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MedKoo Cat#: 562658 | Name: α-NETA
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Description:

WARNING: This product is for research use only, not for human or veterinary use.

α-NETA is a CMKLR1 antagonist. It acts by suppressing CNS autoimmune inflammatory disease. α-NETA is also a fluorescent choactase inhibitor.

Chemical Structure

α-NETA
α-NETA
CAS#31059-54-8

Theoretical Analysis

MedKoo Cat#: 562658

Name: α-NETA

CAS#: 31059-54-8

Chemical Formula: C16H20INO

Exact Mass: 369.0590

Molecular Weight: 369.24

Elemental Analysis: C, 52.05; H, 5.46; I, 34.37; N, 3.79; O, 4.33

Price and Availability

Size Price Availability Quantity
5mg USD 400.00
25mg USD 600.00
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Related CAS #
No Data
Synonym
α-NETA; α NETA; αNETA; alpha NETA; alpha-NETA;
IUPAC/Chemical Name
N,N,N-trimethyl-3-(naphthalen-2-yl)-3-oxopropan-1-aminium iodide
InChi Key
LIFHUGCXEAQKRZ-UHFFFAOYSA-M
InChi Code
InChI=1S/C16H20NO.HI/c1-17(2,3)11-10-16(18)15-9-8-13-6-4-5-7-14(13)12-15;/h4-9,12H,10-11H2,1-3H3;1H/q+1;/p-1
SMILES Code
C[N+](C)(CCC(C1=CC=C2C=CC=CC2=C1)=O)C.[I-]
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>2 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 369.24 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Cruz-López EO, Tan L, Stolk DG, van den Bogaerdt AJ, Verdonk K, Danser AHJ. Endothelin-1- and acetylcholine-mediated effects in human and rat vessels: impact of perivascular adipose tissue, diabetes, angiotensin II, and chemerin. Blood Press. 2024 Dec;33(1):2414072. doi: 10.1080/08037051.2024.2414072. Epub 2024 Oct 10. PMID: 39387176. 2: Huang Y, Li S, Yang Y, Li K, Wen L, Li J. Chemerin 15 peptide reduces neuroinflammation via the ChemR23 receptor after ischemia-reperfusion injury. Neural Regen Res. 2024 Sep 6. doi: 10.4103/NRR.NRR-D-24-00137. Epub ahead of print. PMID: 39248165. 3: Hao WY, Wang JX, Xu XY, Chen JL, Chen Q, Li YH, Zhu GQ, Chen AD. Chemerin in caudal division of nucleus tractus solitarius increases sympathetic activity and blood pressure. Eur J Neurosci. 2024 Sep;60(5):4830-4842. doi: 10.1111/ejn.16475. Epub 2024 Jul 23. PMID: 39044301. 4: Wang D, Mahmud I, Thakur VS, Tan SK, Isom DG, Lombard DB, Gonzalgo ML, Kryvenko ON, Lorenzi PL, Tcheuyap VT, Brugarolas J, Welford SM. GPR1 and CMKLR1 Control Lipid Metabolism to Support the Development of Clear Cell Renal Cell Carcinoma. Cancer Res. 2024 Jul 2;84(13):2141-2154. doi: 10.1158/0008-5472.CAN-23-2926. PMID: 38640229; PMCID: PMC11290988. 5: Jin Z, Shen Z, Yan S, Chen G, Yin Y, Zhang Y, Wu X. Electroacupuncture ameliorates gastrointestinal dysfunction by modulating DMV cholinergic efferent signals to drive the vagus nerve in p-MCAO rats. Heliyon. 2024 Apr 9;10(8):e29426. doi: 10.1016/j.heliyon.2024.e29426. PMID: 38638995; PMCID: PMC11024612. 6: Tian J, Mu Y, Ma L. Chemerin/CMKLR1 pathway exacerbates cisplatin-induced spiral ganglion neuron injury. Toxicol Res. 2023 Aug 24;40(1):73-81. doi: 10.1007/s43188-023-00205-0. PMID: 38223664; PMCID: PMC10786799. 7: Nejabati HR, Nikzad S, Roshangar L. Alleviative Effects of Adipose Tissue- derived Stem Cells and α-NETA on Metabolic, Biochemical, and Endocrine Parameters in a Letrozole-induced Rat Model of PCOS. Curr Pharm Des. 2023;29(24):1929-1938. doi: 10.2174/1381612829666230816100641. PMID: 37584355. 8: Peng Z, Wang X, Zhu Q, Wang H, Li B, Pang X, Han J. CMKLR1 Antagonist Alpha- NETA Protects against Diabetic Nephropathy in Mice. Kidney Blood Press Res. 2023;48(1):405-413. doi: 10.1159/000530763. Epub 2023 May 10. PMID: 37231814; PMCID: PMC10308536. 