendors or different batches from the same vendor. The following factors can affect the solubility of the same chemical: solvent used for crystallization, residual solvent content, polymorphism, salt versus free form, degree of hydration, solvent temperature. Please use the solubility data as a reference only. Warming and sonication will facilitate dissolving. Still have questions? Please contact our Technical Support scientists.

Preparing Stock Solutions

The following data is based on the product molecular weight 328.66 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
1. Cho YS, Yen CN, Shim JS, Kang DH, Kang SW, Liu JO, Kwon HJ. Antidepressant indatraline induces autophagy and inhibits restenosis via suppression of mTOR/S6 kinase signaling pathway. Sci Rep. 2016 Oct 3;6:34655. doi: 10.1038/srep34655. PMID: 27694974; PMCID: PMC5046148. 2. Kameyama M, Siqueira FA, Garcia-Mijares M, Silva LF Jr, Silva MT. Indatraline: synthesis and effect on the motor activity of Wistar rats. Molecules. 2011 Nov 10;16(11):9421-38. doi: 10.3390/molecules16119421. PMID: 22075572; PMCID: PMC6264188.
In vitro protocol:
1. Cho YS, Yen CN, Shim JS, Kang DH, Kang SW, Liu JO, Kwon HJ. Antidepressant indatraline induces autophagy and inhibits restenosis via suppression of mTOR/S6 kinase signaling pathway. Sci Rep. 2016 Oct 3;6:34655. doi: 10.1038/srep34655. PMID: 27694974; PMCID: PMC5046148.
In vivo protocol:
1. Kameyama M, Siqueira FA, Garcia-Mijares M, Silva LF Jr, Silva MT. Indatraline: synthesis and effect on the motor activity of Wistar rats. Molecules. 2011 Nov 10;16(11):9421-38. doi: 10.3390/molecules16119421. PMID: 22075572; PMCID: PMC6264188.
1: Tirelli E, Geter-Douglass B, Witkin JM. gamma-Aminobutyric acidA agonists differentially augment gnawing induced by indirect-acting dopamine agonists in C57BL/6J mice. J Pharmacol Exp Ther. 1998 Jan;284(1):116-24. PubMed PMID: 9435169.