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MedKoo Cat#: 341562 | Name: Alclofenac
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Description:

WARNING: This product is for research use only, not for human or veterinary use.

Alclofenac may be used to treat patients with chronic rheumatic diseases. Research shows that alclofenac has a pronounced effect upon the acute-phase protein response and the extent to which L-tryptophan is bound to plasma protein.

Chemical Structure

Alclofenac
CAS#22131-79-9

Theoretical Analysis

MedKoo Cat#: 341562

Name: Alclofenac

CAS#: 22131-79-9

Chemical Formula: C11H11ClO3

Exact Mass: 226.0397

Molecular Weight: 226.66

Elemental Analysis: C, 58.29; H, 4.89; Cl, 15.64; O, 21.18

Price and Availability

Size Price Availability Quantity
25mg USD 400.00 2 Weeks
50mg USD 600.00 2 Weeks
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Related CAS #
No Data
Synonym
Alclofenac; W 7320; W-7320; W7320; MY 101; BRN 2116510.
IUPAC/Chemical Name
(4-(Allyloxy)-3-chlorophenyl)acetic acid
InChi Key
ARHWPKZXBHOEEE-UHFFFAOYSA-N
InChi Code
InChI=1S/C11H11ClO3/c1-2-5-15-10-4-3-8(6-9(10)12)7-11(13)14/h2-4,6H,1,5,7H2,(H,13,14)
SMILES Code
O=C(O)CC1=CC=C(OCC=C)C(Cl)=C1
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>2 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info
Short-term double-blind trials showed that alclofenac has analgesic/anti-inflammatory activities equivalent to phenylbutazone, indomethacin and aspirin, but superior to the fenemates and propionic acid derivatives. Long-term controlled studies, ranging from 5 months to 3-1/2 years and using reliable, objective measures revela, however, that patients with rheumatoid arthritis improve in functional status and graduate to less severe classes of disease activity, a phenomenon not observed with either indomethacin or aspirin administered to matched patients over the same periods of time.