9: Zheng C, Zheng Y, Chen X, Zhong X, Zheng X, Yang S, Zheng Z. α-NETA down- regulates CMKLR1 mRNA expression in ileum and prevents body weight gains collaborating with ERK inhibitor PD98059 in turn to alleviate hepatic steatosis in HFD-induced obese mice but no impact on ileal mucosal integrity and steatohepatitis progression. BMC Endocr Disord. 2023 Jan 10;23(1):9. doi: 10.1186/s12902-023-01267-9. PMID: 36624417; PMCID: PMC9830776. 10: Sanges S, Rice L, Tu L, Valenzi E, Cracowski JL, Montani D, Mantero JC, Ternynck C, Marot G, Bujor AM, Hachulla E, Launay D, Humbert M, Guignabert C, Lafyatis R. Biomarkers of haemodynamic severity of systemic sclerosis-associated pulmonary arterial hypertension by serum proteome analysis. Ann Rheum Dis. 2023 Mar;82(3):365-373. doi: 10.1136/ard-2022-223237. Epub 2022 Dec 5. PMID: 36600187; PMCID: PMC9918672. 11: Yu M, Yang Y, Zhao H, Li M, Chen J, Wang B, Xiao T, Huang C, Zhao H, Zhou W, Zhang JV. Targeting the chemerin/CMKLR1 axis by small molecule antagonist α-NETA mitigates endometriosis progression. Front Pharmacol. 2022 Nov 29;13:985618. doi: 10.3389/fphar.2022.985618. PMID: 36523492; PMCID: PMC9745129. 12: Wang JX, Wang XL, Xu ZQ, Zhang Y, Xue D, Zhu R, Chen Q, Li YH, Zhu GQ, Tan X. Chemerin-9 in paraventricular nucleus increases sympathetic outflow and blood pressure via glutamate receptor-mediated ROS generation. Eur J Pharmacol. 2022 Dec 5;936:175343. doi: 10.1016/j.ejphar.2022.175343. Epub 2022 Oct 25. PMID: 36306926. 13: Peng X, Wang W, Wang W, Qi J. Alpha-NETA, as a CMKLR1 Small Molecule Antagonist, Protects against Renal Ischemia Reperfusion Injury in Mice. Protein Pept Lett. 2022;29(11):962-970. doi: 10.2174/0929866529666220822095950. PMID: 35996267. 14: Yun H, Dumbell R, Hanna K, Bowen J, McLean SL, Kantamneni S, Pors K, Wu QF, Helfer G. The Chemerin-CMKLR1 Axis is Functionally important for Central Regulation of Energy Homeostasis. Front Physiol. 2022 May 30;13:897105. doi: 10.3389/fphys.2022.897105. PMID: 35711300; PMCID: PMC9196942. 15: Zhang Q, Xiao Z, Lee CL, Duan YG, Fan X, Yeung WSB, Chiu PCN, Zhang JV. The Regulatory Roles of Chemerin-Chemokine-Like Receptor 1 Axis in Placental Development and Vascular Remodeling During Early Pregnancy. Front Cell Dev Biol. 2022 May 17;10:883636. doi: 10.3389/fcell.2022.883636. PMID: 35656551; PMCID: PMC9152263. 16: Tan L, Chen Z, Sun F, Zhou Z, Zhang B, Wang B, Chen J, Li M, Xiao T, Neuman RI, Niu J, Verdonk K, Lu X, Zhang JV, Danser AHJ, Yang Q, Fan X. Placental trophoblast-specific overexpression of chemerin induces preeclampsia-like symptoms. Clin Sci (Lond). 2022 Feb 25;136(4):257-272. doi: 10.1042/CS20210989. PMID: 35103285; PMCID: PMC8844909. 17: Ji ZS, Jiang H, Xie Y, Wei QP, Yin XF, Ye JH, Quan XZ, Lan YL, Zhao M, Tian XL, Zhang YJ, Yang XZ. Chemerin promotes the pathogenesis of preeclampsia by activating CMKLR1/p-Akt/CEBPɑ axis and inducing M1 macrophage polarization. Cell Biol Toxicol. 2022 Aug;38(4):611-628. doi: 10.1007/s10565-021-09636-7. Epub 2021 Aug 16. PMID: 34398343. 18: An X, Liu J, Li Y, Dou Z, Li N, Suo Y, Ma Y, Sun M, Tian Z, Xu L. Chemerin/CMKLR1 ameliorates nonalcoholic steatohepatitis by promoting autophagy and alleviating oxidative stress through the JAK2-STAT3 pathway. Peptides. 2021 Jan;135:170422. doi: 10.1016/j.peptides.2020.170422. Epub 2020 Nov 2. PMID: 33144092. 19: Aleksandrov AA, Knyazeva VM, Volnova AB, Dmitrieva ES, Polyakova NV. Putative TAAR5 agonist alpha-NETA affects event-related potentials in oddball paradigm in awake mice. Brain Res Bull. 2020 May;158:116-121. doi: 10.1016/j.brainresbull.2020.03.005. Epub 2020 Mar 6. PMID: 32151716. 20: Huang B, Zhao H, Huang C, Wu L, Xiang L, Chen J, Wang B, Xiao T, Li M, Ren L, Niu J, Zhang JV. CMKLR1 deficiency attenuates androgen-induced lipid accumulation in mice. Am J Physiol Endocrinol Metab. 2020 Mar 1;318(3):E371-E380. doi: 10.1152/ajpendo.00176.2019. Epub 2020 Jan 7. PMID: 31910029.