MedKoo Cat#: 562657 | Name: Dansyl-NECA

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Dansyl-NECA is a selective fluorescent adenosine A1 receptor agonist.

Chemical Structure

Dansyl-NECA
Dansyl-NECA
CAS#219982-12-4

Theoretical Analysis

MedKoo Cat#: 562657

Name: Dansyl-NECA

CAS#: 219982-12-4

Chemical Formula: C30H40N8O6S

Exact Mass: 640.2792

Molecular Weight: 640.76

Elemental Analysis: C, 56.23; H, 6.29; N, 17.49; O, 14.98; S, 5.00

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
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Related CAS #
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Synonym
Dansyl-NECA; DansylNECA; Dansyl NECA;
IUPAC/Chemical Name
(2S,3S,4R,5R)-5-(6-((6-((5-(dimethylamino)naphthalene)-1-sulfonamido)hexyl)amino)-9H-purin-9-yl)-N-ethyl-3,4-dihydroxytetrahydrofuran-2-carboxamide
InChi Key
CJDPJPUVKHWZHU-YRIIQKNPSA-N
InChi Code
InChI=1S/C30H40N8O6S/c1-4-31-29(41)26-24(39)25(40)30(44-26)38-18-35-23-27(33-17-34-28(23)38)32-15-7-5-6-8-16-36-45(42,43)22-14-10-11-19-20(22)12-9-13-21(19)37(2)3/h9-14,17-18,24-26,30,36,39-40H,4-8,15-16H2,1-3H3,(H,31,41)(H,32,33,34)/t24-,25+,26-,30+/m0/s1
SMILES Code
CN(C1=CC=CC2=C1C=CC=C2S(NCCCCCCNC3=NC=NC4=C3N=CN4[C@@H]5O[C@H](C(NCC)=O)[C@@H](O)[C@H]5O)(=O)=O)C
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>2 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 640.76 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Baker JG, Middleton R, Adams L, May LT, Briddon SJ, Kellam B, Hill SJ. Influence of fluorophore and linker composition on the pharmacology of fluorescent adenosine A1 receptor ligands. Br J Pharmacol. 2010 Feb;159(4):772-86. doi: 10.1111/j.1476-5381.2009.00488.x. Epub 2010 Jan 26. PubMed PMID: 20105183; PubMed Central PMCID: PMC2829203. 2: Macchia M, Salvetti F, Barontini S, Calvani F, Gesi M, Hamdan M, Lucacchini A, Pellegrini A, Soldani P, Martini C. Fluorescent probes for adenosine receptors: synthesis and biology of N6-dansylaminoalkyl-substituted NECA derivatives. Bioorg Med Chem Lett. 1998 Nov 17;8(22):3223-8. PubMed PMID: 9873707.