Preparing Stock Solutions

The following data is based on the product molecular weight 226.66 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Knights KM, Winner LK, Elliot DJ, Bowalgaha K, Miners JO. Aldosterone glucuronidation by human liver and kidney microsomes and recombinant UDP-glucuronosyltransferases: inhibition by NSAIDs. Br J Clin Pharmacol. 2009 Sep;68(3):402-12. doi: 10.1111/j.1365-2125.2009.03469.x. PubMed PMID: 19740398; PubMed Central PMCID: PMC2766480. 2: Grimes DA, Hubacher D, Lopez LM, Schulz KF. Non-steroidal anti-inflammatory drugs for heavy bleeding or pain associated with intrauterine-device use. Cochrane Database Syst Rev. 2006 Oct 18;(4):CD006034. Review. PubMed PMID: 17054271. 3: Selinsky BS, Gupta K, Sharkey CT, Loll PJ. Structural analysis of NSAID binding by prostaglandin H2 synthase: time-dependent and time-independent inhibitors elicit identical enzyme conformations. Biochemistry. 2001 May 1;40(17):5172-80. PubMed PMID: 11318639. 4: Fillet M, Bechet I, Piette V, Crommen J. Separation of nonsteroidal anti-inflammatory drugs by capillary electrophoresis using nonaqueous electrolytes. Electrophoresis. 1999 Jul;20(9):1907-15. PubMed PMID: 10445335. 5: Delbeke FT, Landuyt J, Debackere M. Disposition of human drug preparations in the horse. III. Orally administered alclofenac. J Vet Pharmacol Ther. 1994 Oct;17(5):353-8. PubMed PMID: 7853459. 6: Lee CK, Uchida T, Kitagawa K, Yagi A, Kim NS, Goto S. Effect of hydrophilic and lipophilic vehicles on skin permeation of tegafur, alclofenac and ibuprofen with or without permeation enhancers. Biol Pharm Bull. 1993 Dec;16(12):1264-9. PubMed PMID: 7907514. 7: Delbeke FT, Landuyt J, Debackere M. Determination of alclofenac in equine plasma and urine by high-performance liquid chromatography. J Chromatogr. 1993 Nov 24;621(2):209-14. PubMed PMID: 7905004. 8: Uchida T, Lee CK, Sekiya N, Goto S. Enhancement effect of an ethanol/Panasate 800 binary vehicle on anti-inflammatory drug permeation across excised hairless mouse skin. Biol Pharm Bull. 1993 Feb;16(2):168-71. PubMed PMID: 8364453. 9: Kamiya Y, Nakabayashi K, Suzuki M, Motohashi S, Maemura C, Kitamoto K, Nagasawa T. [A case of concurrent occurrence of acute renal failure and nephrotic syndrome induced by alclofenac]. Nihon Naika Gakkai Zasshi. 1989 Jul;78(7):958-63. Japanese. PubMed PMID: 2571652. 10: de Jong EG, Kiffers J, Maes RA. The determination of non-steroidal anti-inflammatory drugs by GC-MS-MS in equine urine. J Pharm Biomed Anal. 1989;7(12):1617-22. PubMed PMID: 2490551. 11: Karzel K, Breuer NA. [Effects of antirheumatics on the glycosaminoglycan distribution pattern of fetal tibia cultured in vitro]. Arzneimittelforschung. 1988 Sep;38(9):1327-33. German. PubMed PMID: 3223972. 12: Schuermans Y, Rauis A. Comparative clinical trial of two injectable NSAIDs, tiaprofenic acid and alclofenac, in acute sciatica. Drugs. 1988;35 Suppl 1:83-5. PubMed PMID: 2896114. 13: Lin JH, Cocchetto DM, Duggan DE. Protein binding as a primary determinant of the clinical pharmacokinetic properties of non-steroidal anti-inflammatory drugs. Clin Pharmacokinet. 1987 Jun;12(6):402-32. Review. PubMed PMID: 3301150. 14: Chiba K, Kikuchi S, Nishimura S, Higuchi N, Miyazaki S, Takada M. Study of the interactions between sulfamethizole and alclofenac, diclofenac or tiaprofenic acid in rats. Chem Pharm Bull (Tokyo). 1987 Feb;35(2):882-6. PubMed PMID: 2885098. 15: Watanabe T, Suga T. Effects of some anti-inflammatory drugs on biochemical values and on hepatic peroxisomal enzymes of rat. J Pharmacobiodyn. 1985 Dec;8(12):1060-7. PubMed PMID: 3834060. 16: Zecchi V, Rodriguez L, Tartarini A, Fini A. Kinetic aspects of the dissolution and partition of diclofenac, alclofenac and their sodium salts. Arch Pharm (Weinheim). 1984 Nov;317(11):897-905. PubMed PMID: 6151384. 17: Dixon JS, Bird HA, Sitton NG, Pickup ME, Wright V. C-reactive protein in the serial assessment of disease activity in rheumatoid arthritis. Scand J Rheumatol. 1984;13(1):39-44. PubMed PMID: 6202005. 18: Mercier M, Poncelet F, de Meester C, McGregor DB, Willins MJ, Léonard A, Fabry L. In vitro and in vivo studies on the potential mutagenicity of alclofenac, dihydroxyalclofenac and alclofenac epoxide. J Appl Toxicol. 1983 Oct;3(5):230-6. PubMed PMID: 6141199. 19: Kadir N, Grayson MF, Campbell ED. A double-blind one year clinical trial comparing alclofenac with gold in rheumatoid arthritis. Ann Clin Res. 1983;15(1):4-9. PubMed PMID: 6134490. 20: Rafter GW. Etiology of rheumatoid arthritis. Med Hypotheses. 1982 Oct;9(4):437-43. PubMed PMID: 6984130.