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MedKoo Cat#: 341558 | Name: Oxisuran

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Oxisuran is a biochemical.

Chemical Structure

Oxisuran
Oxisuran
CAS#27302-90-5

Theoretical Analysis

MedKoo Cat#: 341558

Name: Oxisuran

CAS#: 27302-90-5

Chemical Formula: C8H9NO2S

Exact Mass: 183.0354

Molecular Weight: 183.23

Elemental Analysis: C, 52.44; H, 4.95; N, 7.64; O, 17.46; S, 17.50

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
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Related CAS #
No Data
Synonym
Oxisuran; W 6495; W-6495; W6495; NSC 356716; BRN 1526159.
IUPAC/Chemical Name
Ethanone, 2-(methylsulfinyl)-1-(2-pyridinyl)-
InChi Key
DSWLRNLRVBAVFC-UHFFFAOYSA-N
InChi Code
InChI=1S/C8H9NO2S/c1-12(11)6-8(10)7-4-2-3-5-9-7/h2-5H,6H2,1H3
SMILES Code
O=S(CC(C1=NC=CC=C1)=O)C
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>2 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 183.23 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: El Ouazzani H, Khiar N, Fernández I, Alcudia F. General Method for Asymmetric Synthesis of alpha-Methylsulfinyl Ketones: Application to the Synthesis of Optically Pure Oxisuran and Bioisosteres. J Org Chem. 1997 Jan 24;62(2):287-291. PubMed PMID: 11671400. 2: de la Iglesia FA, McGuire EJ. Rodent carcinogenesis bioassay with oxisuran, a selective immunosuppressive agent. Toxicology. 1983 Sep;28(1-2):17-28. PubMed PMID: 6688895. 3: Kazmers IS, Daddona PE, Dalke AP, Kelley WN. Effect of immunosuppressive agents on human T and B lymphoblasts. Biochem Pharmacol. 1983 Mar 1;32(5):805-10. PubMed PMID: 6404281. 4: Bixler GS Jr, Linna TJ. Oxisuran: influence on allograft rejection and graft versus host reactivity in chickens and mice. Immunopharmacology. 1982 Feb;4(1):79-85. PubMed PMID: 6895887. 5: Otterness IG. Comparative activity of CP-17,193 and five established immunosuppressives toward the antigens SRBC and EL4. Clin Exp Immunol. 1981 Nov;46(2):332-9. PubMed PMID: 7039885; PubMed Central PMCID: PMC1536394. 6: Giovanniello OA, Nejamkis MR, Galassi NV, Nota NR. Immunosuppression in experimental Junin virus infection of mice. Intervirology. 1980;13(2):122-5. PubMed PMID: 6246026. 7: Di Carlo FJ. Interspecies comparisons of oxisuran metabolism and pharmacokinetics. Drug Metab Rev. 1979;10(2):225-37. Review. PubMed PMID: 399459. 8: Caputo D, Altamura C, Bisaccia G, Ghezzi A, Manara F, Zibetti A. 2 [(methylsulfinyl) acetyl] pyridine (Oxisuran): a new immunosuppressive agent in EAE. Boll Ist Sieroter Milan. 1978 Sep 30;57(4):422-7. PubMed PMID: 581646. 9: Wilson FM 2nd, Smolin G, Jackson WB, Hall JM. The effect of oxisuran, a selective inhibitor of cellular immunity, on the rejection of bovine corneal xenografts in rabbits. Ann Ophthalmol. 1978 Mar;10(3):283-90. PubMed PMID: 350120. 10: Macario AJ, Conway de Macario E. Enhancement and inhibition of immunological mechanisms by immunosuppressive agents. I. Dose effect on priming and generation of memory to a bacterial antigen. Clin Exp Immunol. 1978 Feb;31(2):281-90. PubMed PMID: 417887; PubMed Central PMCID: PMC1541225. 11: Blackham A, Radziwonik H. The effect of drugs in established rabbit monoarticular arthritis. Agents Actions. 1977 Oct;7(4):473-80. PubMed PMID: 930758. 12: Leinweber FJ, Greenough RC, Di Carlo FJ. A new oxisuran metabolite. Xenobiotica. 1976 Oct;6(10):617-24. PubMed PMID: 989983. 13: Tan M, Nishihira T, Tsutsumi E, Kasai M. The effect of oxisuran on differential inhibition of cell-mediated immunity. Tohoku J Exp Med. 1976 Aug;119(4):333-7. PubMed PMID: 134470. 14: Tight RR, Perkins RL. Treponema pallidum infection in subcutaneous polyethylene chambers in rabbits. Infect Immun. 1976 Jun;13(6):1606-12. PubMed PMID: 786879; PubMed Central PMCID: PMC420808. 15: Bachur NR, Felsted RL. Oxisuran reduction by rabbit tissue preparations. Drug Metab Dispos. 1976 May-Jun;4(3):239-43. PubMed PMID: 6228. 16: Brizarelli G, Abrutyn D, Tornaben JA, Schwartz E. Safety evaluation studies on oxisuran, a differential inhibitor of cell-mediated hypersensitivity. Toxicol Appl Pharmacol. 1976 Apr;36(1):49-64. PubMed PMID: 946915. 17: Crew MC, Di Carlo F. Oxisuran metabolism in pigs. Drug Metab Dispos. 1976 Mar-Apr;4(2):147-53. PubMed PMID: 5259. 18: Di Carlo FJ. Oxisuran: a non-cytotoxic, differentially immunosuppressive agent. Adv Exp Med Biol. 1976;73 PT-A:467-71. PubMed PMID: 1036661. 19: DiMarco AT, Pizza G, Macario AJ, Prodi G. Differential effects of oxisuran on lymphocyte functions in vitro. Transplantation. 1976 Jan;21(1):66-9. PubMed PMID: 128858. 20: van Dijk H, Bakker IA, Testerink J, Bloksma N, Willers JM. Oxisuran and immune reactions: mediation of oxisuran action by the adrenal glands. J Immunol. 1975 Dec;115(6):1587-91. PubMed PMID: 1102602.

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